CRCGN013_HEPG2_24H:H05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methacrylonitrile 2.61 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

35 genes differentially expressed following the CRCGN013_HEPG2_24H:H05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.11817
TBP TATA box binding protein 3.02968
PRR15L proline rich 15-like 2.99813
JADE2 jade family PHD finger 2 2.89876
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.87066
ANO1 anoctamin 1, calcium activated chloride channel 2.85487
HOXA10 homeobox A10 2.82681
E2F2 E2F transcription factor 2 2.71018
NOTCH1 notch 1 2.61677
HSPA1A heat shock 70kDa protein 1A 2.54792
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.45281
PDLIM1 PDZ and LIM domain 1 2.26287
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.22298
TBXA2R thromboxane A2 receptor 2.21209
LCN2 lipocalin 2 2.10447
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.08946
C2CD2 C2 calcium-dependent domain containing 2 2.08403

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -9.38879
PCNA proliferating cell nuclear antigen -6.54708
C2CD5 C2 calcium-dependent domain containing 5 -4.34776
ZNF586 zinc finger protein 586 -4.22282
ZMIZ1 zinc finger, MIZ-type containing 1 -4.1934
FGFR4 fibroblast growth factor receptor 4 -4.1227
CCNB1 cyclin B1 -3.95496
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -3.66589
OXA1L oxidase (cytochrome c) assembly 1-like -3.25141
DSG2 desmoglein 2 -3.21743
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.1237
FASTKD5 FAST kinase domains 5 -3.11284
MAPK13 mitogen-activated protein kinase 13 -2.86628
CDC20 cell division cycle 20 -2.85487
BCL2L10 BCL2-like 10 (apoptosis facilitator) -2.75326
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.7518
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.32649
FBXO7 F-box protein 7 -2.0871