CRCGN013_HEPG2_24H:H22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pyrimethamine 5.08 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

174 genes differentially expressed following the CRCGN013_HEPG2_24H:H22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CNPY3 canopy FGF signaling regulator 3 6.4163
NPDC1 neural proliferation, differentiation and control, 1 5.28669
LCN2 lipocalin 2 5.24352
INPP1 inositol polyphosphate-1-phosphatase 4.96491
IER3 immediate early response 3 4.42923
KIFBP kinesin family binding protein 4.3956
CDC45 cell division cycle 45 4.38684
GLRX glutaredoxin (thioltransferase) 4.38521
TIMP2 TIMP metallopeptidase inhibitor 2 4.28326
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 4.14565
ACOT9 acyl-CoA thioesterase 9 4.03551
UBQLN2 ubiquilin 2 4.01809
PPARG peroxisome proliferator-activated receptor gamma 4.01764
S100A4 S100 calcium binding protein A4 3.76784
LGALS8 lectin, galactoside-binding, soluble, 8 3.68281
C2CD2 C2 calcium-dependent domain containing 2 3.56745
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 3.40649
NOTCH1 notch 1 3.36061
TSPAN4 tetraspanin 4 3.28421
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.25737
RAB21 RAB21, member RAS oncogene family 3.15754
DUSP6 dual specificity phosphatase 6 3.1546
CBR3 carbonyl reductase 3 2.9532
CDPF1 cysteine-rich, DPF motif domain containing 1 2.87169
EVL Enah/Vasp-like 2.84258
CEMIP2 cell migration inducing hyaluronidase 2 2.78143
MINDY1 MINDY lysine 48 deubiquitinase 1 2.76493
LYN LYN proto-oncogene, Src family tyrosine kinase 2.75507
SSBP2 single-stranded DNA binding protein 2 2.72515
SPAG7 sperm associated antigen 7 2.725
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.60905
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.55392
KLHL21 kelch-like family member 21 2.51437
MVP major vault protein 2.50584
RALB v-ral simian leukemia viral oncogene homolog B 2.50191
TRIB1 tribbles pseudokinase 1 2.49506
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.46832
SCRN1 secernin 1 2.42541
CCL2 chemokine (C-C motif) ligand 2 2.38941
CTSL cathepsin L 2.3777
ITGB5 integrin, beta 5 2.36636
FBXO7 F-box protein 7 2.34886
CDK7 cyclin-dependent kinase 7 2.322
TREM1 triggering receptor expressed on myeloid cells 1 2.31775
CHN1 chimerin 1 2.31505
GOLT1B golgi transport 1B 2.30877
OFD1 oral-facial-digital syndrome 1 2.30258
TUBB6 tubulin, beta 6 class V 2.28815
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.28111
EDN1 endothelin 1 2.27235
CGRRF1 cell growth regulator with ring finger domain 1 2.24157
PLSCR1 phospholipid scramblase 1 2.22992
MOK MOK protein kinase 2.22676
SQOR sulfide quinone oxidoreductase 2.2047
BPGM 2,3-bisphosphoglycerate mutase 2.19423
CASC3 cancer susceptibility candidate 3 2.19295
CDKN2A cyclin-dependent kinase inhibitor 2A 2.19269
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 2.14783
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.13594
YIPF3 Yip1 domain family, member 3 2.10926
PHLDA2 pleckstrin homology-like domain, family A, member 2 2.07686
NPC1 Niemann-Pick disease, type C1 2.07478
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 2.05911
BECN1 beclin 1, autophagy related 2.05347
MRPS10 mitochondrial ribosomal protein S10 2.04784
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) 2.0235
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.02257
HLA-DRA major histocompatibility complex, class II, DR alpha 2.01608
LOC124907782 dual specificity protein phosphatase 22 2.01032

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -7.57285
NT5DC2 5'-nucleotidase domain containing 2 -6.07224
CDC20 cell division cycle 20 -5.5869
ISOC1 isochorismatase domain containing 1 -4.94516
PSRC1 proline/serine-rich coiled-coil 1 -4.68636
FABP5 fatty acid binding protein 5 (psoriasis-associated) -4.65681
CCDC86 coiled-coil domain containing 86 -4.33398
AURKB aurora kinase B -4.19845
CD320 CD320 molecule -3.94795
ICAM3 intercellular adhesion molecule 3 -3.90009
FGFR4 fibroblast growth factor receptor 4 -3.73723
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.63321
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.51698
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -3.49624
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -3.4371
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.41445
FASTKD5 FAST kinase domains 5 -3.29186
COG4 component of oligomeric golgi complex 4 -3.27538
NRIP1 nuclear receptor interacting protein 1 -3.19118
PCNA proliferating cell nuclear antigen -3.16981
MAP7 microtubule-associated protein 7 -3.14291
OXA1L oxidase (cytochrome c) assembly 1-like -2.91133
HSPB1 heat shock 27kDa protein 1 -2.90803
UBE3C ubiquitin protein ligase E3C -2.9
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.89011
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.88663
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.88656
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.87419
MRPS2 mitochondrial ribosomal protein S2 -2.86434
RPS5 ribosomal protein S5 -2.85721
CCNB2 cyclin B2 -2.76051
DDIT4 DNA-damage-inducible transcript 4 -2.7584
YME1L1 YME1-like 1 ATPase -2.70005
ANKRD10 ankyrin repeat domain 10 -2.69623
TRAP1 TNF receptor-associated protein 1 -2.67984
EGF epidermal growth factor -2.66686
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.60061
RXYLT1 ribitol xylosyltransferase 1 -2.55964
KIF14 kinesin family member 14 -2.55494
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.53859
LDHD lactate dehydrogenase D -2.50913
INTS3 integrator complex subunit 3 -2.50581
MELK maternal embryonic leucine zipper kinase -2.47968
NISCH nischarin -2.46436
NCAPD2 non-SMC condensin I complex, subunit D2 -2.4219
JAM2 junctional adhesion molecule 2 -2.37838
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 -2.35965
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.33683
RYR3 ryanodine receptor 3 -2.33174
PYGL phosphorylase, glycogen, liver -2.31873
LGALS12 lectin, galactoside-binding, soluble, 12 -2.29443
ELAVL1 ELAV like RNA binding protein 1 -2.28008
BBS1 Bardet-Biedl syndrome 1 -2.26926
BAX BCL2-associated X protein -2.2637
GLP2R glucagon-like peptide 2 receptor -2.25918
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.25556
NLRP2B NLR family pyrin domain containing 2B -2.25273
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.24635
RUVBL1 RuvB-like AAA ATPase 1 -2.24567
CUL1 cullin 1 -2.23537
TCHH trichohyalin -2.22912
GTF2IRD2B GTF2I repeat domain containing 2B -2.21712
NENF neudesin neurotrophic factor -2.20773
RAPSN receptor-associated protein of the synapse -2.18919
CNGA3 cyclic nucleotide gated channel alpha 3 -2.1877
ZIM2 zinc finger, imprinted 2 -2.18752
TENT5A terminal nucleotidyltransferase 5A -2.1856
TMEM109 transmembrane protein 109 -2.18456
SPHK2 sphingosine kinase 2 -2.18177
RAI14 retinoic acid induced 14 -2.17399
POU3F2 POU class 3 homeobox 2 -2.17103
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.15948
SYCP1 synaptonemal complex protein 1 -2.15404
MEN1 multiple endocrine neoplasia I -2.13817
CXADR coxsackie virus and adenovirus receptor -2.13086
KHDC1L KH homology domain containing 1-like -2.12312
PRAMEF13 PRAME family member 13 -2.12183
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 -2.11918
RNF32 ring finger protein 32 -2.11894
KRT37 keratin 37, type I -2.11708
CCNB1 cyclin B1 -2.10614
CCNA2 cyclin A2 -2.09419
ONECUT2 one cut homeobox 2 -2.09261
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.08722
DPPA4 developmental pluripotency associated 4 -2.08703
RPL27A ribosomal protein L27a -2.08592
CDK4 cyclin-dependent kinase 4 -2.08358
LECT2 leukocyte cell-derived chemotaxin 2 -2.0792
VAT1 vesicle amine transport 1 -2.07797
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 -2.07485
ZNF586 zinc finger protein 586 -2.06946
AMELY amelogenin, Y-linked -2.05862
CATSPERB catsper channel auxiliary subunit beta -2.05314
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 -2.05194
ZFY zinc finger protein, Y-linked -2.04359
ZXDB zinc finger, X-linked, duplicated B -2.04218
TESMIN testis expressed metallothionein like protein -2.03962
AQP4 aquaporin 4 -2.0384
ZNF287 zinc finger protein 287 -2.03285
EFR3B EFR3 homolog B (S. cerevisiae) -2.0309
RGSL1 regulator of G-protein signaling like 1 -2.01945
PLK1 polo-like kinase 1 -2.01596
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.0083
VASH2 vasohibin 2 -2.00329
KRT35 keratin 35, type I -2.00172