CRCGN013_HEPG2_24H:H20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pyrimethamine 20.3 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

200 genes differentially expressed following the CRCGN013_HEPG2_24H:H20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 9.54781
LCN2 lipocalin 2 8.70551
TIMP2 TIMP metallopeptidase inhibitor 2 6.25879
CNPY3 canopy FGF signaling regulator 3 6.10128
KIFBP kinesin family binding protein 6.06636
NPDC1 neural proliferation, differentiation and control, 1 5.7862
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 5.60799
S100A4 S100 calcium binding protein A4 5.49897
DYNLT3 dynein, light chain, Tctex-type 3 5.21093
IER3 immediate early response 3 5.11063
FHL2 four and a half LIM domains 2 4.62978
NOTCH1 notch 1 4.55174
EDN1 endothelin 1 4.39518
GLRX glutaredoxin (thioltransferase) 4.274
SCRN1 secernin 1 3.98891
ACOT9 acyl-CoA thioesterase 9 3.92796
INPP1 inositol polyphosphate-1-phosphatase 3.89499
TUBB6 tubulin, beta 6 class V 3.88423
ADAM10 ADAM metallopeptidase domain 10 3.67152
LGALS8 lectin, galactoside-binding, soluble, 8 3.60115
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.58232
PNKP polynucleotide kinase 3'-phosphatase 3.57474
IGFBP3 insulin-like growth factor binding protein 3 3.42045
GOLT1B golgi transport 1B 3.35243
MVP major vault protein 3.35041
SQOR sulfide quinone oxidoreductase 3.30354
E2F2 E2F transcription factor 2 3.13809
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 3.10296
NPC1 Niemann-Pick disease, type C1 3.09218
KHDC4 KH domain containing 4, pre-mRNA splicing factor 3.07865
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 3.07654
TBP TATA box binding protein 3.01254
CXCL2 chemokine (C-X-C motif) ligand 2 3.0019
DUSP6 dual specificity phosphatase 6 2.94737
CARMIL1 capping protein regulator and myosin 1 linker 1 2.93049
ANO10 anoctamin 10 2.92006
LRP10 low density lipoprotein receptor-related protein 10 2.85759
TWF2 twinfilin actin binding protein 2 2.7725
TRIB1 tribbles pseudokinase 1 2.71745
CDK7 cyclin-dependent kinase 7 2.68809
VAT1 vesicle amine transport 1 2.64387
SSBP2 single-stranded DNA binding protein 2 2.62172
PLSCR1 phospholipid scramblase 1 2.60988
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.50641
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.46912
MYLK myosin light chain kinase 2.41852
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 2.41299
TGFB1I1 transforming growth factor beta 1 induced transcript 1 2.4112
HLA-DRA major histocompatibility complex, class II, DR alpha 2.40973
SLC75A1 solute carrier family 75 member 1 2.37798
ITFG1 integrin alpha FG-GAP repeat containing 1 2.35918
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.33196
SPAG7 sperm associated antigen 7 2.29694
AMDHD2 amidohydrolase domain containing 2 2.28316
GPR183 G protein-coupled receptor 183 2.26735
GATA2 GATA binding protein 2 2.21291
KANK3 KN motif and ankyrin repeat domains 3 2.19053
TERF2IP telomeric repeat binding factor 2, interacting protein 2.17308
PRAF2 PRA1 domain family, member 2 2.1695
MICALL1 MICAL-like 1 2.12694
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 2.12638
SYF2 SYF2 pre-mRNA-splicing factor 2.12244
TPD52L2 tumor protein D52-like 2 2.11286
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.10267
NANOS3 nanos homolog 3 (Drosophila) 2.06001
CAVIN2 caveolae associated protein 2 2.05058
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.04821
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.04819
FXYD2 FXYD domain containing ion transport regulator 2 2.03239
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 2.03187
TUBG2 tubulin, gamma 2 2.03143
TIAM1 T-cell lymphoma invasion and metastasis 1 2.03086
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit 2.02079
IL7R interleukin 7 receptor 2.01

decreased expression

Symbol Name Standardized Value
ISOC1 isochorismatase domain containing 1 -6.93174
FASTKD5 FAST kinase domains 5 -6.65212
ADI1 acireductone dioxygenase 1 -6.59274
NT5DC2 5'-nucleotidase domain containing 2 -6.53671
ANKRD10 ankyrin repeat domain 10 -5.89081
ZW10 zw10 kinetochore protein -5.78091
B4GAT1 beta-1,4-glucuronyltransferase 1 -5.05009
CDC20 cell division cycle 20 -4.90895
CCNB1 cyclin B1 -4.83005
RXYLT1 ribitol xylosyltransferase 1 -4.64321
RPS4Y1 ribosomal protein S4, Y-linked 1 -4.45578
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.43727
TOP2A topoisomerase (DNA) II alpha 170kDa -4.33521
AURKB aurora kinase B -3.96047
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -3.95559
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.9107
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -3.81366
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.76728
PECR peroxisomal trans-2-enoyl-CoA reductase -3.67967
PSRC1 proline/serine-rich coiled-coil 1 -3.66709
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.65181
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -3.63806
TRAP1 TNF receptor-associated protein 1 -3.6097
NIT1 nitrilase 1 -3.59015
RUVBL1 RuvB-like AAA ATPase 1 -3.57712
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.56773
NLRP2B NLR family pyrin domain containing 2B -3.54644
CDK1 cyclin-dependent kinase 1 -3.50952
CASP3 caspase 3, apoptosis-related cysteine peptidase -3.4205
LDHD lactate dehydrogenase D -3.34417
ZNF586 zinc finger protein 586 -3.31836
CCNA2 cyclin A2 -3.30736
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.28138
PLK1 polo-like kinase 1 -3.25773
MELK maternal embryonic leucine zipper kinase -3.2349
INTS3 integrator complex subunit 3 -3.2252
RPP38 ribonuclease P/MRP 38kDa subunit -3.14739
ICAM3 intercellular adhesion molecule 3 -3.07874
TRIB3 tribbles pseudokinase 3 -3.07008
GALE UDP-galactose-4-epimerase -3.02495
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.01657
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.97266
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.95754
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.93519
HSPB1 heat shock 27kDa protein 1 -2.88662
CRELD2 cysteine-rich with EGF-like domains 2 -2.84742
LBR lamin B receptor -2.84404
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.76273
ZDHHC6 zinc finger, DHHC-type containing 6 -2.75801
ATXN2 ataxin 2 -2.70648
PSENEN presenilin enhancer gamma secretase subunit -2.70275
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -2.68644
GFRA3 GDNF family receptor alpha 3 -2.63926
DDIT4 DNA-damage-inducible transcript 4 -2.62963
PCNA proliferating cell nuclear antigen -2.62133
HADH hydroxyacyl-CoA dehydrogenase -2.61714
WDR7 WD repeat domain 7 -2.60893
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.54396
GTF2A2 general transcription factor IIA, 2, 12kDa -2.54063
COG4 component of oligomeric golgi complex 4 -2.53782
TOMM70 translocase of outer mitochondrial membrane 70 -2.51341
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -2.50751
FKBP4 FK506 binding protein 4, 59kDa -2.49204
TBC1D31 TBC1 domain family, member 31 -2.4812
OVOL2 ovo-like zinc finger 2 -2.48024
PRMT3 protein arginine methyltransferase 3 -2.46629
HMOX1 heme oxygenase 1 -2.41681
KIF11 kinesin family member 11 -2.40995
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.39404
RHEB Ras homolog enriched in brain -2.38651
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 -2.38263
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 -2.3807
MCM10 minichromosome maintenance complex component 10 -2.37552
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.37069
PGRMC1 progesterone receptor membrane component 1 -2.36719
ZNF318 zinc finger protein 318 -2.36493
PYGL phosphorylase, glycogen, liver -2.34753
TMEM147 transmembrane protein 147 -2.33008
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 -2.329
KIF4A kinesin family member 4A -2.32718
BIRC5 baculoviral IAP repeat containing 5 -2.27645
PMCH pro-melanin-concentrating hormone -2.23274
SAMM50 SAMM50 sorting and assembly machinery component -2.23021
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.22077
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.21757
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.21368
ECH1 enoyl CoA hydratase 1, peroxisomal -2.18085
NR1I3 nuclear receptor subfamily 1, group I, member 3 -2.17078
PARPBP PARP1 binding protein -2.16778
CCDC86 coiled-coil domain containing 86 -2.16621
C2CD5 C2 calcium-dependent domain containing 5 -2.15757
CDK4 cyclin-dependent kinase 4 -2.14604
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.14507
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.13781
CDKN3 cyclin-dependent kinase inhibitor 3 -2.1345
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.13322
DIO3 deiodinase, iodothyronine, type III -2.12739
GEMIN6 gem (nuclear organelle) associated protein 6 -2.12421
ELAVL1 ELAV like RNA binding protein 1 -2.12089
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 -2.11874
NUP37 nucleoporin 37kDa -2.11592
SERTAD3 SERTA domain containing 3 -2.09964
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) -2.08813
FGFR4 fibroblast growth factor receptor 4 -2.08794
TCTN1 tectonic family member 1 -2.08728
ERCC6L excision repair cross-complementation group 6-like -2.08384
DRC9 dynein regulatory complex subunit 9 -2.08171
PIR pirin (iron-binding nuclear protein) -2.07989
IDE insulin-degrading enzyme -2.07935
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.07761
TMEM177 transmembrane protein 177 -2.07388
SPA17 sperm autoantigenic protein 17 -2.07049
NBPF19 neuroblastoma breakpoint family, member 19 -2.06733
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -2.05893
PIGN phosphatidylinositol glycan anchor biosynthesis, class N -2.05608
ZNF146 zinc finger protein 146 -2.05175
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.04316
UBE2C ubiquitin-conjugating enzyme E2C -2.02937
KIF18B kinesin family member 18B -2.02335
EGF epidermal growth factor -2.02292
TRMT5 tRNA methyltransferase 5 -2.01913
MAP7 microtubule-associated protein 7 -2.01564
TFDP1 transcription factor Dp-1 -2.00957
BCCIP BRCA2 and CDKN1A interacting protein -2.0083
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 -2.00319
RPAP2 RNA polymerase II associated protein 2 -2.00126