CRCGN013_HEPG2_24H:H12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-[2,2-dichloro-1-(4-ethylphenyl)ethyl]-4-ethylbenzene 1.27 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN013_HEPG2_24H:H12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ALDOC aldolase C, fructose-bisphosphate 4.47045
E2F2 E2F transcription factor 2 4.39743
HLA-DMA major histocompatibility complex, class II, DM alpha 4.3452
CIAO3 cytosolic iron-sulfur assembly component 3 4.18873
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.09028
INTS3 integrator complex subunit 3 4.04567
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.99644
CCL2 chemokine (C-C motif) ligand 2 3.94305
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.90811
STK10 serine/threonine kinase 10 3.90771
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.90569
FZD7 frizzled class receptor 7 3.61819
EVL Enah/Vasp-like 3.34199
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.13995
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.90506
DYNLT3 dynein, light chain, Tctex-type 3 2.80297
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.64466
MAP7 microtubule-associated protein 7 2.45476
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.33526
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 2.20369
ABHD10 abhydrolase domain containing 10 2.17369
GPATCH8 G patch domain containing 8 2.14521
CHN1 chimerin 1 2.13013
HOXB7 homeobox B7 2.10865
DKK4 dickkopf WNT signaling pathway inhibitor 4 2.09927
HLA-DRA major histocompatibility complex, class II, DR alpha 2.04111

decreased expression

Symbol Name Standardized Value
DNM1L dynamin 1-like -4.29027
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.24815
VDAC1 voltage-dependent anion channel 1 -4.05903
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.9068
PCNA proliferating cell nuclear antigen -3.88038
COG2 component of oligomeric golgi complex 2 -3.80147
MAPK13 mitogen-activated protein kinase 13 -3.43875
EIF5 eukaryotic translation initiation factor 5 -2.73643
GNAS GNAS complex locus -2.71599
TLCD3A TLC domain containing 3A -2.46805
TOR1A torsin family 1, member A (torsin A) -2.41026
CD58 CD58 molecule -2.25484
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.20872
VAT1 vesicle amine transport 1 -2.14501
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.09088
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.08596