CRCGN013_HEPG2_24H:H18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nifedipine 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

70 genes differentially expressed following the CRCGN013_HEPG2_24H:H18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 5.63056
LAGE3 L antigen family, member 3 5.2862
CBR3 carbonyl reductase 3 5.26883
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.09932
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.06794
BACE2 beta-site APP-cleaving enzyme 2 4.57922
CCL2 chemokine (C-C motif) ligand 2 3.83653
IDE insulin-degrading enzyme 3.82332
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.73537
GATA3 GATA binding protein 3 3.68821
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.59448
TIAM1 T-cell lymphoma invasion and metastasis 1 3.51717
PRKCH protein kinase C, eta 3.42016
MAMLD1 mastermind-like domain containing 1 3.20837
PLSCR1 phospholipid scramblase 1 3.03409
SV2A synaptic vesicle glycoprotein 2A 2.98586
CDPF1 cysteine-rich, DPF motif domain containing 1 2.97132
RPL39L ribosomal protein L39-like 2.86855
IGHMBP2 immunoglobulin mu binding protein 2 2.85122
CYCS cytochrome c, somatic 2.73908
GLB1 galactosidase, beta 1 2.72083
STXBP2 syntaxin binding protein 2 2.66104
LYN LYN proto-oncogene, Src family tyrosine kinase 2.64219
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.59573
CHN1 chimerin 1 2.50503
MELK maternal embryonic leucine zipper kinase 2.47969
CRTAP cartilage associated protein 2.45136
ADAT1 adenosine deaminase, tRNA-specific 1 2.41196
TESC tescalcin 2.3926
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.27177
GCH1 GTP cyclohydrolase 1 2.2192
MAN2B2 mannosidase, alpha, class 2B, member 2 2.21564
GRWD1 glutamate-rich WD repeat containing 1 2.17699
HYOU1 hypoxia up-regulated 1 2.17292
LPAR2 lysophosphatidic acid receptor 2 2.13863
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.09379
TBC1D10C TBC1 domain family, member 10C 2.08542
ASL argininosuccinate lyase 2.05189
CCDC6 coiled-coil domain containing 6 2.04533
LOC124900388 uncharacterized LOC124900388 2.04022
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 2.0196
LYRM1 LYR motif containing 1 2.00852

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -8.74719
ZNF586 zinc finger protein 586 -7.1514
TSPAN4 tetraspanin 4 -6.21749
TUBB6 tubulin, beta 6 class V -5.37259
SLC35F2 solute carrier family 35, member F2 -4.29466
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.72368
ZDHHC6 zinc finger, DHHC-type containing 6 -3.53326
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.50027
TCTN1 tectonic family member 1 -3.45166
CDC20 cell division cycle 20 -3.38616
NVL nuclear VCP-like -2.9486
KDM3A lysine (K)-specific demethylase 3A -2.92945
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.91337
LDHD lactate dehydrogenase D -2.8996
EGF epidermal growth factor -2.84091
CAB39 calcium binding protein 39 -2.83374
MRPS16 mitochondrial ribosomal protein S16 -2.6606
ZNF134 zinc finger protein 134 -2.49641
OXA1L oxidase (cytochrome c) assembly 1-like -2.47883
NRIP1 nuclear receptor interacting protein 1 -2.29254
EPHX2 epoxide hydrolase 2, cytoplasmic -2.2475
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.09362
RIC8B RIC8 guanine nucleotide exchange factor B -2.05541
SPAG4 sperm associated antigen 4 -2.05485
FRS2 fibroblast growth factor receptor substrate 2 -2.03554
ZNF304 zinc finger protein 304 -2.00605
ABHD10 abhydrolase domain containing 10 -2.00326
COMMD3 COMM domain containing 3 -2.00066