CRCGN013_HEPG2_24H:H04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methacrylonitrile 5.22 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

34 genes differentially expressed following the CRCGN013_HEPG2_24H:H04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 5.09611
STIMATE STIM activating enhancer 4.74985
EPN2 epsin 2 3.85955
LCN2 lipocalin 2 3.75606
CHMP6 charged multivesicular body protein 6 3.71951
MYLK myosin light chain kinase 3.70659
RAB11FIP1 RAB11 family interacting protein 1 (class I) 3.4717
STXBP2 syntaxin binding protein 2 3.26524
RXYLT1 ribitol xylosyltransferase 1 3.11349
LSR lipolysis stimulated lipoprotein receptor 2.86776
GRWD1 glutamate-rich WD repeat containing 1 2.48375
JADE2 jade family PHD finger 2 2.35461
CYCS cytochrome c, somatic 2.21234
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.13667
KLHL21 kelch-like family member 21 2.07936
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.05479

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -5.09216
UGDH UDP-glucose 6-dehydrogenase -4.28516
EGF epidermal growth factor -3.82851
MAP7 microtubule-associated protein 7 -3.60657
NRIP1 nuclear receptor interacting protein 1 -3.48736
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.46556
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.10706
EIF5 eukaryotic translation initiation factor 5 -2.88655
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.77836
GNAS GNAS complex locus -2.61777
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.55653
HLA-DMA major histocompatibility complex, class II, DM alpha -2.31539
OXA1L oxidase (cytochrome c) assembly 1-like -2.29108
BMPR1B bone morphogenetic protein receptor, type IB -2.2353
TLCD3A TLC domain containing 3A -2.22082
GET1 guided entry of tail-anchored proteins factor 1 -2.19377
IFRD2 interferon-related developmental regulator 2 -2.15704
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.09963