CRCGN013_HEPG2_24H:H17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nifedipine 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN013_HEPG2_24H:H17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CARMIL1 capping protein regulator and myosin 1 linker 1 7.62379
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 5.66326
CHN1 chimerin 1 5.55316
RPP38 ribonuclease P/MRP 38kDa subunit 4.46845
LCN2 lipocalin 2 4.15905
UBQLN2 ubiquilin 2 3.83684
CBR1 carbonyl reductase 1 3.73656
BZW2 basic leucine zipper and W2 domains 2 3.21076
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.06869
DYNLT3 dynein, light chain, Tctex-type 3 2.89492
NOTCH1 notch 1 2.8403
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.70608
STIMATE STIM activating enhancer 2.70487
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.47718
ADAT1 adenosine deaminase, tRNA-specific 1 2.41105
EPHA3 EPH receptor A3 2.25418
MRPS16 mitochondrial ribosomal protein S16 2.165
SH3D19 SH3 domain containing 19 2.11349
RRAGA Ras-related GTP binding A 2.10244
SOCS2 suppressor of cytokine signaling 2 2.02371
PIH1D1 PIH1 domain containing 1 2.01455
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.00903

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -5.97017
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.92094
HMG20B high mobility group 20B -4.33539
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.09683
DERA deoxyribose-phosphate aldolase (putative) -3.43166
RAI14 retinoic acid induced 14 -2.85954
DCK deoxycytidine kinase -2.80997
TENT4A terminal nucleotidyltransferase 4A -2.78485
ITGB1BP1 integrin beta 1 binding protein 1 -2.55651
TXNDC9 thioredoxin domain containing 9 -2.45927
TLR4 toll-like receptor 4 -2.3757
MTA1 metastasis associated 1 -2.36756
SESN1 sestrin 1 -2.34049
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.28516
TMEM109 transmembrane protein 109 -2.20975
PCNA proliferating cell nuclear antigen -2.19087
CCNB2 cyclin B2 -2.13476
DRD4 dopamine receptor D4 -2.07244