CRCGN013_HEPG2_24H:H13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nifedipine 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN013_HEPG2_24H:H13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 3.4324
SQOR sulfide quinone oxidoreductase 3.35396
PPARG peroxisome proliferator-activated receptor gamma 3.26497
CBR3 carbonyl reductase 3 2.89319
WASF3 WAS protein family, member 3 2.81761
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.79424
USP6NL USP6 N-terminal like 2.77668
ABHD6 abhydrolase domain containing 6 2.74228
STK10 serine/threonine kinase 10 2.73931
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.7278
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.67117
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.5702
STXBP1 syntaxin binding protein 1 2.4463
UBQLN2 ubiquilin 2 2.39886
HLA-DRA major histocompatibility complex, class II, DR alpha 2.35432
E2F2 E2F transcription factor 2 2.26744
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) 2.25736
LOC122526780 uncharacterized LOC122526780 2.22563
NOSIP nitric oxide synthase interacting protein 2.10879
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.02294

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -4.32724
LDHD lactate dehydrogenase D -3.56955
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.19353
MRPS2 mitochondrial ribosomal protein S2 -3.08408
FASTKD5 FAST kinase domains 5 -3.03009
EGF epidermal growth factor -2.7991
CDC20 cell division cycle 20 -2.70854
NRIP1 nuclear receptor interacting protein 1 -2.6546
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.57983
YME1L1 YME1-like 1 ATPase -2.54923
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.4872
RAI14 retinoic acid induced 14 -2.46836
FGFR4 fibroblast growth factor receptor 4 -2.39934
NGRN neugrin, neurite outgrowth associated -2.27538
FBXO7 F-box protein 7 -2.2507
CCNB2 cyclin B2 -2.2068
LY75-CD302 LY75-CD302 readthrough -2.15467
EIF5 eukaryotic translation initiation factor 5 -2.11757
ACLY ATP citrate lyase -2.08931
KDM3A lysine (K)-specific demethylase 3A -2.08418