CRCGN013_HEPG2_24H:H07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-[2,2-dichloro-1-(4-ethylphenyl)ethyl]-4-ethylbenzene 40.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

105 genes differentially expressed following the CRCGN013_HEPG2_24H:H07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CTSL cathepsin L 5.12696
ADGRE5 adhesion G protein-coupled receptor E5 4.45825
TIMP2 TIMP metallopeptidase inhibitor 2 3.95175
GSTZ1 glutathione S-transferase zeta 1 3.86368
LCN2 lipocalin 2 3.80126
SKIC2 SKI2 subunit of superkiller complex 3.75103
MVP major vault protein 3.73587
UBQLN2 ubiquilin 2 3.629
ABHD6 abhydrolase domain containing 6 3.54196
PHKG2 phosphorylase kinase, gamma 2 (testis) 3.50413
CCNA1 cyclin A1 3.4375
CNPY3 canopy FGF signaling regulator 3 3.32634
RPL39L ribosomal protein L39-like 3.29325
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.25375
GATA3 GATA binding protein 3 3.11697
VAT1 vesicle amine transport 1 3.08266
MICALL1 MICAL-like 1 3.02879
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.9631
CD40 CD40 molecule, TNF receptor superfamily member 5 2.96171
CCNF cyclin F 2.89905
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 2.82299
HLA-DRA major histocompatibility complex, class II, DR alpha 2.79089
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.70876
TRIB3 tribbles pseudokinase 3 2.6686
INPP1 inositol polyphosphate-1-phosphatase 2.63758
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.62835
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.58996
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.55619
BACE2 beta-site APP-cleaving enzyme 2 2.34943
GRB10 growth factor receptor-bound protein 10 2.31219
PPARG peroxisome proliferator-activated receptor gamma 2.30525
CCNH cyclin H 2.28198
SQSTM1 sequestosome 1 2.25369
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.24726
CEP57 centrosomal protein 57kDa 2.22824
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.21347
CDC45 cell division cycle 45 2.20678
MYLK myosin light chain kinase 2.20179
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.20162
NANOS3 nanos homolog 3 (Drosophila) 2.18666
CHMP6 charged multivesicular body protein 6 2.17821
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 2.15807
GLRX glutaredoxin (thioltransferase) 2.14151
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 2.13712
FCHO1 FCH domain only 1 2.13187
CXCL9 chemokine (C-X-C motif) ligand 9 2.1277
TRIB1 tribbles pseudokinase 1 2.0607
CCDC198 coiled-coil domain containing 198 2.03437
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.02252
TLR4 toll-like receptor 4 2.02104

decreased expression

Symbol Name Standardized Value
ISOC1 isochorismatase domain containing 1 -5.32174
NUP85 nucleoporin 85kDa -4.50391
TCTN1 tectonic family member 1 -4.12169
THAP11 THAP domain containing 11 -4.05664
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.7128
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.68336
CASP3 caspase 3, apoptosis-related cysteine peptidase -3.422
CD320 CD320 molecule -3.33805
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.23106
MRPS7 mitochondrial ribosomal protein S7 -3.1643
DNM1L dynamin 1-like -3.11587
LDHD lactate dehydrogenase D -3.06674
MELK maternal embryonic leucine zipper kinase -3.0661
DERA deoxyribose-phosphate aldolase (putative) -3.02954
RGS2 regulator of G-protein signaling 2 -3.00376
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.95587
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide -2.93356
TLCD3A TLC domain containing 3A -2.93343
GDF15 growth differentiation factor 15 -2.76094
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.74868
CHEK1 checkpoint kinase 1 -2.72544
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.72084
LOC124907782 dual specificity protein phosphatase 22 -2.70799
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide -2.69814
FBXL12 F-box and leucine-rich repeat protein 12 -2.65512
NGRN neugrin, neurite outgrowth associated -2.62826
COG2 component of oligomeric golgi complex 2 -2.60673
ZMIZ1 zinc finger, MIZ-type containing 1 -2.58845
CCNA2 cyclin A2 -2.55448
MRPL58 mitochondrial ribosomal protein L58 -2.53649
GNAS GNAS complex locus -2.47854
KCTD2 potassium channel tetramerization domain containing 2 -2.47165
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit -2.43148
LBR lamin B receptor -2.42216
PLK1 polo-like kinase 1 -2.38812
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.38302
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.37711
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.32645
FAIM Fas apoptotic inhibitory molecule -2.31725
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.25277
ZNF274 zinc finger protein 274 -2.24935
TCERG1 transcription elongation regulator 1 -2.226
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.21674
CRELD2 cysteine-rich with EGF-like domains 2 -2.20627
STMN1 stathmin 1 -2.20579
DDB2 damage-specific DNA binding protein 2, 48kDa -2.20147
COPS7A COP9 signalosome subunit 7A -2.19663
AURKB aurora kinase B -2.18432
GTF2A2 general transcription factor IIA, 2, 12kDa -2.17022
HEATR1 HEAT repeat containing 1 -2.13523
PMP2 peripheral myelin protein 2 -2.11839
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 -2.10615
CCNB1 cyclin B1 -2.09849
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.0318
CDK1 cyclin-dependent kinase 1 -2.01248