CRCGN013_HEPG2_24H:H23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pyrimethamine 2.54 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

125 genes differentially expressed following the CRCGN013_HEPG2_24H:H23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KIFBP kinesin family binding protein 6.51917
E2F2 E2F transcription factor 2 6.28401
CHMP6 charged multivesicular body protein 6 6.25977
MYLK myosin light chain kinase 6.14769
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.41612
CNPY3 canopy FGF signaling regulator 3 5.35966
GPER1 G protein-coupled estrogen receptor 1 4.63747
CDPF1 cysteine-rich, DPF motif domain containing 1 4.61247
UBQLN2 ubiquilin 2 4.41699
CHN1 chimerin 1 4.38829
TIMP2 TIMP metallopeptidase inhibitor 2 4.31876
ADGRE5 adhesion G protein-coupled receptor E5 3.83629
PNKP polynucleotide kinase 3'-phosphatase 3.80081
ADAT1 adenosine deaminase, tRNA-specific 1 3.79822
CDC45 cell division cycle 45 3.71809
INPP1 inositol polyphosphate-1-phosphatase 3.62002
ACOT9 acyl-CoA thioesterase 9 3.58996
S100A4 S100 calcium binding protein A4 3.44647
GRWD1 glutamate-rich WD repeat containing 1 3.42305
EGF epidermal growth factor 3.30928
RRAGA Ras-related GTP binding A 3.30574
MVP major vault protein 3.1785
IER3 immediate early response 3 3.16283
CGRRF1 cell growth regulator with ring finger domain 1 3.09242
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 3.0414
CCL2 chemokine (C-C motif) ligand 2 2.95414
GLRX glutaredoxin (thioltransferase) 2.91965
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.82129
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.78261
FHL2 four and a half LIM domains 2 2.75652
GATA3 GATA binding protein 3 2.7246
TIAM1 T-cell lymphoma invasion and metastasis 1 2.71032
TBP TATA box binding protein 2.70542
VAV3 vav 3 guanine nucleotide exchange factor 2.69936
SPAG7 sperm associated antigen 7 2.69909
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.68916
DUSP6 dual specificity phosphatase 6 2.66125
BTK Bruton agammaglobulinemia tyrosine kinase 2.62376
ANO1 anoctamin 1, calcium activated chloride channel 2.61756
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.61635
GSTZ1 glutathione S-transferase zeta 1 2.5612
CTSL cathepsin L 2.56086
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.51646
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 2.3697
FXYD2 FXYD domain containing ion transport regulator 2 2.35904
ERBB3 erb-b2 receptor tyrosine kinase 3 2.35893
SNX7 sorting nexin 7 2.33857
RPP38 ribonuclease P/MRP 38kDa subunit 2.33824
DCTN1 dynactin 1 2.32863
UFM1 ubiquitin-fold modifier 1 2.32384
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.30182
FAT1 FAT atypical cadherin 1 2.28788
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 2.25106
PLSCR1 phospholipid scramblase 1 2.24633
PISD phosphatidylserine decarboxylase 2.23869
EPN2 epsin 2 2.18285
NOSIP nitric oxide synthase interacting protein 2.18152
TRIB1 tribbles pseudokinase 1 2.16453
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 2.13609
LCN2 lipocalin 2 2.12051
TSPAN4 tetraspanin 4 2.11357
GARRE1 granule associated Rac and RHOG effector 1 2.11032
STXBP2 syntaxin binding protein 2 2.10679
SQOR sulfide quinone oxidoreductase 2.0687
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.0426
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 2.04102
CCDC198 coiled-coil domain containing 198 2.03383
ETV2 ets variant 2 2.02443
MRC1 mannose receptor, C type 1 2.01121
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) 2.00541

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -6.08494
NT5DC2 5'-nucleotidase domain containing 2 -5.36834
ISOC1 isochorismatase domain containing 1 -5.30673
GNAS GNAS complex locus -4.57181
CASP3 caspase 3, apoptosis-related cysteine peptidase -4.39349
FABP5 fatty acid binding protein 5 (psoriasis-associated) -4.34432
CCDC86 coiled-coil domain containing 86 -4.19437
TRAP1 TNF receptor-associated protein 1 -4.0353
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.56937
FGFR4 fibroblast growth factor receptor 4 -3.51479
ANKRD10 ankyrin repeat domain 10 -3.29013
AURKB aurora kinase B -3.2661
ZW10 zw10 kinetochore protein -3.24831
LDHD lactate dehydrogenase D -3.16206
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.88837
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.88059
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.87725
RUVBL1 RuvB-like AAA ATPase 1 -2.85758
TM9SF3 transmembrane 9 superfamily member 3 -2.80942
RHEB Ras homolog enriched in brain -2.76981
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.73026
FBXL12 F-box and leucine-rich repeat protein 12 -2.67747
DDIT4 DNA-damage-inducible transcript 4 -2.63355
CRELD2 cysteine-rich with EGF-like domains 2 -2.62597
PSRC1 proline/serine-rich coiled-coil 1 -2.59902
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.59444
PEG10 paternally expressed 10 -2.58273
ZDHHC6 zinc finger, DHHC-type containing 6 -2.5609
GOLT1B golgi transport 1B -2.54886
MELK maternal embryonic leucine zipper kinase -2.44406
TXNDC9 thioredoxin domain containing 9 -2.41065
TRIB3 tribbles pseudokinase 3 -2.3999
DERA deoxyribose-phosphate aldolase (putative) -2.35071
KDM3A lysine (K)-specific demethylase 3A -2.34207
VAT1 vesicle amine transport 1 -2.32699
DNM1L dynamin 1-like -2.27947
PIM2 Pim-2 proto-oncogene, serine/threonine kinase -2.23197
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.22926
UBE3C ubiquitin protein ligase E3C -2.22623
NLRP2B NLR family pyrin domain containing 2B -2.21252
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.18242
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.17483
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.16374
KCTD7 potassium channel tetramerization domain containing 7 -2.13222
TUBB6 tubulin, beta 6 class V -2.10268
AKAP8 A kinase (PRKA) anchor protein 8 -2.10181
MTREX Mtr4 exosome RNA helicase -2.07961
AZIN1 antizyme inhibitor 1 -2.06995
IL6 interleukin 6 -2.04671
COG4 component of oligomeric golgi complex 4 -2.02426
NENF neudesin neurotrophic factor -2.02345
PRPF19 pre-mRNA processing factor 19 -2.0194
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 -2.01375
PCNA proliferating cell nuclear antigen -2.0101
CCNB2 cyclin B2 -2.00042