CRCGN013_HEPG2_24H:H19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pyrimethamine 40.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

213 genes differentially expressed following the CRCGN013_HEPG2_24H:H19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 9.06401
LCN2 lipocalin 2 8.69063
KIFBP kinesin family binding protein 7.23777
TIMP2 TIMP metallopeptidase inhibitor 2 6.24455
CNPY3 canopy FGF signaling regulator 3 6.10773
EDN1 endothelin 1 5.78873
S100A4 S100 calcium binding protein A4 5.3455
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 4.90436
NPC1 Niemann-Pick disease, type C1 4.57395
INPP1 inositol polyphosphate-1-phosphatase 4.26711
GPATCH8 G patch domain containing 8 4.26028
GLRX glutaredoxin (thioltransferase) 4.14072
IER3 immediate early response 3 4.13748
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.7545
LGALS8 lectin, galactoside-binding, soluble, 8 3.71926
ADGRE5 adhesion G protein-coupled receptor E5 3.71724
BACE2 beta-site APP-cleaving enzyme 2 3.7145
IGFBP3 insulin-like growth factor binding protein 3 3.70861
NPDC1 neural proliferation, differentiation and control, 1 3.53549
SNX7 sorting nexin 7 3.47734
ACOT9 acyl-CoA thioesterase 9 3.43659
GOLT1B golgi transport 1B 3.34781
MYLK myosin light chain kinase 3.34633
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 3.23606
CIAO3 cytosolic iron-sulfur assembly component 3 3.19639
TUBB6 tubulin, beta 6 class V 3.19188
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.14702
SQOR sulfide quinone oxidoreductase 3.12388
VAT1 vesicle amine transport 1 3.09823
MVP major vault protein 3.0958
MEF2C myocyte enhancer factor 2C 3.04807
HLA-DRA major histocompatibility complex, class II, DR alpha 3.04752
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.0475
ITGB5 integrin, beta 5 3.03511
DYNLT3 dynein, light chain, Tctex-type 3 2.96742
TRIB1 tribbles pseudokinase 1 2.95107
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.94661
FHL2 four and a half LIM domains 2 2.90001
TWF2 twinfilin actin binding protein 2 2.88695
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.84921
DDB2 damage-specific DNA binding protein 2, 48kDa 2.84115
CDC45 cell division cycle 45 2.83004
LRP10 low density lipoprotein receptor-related protein 10 2.81851
CD40 CD40 molecule, TNF receptor superfamily member 5 2.60136
AMDHD2 amidohydrolase domain containing 2 2.5985
TPD52L2 tumor protein D52-like 2 2.55526
LSR lipolysis stimulated lipoprotein receptor 2.55212
KLHL21 kelch-like family member 21 2.53781
DUSP6 dual specificity phosphatase 6 2.51991
MICALL1 MICAL-like 1 2.51115
ERCC5 excision repair cross-complementation group 5 2.49334
HSPA1A heat shock 70kDa protein 1A 2.46691
AUP1 ancient ubiquitous protein 1 2.45199
PNKP polynucleotide kinase 3'-phosphatase 2.44876
BECN1 beclin 1, autophagy related 2.41442
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.41282
CYTH1 cytohesin 1 2.30708
P3H3 prolyl 3-hydroxylase 3 2.30459
MOK MOK protein kinase 2.28108
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 2.25843
TICAM1 toll-like receptor adaptor molecule 1 2.25294
VPS33B vacuolar protein sorting 33 homolog B (yeast) 2.24568
DIPK1A divergent protein kinase domain 1A 2.23712
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.22415
CD2AP CD2-associated protein 2.20908
UCKL1 uridine-cytidine kinase 1-like 1 2.20778
PROCR protein C receptor, endothelial 2.20661
UBQLN2 ubiquilin 2 2.19621
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.18502
HTRA1 HtrA serine peptidase 1 2.18044
TUBG2 tubulin, gamma 2 2.15146
LARP6 La ribonucleoprotein domain family, member 6 2.14343
YPEL5 yippee-like 5 (Drosophila) 2.13991
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.13944
YJU2B YJU2 splicing factor homolog B 2.13066
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 2.11562
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 2.08847
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.06595
ANTKMT adenine nucleotide translocase lysine methyltransferase 2.05326
NFE2L1 nuclear factor, erythroid 2-like 1 2.05188
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 2.043
HLA-DMA major histocompatibility complex, class II, DM alpha 2.03914
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 2.03284
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 2.02575
ANO10 anoctamin 10 2.02237
BAMBI BMP and activin membrane-bound inhibitor 2.01025
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 2.00714

decreased expression

Symbol Name Standardized Value
NT5DC2 5'-nucleotidase domain containing 2 -9.38593
CDC20 cell division cycle 20 -7.04813
ANKRD10 ankyrin repeat domain 10 -6.17939
ISOC1 isochorismatase domain containing 1 -6.15891
PLK1 polo-like kinase 1 -5.96526
C2CD5 C2 calcium-dependent domain containing 5 -5.22162
CASP3 caspase 3, apoptosis-related cysteine peptidase -4.83836
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.76054
PSRC1 proline/serine-rich coiled-coil 1 -4.70616
CCNB1 cyclin B1 -4.59308
RXYLT1 ribitol xylosyltransferase 1 -4.58115
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -4.55468
NLRP2B NLR family pyrin domain containing 2B -4.28298
ZDHHC6 zinc finger, DHHC-type containing 6 -4.09075
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.06793
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -4.05707
FASTKD5 FAST kinase domains 5 -4.00808
FGFR4 fibroblast growth factor receptor 4 -3.94823
RUVBL1 RuvB-like AAA ATPase 1 -3.92989
CD320 CD320 molecule -3.91184
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.79967
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.77116
TOP2A topoisomerase (DNA) II alpha 170kDa -3.6803
INTS3 integrator complex subunit 3 -3.62614
CCNA2 cyclin A2 -3.59611
TRAP1 TNF receptor-associated protein 1 -3.49353
PYGL phosphorylase, glycogen, liver -3.45777
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.43955
LBR lamin B receptor -3.43052
AURKB aurora kinase B -3.40359
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.17529
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -3.14629
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.12905
ADI1 acireductone dioxygenase 1 -3.09044
MRPS2 mitochondrial ribosomal protein S2 -3.07734
PECR peroxisomal trans-2-enoyl-CoA reductase -3.03949
TCERG1 transcription elongation regulator 1 -3.03387
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.01175
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.98947
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.97669
NIT1 nitrilase 1 -2.96578
MELK maternal embryonic leucine zipper kinase -2.94545
CDK1 cyclin-dependent kinase 1 -2.84346
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.79831
ATXN2 ataxin 2 -2.79688
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.77773
BIRC5 baculoviral IAP repeat containing 5 -2.76406
ZW10 zw10 kinetochore protein -2.76099
PCNA proliferating cell nuclear antigen -2.75826
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.69951
TBC1D31 TBC1 domain family, member 31 -2.69937
SOAT2 sterol O-acyltransferase 2 -2.69312
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.68657
DBF4 DBF4 zinc finger -2.68574
BCCIP BRCA2 and CDKN1A interacting protein -2.6669
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.65895
UBE2C ubiquitin-conjugating enzyme E2C -2.64109
UBE3C ubiquitin protein ligase E3C -2.6125
ELAVL1 ELAV like RNA binding protein 1 -2.58875
PRUNE1 prune exopolyphosphatase 1 -2.585
GALE UDP-galactose-4-epimerase -2.53017
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.50056
C5 complement component 5 -2.49879
ERC1 ELKS/RAB6-interacting/CAST family member 1 -2.46856
NUP85 nucleoporin 85kDa -2.44696
ITGB1BP1 integrin beta 1 binding protein 1 -2.42123
CEP55 centrosomal protein 55kDa -2.41514
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.39907
CDK4 cyclin-dependent kinase 4 -2.38062
MBL2 mannose-binding lectin (protein C) 2, soluble -2.37886
CDKN3 cyclin-dependent kinase inhibitor 3 -2.36531
TCTN1 tectonic family member 1 -2.3533
RIDA reactive intermediate imine deaminase A homolog -2.34344
POLR1G RNA polymerase I subunit G -2.33865
ZNF200 zinc finger protein 200 -2.3229
RAB20 RAB20, member RAS oncogene family -2.3141
CFHR5 complement factor H-related 5 -2.30479
PKDREJ polycystin (PKD) family receptor for egg jelly -2.28515
CHI3L2 chitinase 3-like 2 -2.27364
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.26954
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.2682
POLR3B polymerase (RNA) III (DNA directed) polypeptide B -2.265
TUBD1 tubulin, delta 1 -2.26415
FBXO5 F-box protein 5 -2.26348
YAF2 YY1 associated factor 2 -2.25136
SOBP sine oculis binding protein homolog (Drosophila) -2.24338
STIMATE STIM activating enhancer -2.22556
TMEM161A transmembrane protein 161A -2.22526
RGS2 regulator of G-protein signaling 2 -2.22277
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.20311
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -2.2012
DDIT4 DNA-damage-inducible transcript 4 -2.19807
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -2.19652
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.19273
ARB2A ARB2 cotranscriptional regulator A -2.19179
C8A complement component 8, alpha polypeptide -2.18174
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -2.18147
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -2.16789
PIPOX pipecolic acid oxidase -2.16364
ENOPH1 enolase-phosphatase 1 -2.16037
NR2E1 nuclear receptor subfamily 2, group E, member 1 -2.155
XPOT exportin, tRNA -2.146
NENF neudesin neurotrophic factor -2.12585
ASF1B anti-silencing function 1B histone chaperone -2.12373
RXRA retinoid X receptor, alpha -2.11597
MVD mevalonate (diphospho) decarboxylase -2.11405
COG4 component of oligomeric golgi complex 4 -2.10343
F9 coagulation factor IX -2.1032
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.09803
RITA1 RBPJ interacting and tubulin associated 1 -2.08202
A1CF APOBEC1 complementation factor -2.07631
STX4 syntaxin 4 -2.06487
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.06088
HADH hydroxyacyl-CoA dehydrogenase -2.05652
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.0518
INHBE inhibin, beta E -2.05046
GNAS GNAS complex locus -2.04743
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.04348
NUP62 nucleoporin 62kDa -2.03705
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.02554
PBK PDZ binding kinase -2.0255
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.01581
PYCR1 pyrroline-5-carboxylate reductase 1 -2.01412
TFDP1 transcription factor Dp-1 -2.01072
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -2.00227
RACGAP1 Rac GTPase activating protein 1 -2.00219