CRCGN013_HEPG2_24H:H21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pyrimethamine 10.15 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

196 genes differentially expressed following the CRCGN013_HEPG2_24H:H21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 7.17798
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.77595
CNPY3 canopy FGF signaling regulator 3 6.7441
CDPF1 cysteine-rich, DPF motif domain containing 1 6.72356
NPDC1 neural proliferation, differentiation and control, 1 6.04142
ANO1 anoctamin 1, calcium activated chloride channel 5.77688
GLRX glutaredoxin (thioltransferase) 4.99551
KLHL21 kelch-like family member 21 4.55193
TIMP2 TIMP metallopeptidase inhibitor 2 4.52369
C2CD2 C2 calcium-dependent domain containing 2 4.21658
PNKP polynucleotide kinase 3'-phosphatase 4.16868
IER3 immediate early response 3 4.1592
NPC1 Niemann-Pick disease, type C1 4.13191
EVL Enah/Vasp-like 4.11459
S100A4 S100 calcium binding protein A4 4.01511
ACOT9 acyl-CoA thioesterase 9 3.97854
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.8648
LGALS8 lectin, galactoside-binding, soluble, 8 3.85406
CCDC85B coiled-coil domain containing 85B 3.77357
LSR lipolysis stimulated lipoprotein receptor 3.72102
EDN1 endothelin 1 3.71893
MVP major vault protein 3.68577
KIFBP kinesin family binding protein 3.62956
DUSP6 dual specificity phosphatase 6 3.51157
INPP1 inositol polyphosphate-1-phosphatase 3.42785
SLC75A1 solute carrier family 75 member 1 3.34474
ADRB2 adrenoceptor beta 2, surface 3.28423
CIAO3 cytosolic iron-sulfur assembly component 3 3.14465
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.12354
CBR1 carbonyl reductase 1 3.02947
MYLK myosin light chain kinase 3.01615
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.99322
LRP10 low density lipoprotein receptor-related protein 10 2.98001
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.96211
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.88178
TRIB1 tribbles pseudokinase 1 2.84343
SQOR sulfide quinone oxidoreductase 2.83219
MICALL1 MICAL-like 1 2.8176
PRR15L proline rich 15-like 2.79587
SAV1 salvador family WW domain containing protein 1 2.76393
MOK MOK protein kinase 2.71481
POLR1D polymerase (RNA) I polypeptide D, 16kDa 2.65406
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.65358
VAT1 vesicle amine transport 1 2.64048
SLC35F2 solute carrier family 35, member F2 2.62975
GOLT1B golgi transport 1B 2.62618
FBXO7 F-box protein 7 2.58007
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 2.53368
HOXC6 homeobox C6 2.51299
CDC45 cell division cycle 45 2.40867
IGFBP3 insulin-like growth factor binding protein 3 2.3878
SSBP2 single-stranded DNA binding protein 2 2.37086
TWF2 twinfilin actin binding protein 2 2.35319
PROCR protein C receptor, endothelial 2.34824
POLH polymerase (DNA directed), eta 2.3258
YIPF3 Yip1 domain family, member 3 2.31093
PRSS22 protease, serine, 22 2.29333
BPGM 2,3-bisphosphoglycerate mutase 2.28794
HIP1R huntingtin interacting protein 1 related 2.27819
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 2.24528
FXYD2 FXYD domain containing ion transport regulator 2 2.24194
FCHO1 FCH domain only 1 2.21568
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 2.20935
TRPM4 transient receptor potential cation channel, subfamily M, member 4 2.20823
HSPA1A heat shock 70kDa protein 1A 2.18865
BAMBI BMP and activin membrane-bound inhibitor 2.18854
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.18747
P3H3 prolyl 3-hydroxylase 3 2.18188
PLA1A phospholipase A1 member A 2.18015
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 2.16553
SPAG7 sperm associated antigen 7 2.15754
DIPK1A divergent protein kinase domain 1A 2.15632
HR hair growth associated 2.14329
SMAD3 SMAD family member 3 2.13767
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.10317
TBC1D15 TBC1 domain family, member 15 2.09906
PTCRA pre T-cell antigen receptor alpha 2.09734
PALM2AKAP2 PALM2 and AKAP2 fusion 2.09194
ITGB5 integrin, beta 5 2.09186
MACF1 microtubule-actin crosslinking factor 1 2.09049
STK32B serine/threonine kinase 32B 2.07213
RIOK3 RIO kinase 3 2.04637
SLAMF7 SLAM family member 7 2.04525
RALB v-ral simian leukemia viral oncogene homolog B 2.03873
TOMM34 translocase of outer mitochondrial membrane 34 2.03815
JUP junction plakoglobin 2.03778
MZB1 marginal zone B and B1 cell-specific protein 2.0169

decreased expression

Symbol Name Standardized Value
ANKRD10 ankyrin repeat domain 10 -9.36925
GNAS GNAS complex locus -7.60212
NT5DC2 5'-nucleotidase domain containing 2 -6.96492
PSRC1 proline/serine-rich coiled-coil 1 -5.14282
CDC20 cell division cycle 20 -5.10413
ISOC1 isochorismatase domain containing 1 -4.93744
ARID5B AT rich interactive domain 5B (MRF1-like) -4.8591
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.74479
COG4 component of oligomeric golgi complex 4 -4.72084
TCTN1 tectonic family member 1 -4.25921
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -4.18147
AURKB aurora kinase B -3.92911
GALE UDP-galactose-4-epimerase -3.89182
TRIB3 tribbles pseudokinase 3 -3.88817
RXYLT1 ribitol xylosyltransferase 1 -3.87159
FASTKD5 FAST kinase domains 5 -3.81858
TRAP1 TNF receptor-associated protein 1 -3.74783
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -3.74615
RUVBL1 RuvB-like AAA ATPase 1 -3.67175
ICAM3 intercellular adhesion molecule 3 -3.64495
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -3.64492
NRIP1 nuclear receptor interacting protein 1 -3.56752
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -3.4585
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.42407
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.38923
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.38259
NIT1 nitrilase 1 -3.36616
TCERG1 transcription elongation regulator 1 -3.36361
ZW10 zw10 kinetochore protein -3.19431
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -3.15985
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -3.15976
CCNB2 cyclin B2 -3.14154
NLRP2B NLR family pyrin domain containing 2B -3.09727
LDHD lactate dehydrogenase D -3.04453
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -3.01206
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.9432
MELK maternal embryonic leucine zipper kinase -2.84533
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.82711
TXNDC9 thioredoxin domain containing 9 -2.81883
FBXL12 F-box and leucine-rich repeat protein 12 -2.8161
OXA1L oxidase (cytochrome c) assembly 1-like -2.79881
CCNA2 cyclin A2 -2.78708
TSPAN4 tetraspanin 4 -2.76652
PYGL phosphorylase, glycogen, liver -2.74241
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.72666
TOP2A topoisomerase (DNA) II alpha 170kDa -2.7232
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.70615
PLK1 polo-like kinase 1 -2.70368
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.63527
DDIT4 DNA-damage-inducible transcript 4 -2.63391
IFRD2 interferon-related developmental regulator 2 -2.59312
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.56964
PECR peroxisomal trans-2-enoyl-CoA reductase -2.54105
CCNE1 cyclin E1 -2.53356
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.52445
RPP38 ribonuclease P/MRP 38kDa subunit -2.52213
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.50479
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa -2.45692
KDM3A lysine (K)-specific demethylase 3A -2.45246
MPZL2 myelin protein zero-like 2 -2.44105
INTS3 integrator complex subunit 3 -2.43747
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.43201
ECH1 enoyl CoA hydratase 1, peroxisomal -2.41023
CCNB1 cyclin B1 -2.40461
PAX6 paired box 6 -2.39814
ZDHHC6 zinc finger, DHHC-type containing 6 -2.35733
SESN1 sestrin 1 -2.34014
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.33899
GTF2A2 general transcription factor IIA, 2, 12kDa -2.32462
MYL9 myosin, light chain 9, regulatory -2.31374
STX4 syntaxin 4 -2.30706
ASF1B anti-silencing function 1B histone chaperone -2.28154
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.27877
MAPK9 mitogen-activated protein kinase 9 -2.27104
BAX BCL2-associated X protein -2.26771
BIRC5 baculoviral IAP repeat containing 5 -2.25142
HADH hydroxyacyl-CoA dehydrogenase -2.23392
UBE3C ubiquitin protein ligase E3C -2.21786
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.19054
OSBPL11 oxysterol binding protein-like 11 -2.16914
PCSK1 proprotein convertase subtilisin/kexin type 1 -2.16552
HMOX1 heme oxygenase 1 -2.15945
ACP2 acid phosphatase 2, lysosomal -2.14919
ZNF623 zinc finger protein 623 -2.12662
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.11618
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 -2.11319
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 -2.10928
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.09537
ELAC2 elaC ribonuclease Z 2 -2.09317
NDFIP1 Nedd4 family interacting protein 1 -2.08681
COL3A1 collagen, type III, alpha 1 -2.07757
SRR serine racemase -2.07545
LOC128966622 putative protein N-methyltransferase FAM86B2 -2.0748
AUNIP aurora kinase A and ninein interacting protein -2.07391
CARD8 caspase recruitment domain family, member 8 -2.07016
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.06394
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.06365
C5 complement component 5 -2.06215
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -2.06076
WDR73 WD repeat domain 73 -2.0551
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) -2.04218
LMAN2L lectin, mannose-binding 2-like -2.0386
CCDC15 coiled-coil domain containing 15 -2.03619
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.02812
TMPRSS6 transmembrane protease, serine 6 -2.02198
GAMT guanidinoacetate N-methyltransferase -2.02003
CEP70 centrosomal protein 70kDa -2.00714
MTARC1 mitochondrial amidoxime reducing component 1 -2.00489
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -2.00375