CRCGN013_HEPG2_24H:H11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-[2,2-dichloro-1-(4-ethylphenyl)ethyl]-4-ethylbenzene 2.54 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

24 genes differentially expressed following the CRCGN013_HEPG2_24H:H11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NOTCH1 notch 1 4.46385
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.37607
PNKP polynucleotide kinase 3'-phosphatase 4.23579
LCN2 lipocalin 2 4.1444
NOSIP nitric oxide synthase interacting protein 4.01984
HLA-DRA major histocompatibility complex, class II, DR alpha 3.47595
MAP7 microtubule-associated protein 7 3.36001
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.30648
VGLL4 vestigial-like family member 4 2.85142

decreased expression

Symbol Name Standardized Value
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.61214
MAPK13 mitogen-activated protein kinase 13 -4.48027
CDC20 cell division cycle 20 -4.1444
CCNB2 cyclin B2 -3.76591
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.71168
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.62964
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.26192
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.88015
EGF epidermal growth factor -2.50219
UBE3C ubiquitin protein ligase E3C -2.44428
SOAT2 sterol O-acyltransferase 2 -2.34944
SNX11 sorting nexin 11 -2.31418
GRN granulin -2.24627
CD80 CD80 molecule -2.13044
SLAMF1 signaling lymphocytic activation molecule family member 1 -2.08053