CRCGN013_HEPG2_24H:H08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-[2,2-dichloro-1-(4-ethylphenyl)ethyl]-4-ethylbenzene 20.3 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

62 genes differentially expressed following the CRCGN013_HEPG2_24H:H08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STK10 serine/threonine kinase 10 7.22875
AMDHD2 amidohydrolase domain containing 2 6.36674
PPP1R13B protein phosphatase 1, regulatory subunit 13B 6.06907
LCN2 lipocalin 2 6.06779
ABHD6 abhydrolase domain containing 6 5.77716
PPARG peroxisome proliferator-activated receptor gamma 4.56504
PIH1D1 PIH1 domain containing 1 4.46837
UBQLN2 ubiquilin 2 4.38624
IL1B interleukin 1, beta 4.25042
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.03394
SNAP25 synaptosomal-associated protein, 25kDa 3.99011
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.94668
E2F2 E2F transcription factor 2 3.64009
CISD1 CDGSH iron sulfur domain 1 3.61259
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.42981
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.28745
RRAGA Ras-related GTP binding A 3.23766
ADAT1 adenosine deaminase, tRNA-specific 1 3.12998
SSBP2 single-stranded DNA binding protein 2 3.11054
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.08754
NOSIP nitric oxide synthase interacting protein 3.07728
CNPY3 canopy FGF signaling regulator 3 3.05
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.03745
EVL Enah/Vasp-like 2.97915
SOCS2 suppressor of cytokine signaling 2 2.93748
CHN1 chimerin 1 2.79793
FGF14 fibroblast growth factor 14 2.69724
FCHO1 FCH domain only 1 2.40791
CEMIP2 cell migration inducing hyaluronidase 2 2.39221
CIAO3 cytosolic iron-sulfur assembly component 3 2.36719
JADE2 jade family PHD finger 2 2.34098
LSR lipolysis stimulated lipoprotein receptor 2.26826
CCNH cyclin H 2.23351
EGF epidermal growth factor 2.2027
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.1883
SFTPB surfactant protein B 2.13707
RAB7A RAB7A, member RAS oncogene family 2.0234

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.14727
OXA1L oxidase (cytochrome c) assembly 1-like -5.35938
RGS2 regulator of G-protein signaling 2 -4.47135
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.93775
ZNF586 zinc finger protein 586 -3.70861
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.48994
C2CD5 C2 calcium-dependent domain containing 5 -3.43246
VDAC1 voltage-dependent anion channel 1 -3.40169
TNIP1 TNFAIP3 interacting protein 1 -3.02082
LOC124907782 dual specificity protein phosphatase 22 -2.86599
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.6238
TLCD3A TLC domain containing 3A -2.55174
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.50175
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.48595
MDN1 MDN1, midasin homolog (yeast) -2.38031
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.24913
TCTN1 tectonic family member 1 -2.21938
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.2131
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.20821
POU5F1 POU class 5 homeobox 1 -2.11309
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.10984
KAT7 K(lysine) acetyltransferase 7 -2.08983
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.04201
ETFB electron-transfer-flavoprotein, beta polypeptide -2.03085
RCOR3 REST corepressor 3 -2.0175