CRCGN013_HEPG2_24H:H14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nifedipine 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN013_HEPG2_24H:H14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
BAMBI BMP and activin membrane-bound inhibitor 5.19712
CBR3 carbonyl reductase 3 4.77958
CEP57 centrosomal protein 57kDa 3.55414
PRR15L proline rich 15-like 3.55089
HLA-DRA major histocompatibility complex, class II, DR alpha 3.51462
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.34721
AMDHD2 amidohydrolase domain containing 2 2.86388
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.80509
TAC4 tachykinin 4 (hemokinin) 2.7826
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.71345
CAPN1 calpain 1, (mu/I) large subunit 2.68098
RFC5 replication factor C (activator 1) 5, 36.5kDa 2.47711
SKIC2 SKI2 subunit of superkiller complex 2.47554
SOCS2 suppressor of cytokine signaling 2 2.34634
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.31583
KIF20A kinesin family member 20A 2.30762
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.25507
ADAT1 adenosine deaminase, tRNA-specific 1 2.19723
MAP7 microtubule-associated protein 7 2.13665

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -5.20668
CDC25B cell division cycle 25B -5.00728
TLCD3A TLC domain containing 3A -3.984
KDM3A lysine (K)-specific demethylase 3A -3.59405
ZW10 zw10 kinetochore protein -3.46471
CD320 CD320 molecule -3.35021
EGF epidermal growth factor -3.20929
NUP85 nucleoporin 85kDa -3.07677
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.89239
SLC35F2 solute carrier family 35, member F2 -2.84728
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.77158
TXNDC9 thioredoxin domain containing 9 -2.62613
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.46994
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.4121
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.30347
TCF12 transcription factor 12 -2.29106
DERA deoxyribose-phosphate aldolase (putative) -2.26176
GNAS GNAS complex locus -2.15201
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.14921
MVP major vault protein -2.13831
GRB2 growth factor receptor-bound protein 2 -2.10751
WASHC4 WASH complex subunit 4 -2.09742
MAPK13 mitogen-activated protein kinase 13 -2.09151