CRCGN013_HEPG2_24H:I02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description aroclor 1260 19.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

62 genes differentially expressed following the CRCGN013_HEPG2_24H:I02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.5381
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.29601
CXCL2 chemokine (C-X-C motif) ligand 2 4.21973
STIMATE STIM activating enhancer 4.19457
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.09468
RAB11FIP1 RAB11 family interacting protein 1 (class I) 4.035
MAP7 microtubule-associated protein 7 3.92421
MAMLD1 mastermind-like domain containing 1 3.87705
TREM1 triggering receptor expressed on myeloid cells 1 3.78734
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.73689
CNPY3 canopy FGF signaling regulator 3 3.36243
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.2717
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.24416
GSTZ1 glutathione S-transferase zeta 1 3.24357
SFTPB surfactant protein B 3.08167
INTS3 integrator complex subunit 3 2.72127
ADGRE5 adhesion G protein-coupled receptor E5 2.66667
ZNF589 zinc finger protein 589 2.45973
LCN2 lipocalin 2 2.33533
H2BC12 H2B clustered histone 12 2.31959
KLHL9 kelch-like family member 9 2.26982
GPER1 G protein-coupled estrogen receptor 1 2.14023
CHN1 chimerin 1 2.11711
THADA thyroid adenoma associated 2.08523
GATA2 GATA binding protein 2 2.07547
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.05792
LRRC59 leucine rich repeat containing 59 2.04249
VGLL4 vestigial-like family member 4 2.03716
LMO7 LIM domain 7 2.0257
RAB20 RAB20, member RAS oncogene family 2.00399

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
KDM3A lysine (K)-specific demethylase 3A -4.7677
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.55284
PCNA proliferating cell nuclear antigen -4.48057
LAP3 leucine aminopeptidase 3 -4.38378
ZDHHC6 zinc finger, DHHC-type containing 6 -4.12302
ADI1 acireductone dioxygenase 1 -4.07544
GTPBP8 GTP-binding protein 8 (putative) -4.06648
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.02258
GDF15 growth differentiation factor 15 -3.83404
VAT1 vesicle amine transport 1 -3.58321
LDHD lactate dehydrogenase D -3.01914
TXNDC9 thioredoxin domain containing 9 -2.99457
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.95208
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.94926
TBCB tubulin folding cofactor B -2.8672
TRIB3 tribbles pseudokinase 3 -2.83946
GNAS GNAS complex locus -2.8
MAPK13 mitogen-activated protein kinase 13 -2.61417
FGFR4 fibroblast growth factor receptor 4 -2.58875
CRELD2 cysteine-rich with EGF-like domains 2 -2.45992
SMAGP small cell adhesion glycoprotein -2.43957
EIF5 eukaryotic translation initiation factor 5 -2.41746
GRB7 growth factor receptor-bound protein 7 -2.34549
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.25737
TMEM97 transmembrane protein 97 -2.23444
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.2101
CNPY4 canopy FGF signaling regulator 4 -2.09403
TUBA3C tubulin, alpha 3c -2.05689
VPS9D1 VPS9 domain containing 1 -2.03221
COXFA4 cytochrome c oxidase associated subunit FA4 -2.00767
PSENEN presenilin enhancer gamma secretase subunit -2.00406