CRCGN013_HEPG2_24H:H09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-[2,2-dichloro-1-(4-ethylphenyl)ethyl]-4-ethylbenzene 10.15 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN013_HEPG2_24H:H09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 4.10196
CEP57 centrosomal protein 57kDa 3.67961
NOTCH1 notch 1 3.64505
RAB11FIP1 RAB11 family interacting protein 1 (class I) 3.46482
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.35754
STK10 serine/threonine kinase 10 3.3236
GSTZ1 glutathione S-transferase zeta 1 3.15147
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.66862
TBPL1 TBP-like 1 2.61067
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.60675
PRR15L proline rich 15-like 2.52619
LRP10 low density lipoprotein receptor-related protein 10 2.43913
PPARG peroxisome proliferator-activated receptor gamma 2.35645
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.01605

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -7.38635
CCNB2 cyclin B2 -6.23661
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.35144
SLC35F2 solute carrier family 35, member F2 -4.18007
TLCD3A TLC domain containing 3A -3.84236
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.68993
PCNA proliferating cell nuclear antigen -3.49795
CDC20 cell division cycle 20 -3.35411
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.31187
CASP3 caspase 3, apoptosis-related cysteine peptidase -3.30505
HEATR1 HEAT repeat containing 1 -3.13582
OXA1L oxidase (cytochrome c) assembly 1-like -3.05212
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.96959
EIF5 eukaryotic translation initiation factor 5 -2.76148
GNAS GNAS complex locus -2.67288
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.63492
CCP110 centriolar coiled coil protein 110kDa -2.29021
DCK deoxycytidine kinase -2.14261
EXT1 exostosin glycosyltransferase 1 -2.02966