CRCGN013_HEPG2_24H:I04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description aroclor 1260 4.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

66 genes differentially expressed following the CRCGN013_HEPG2_24H:I04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.7758
CHMP6 charged multivesicular body protein 6 4.03491
LCN2 lipocalin 2 3.9828
CIAO3 cytosolic iron-sulfur assembly component 3 3.62581
CBR3 carbonyl reductase 3 3.42585
CNPY3 canopy FGF signaling regulator 3 3.27671
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.24514
CXCL2 chemokine (C-X-C motif) ligand 2 3.08459
ANO1 anoctamin 1, calcium activated chloride channel 2.98122
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.90643
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.84783
MAST2 microtubule associated serine/threonine kinase 2 2.7498
MCM3 minichromosome maintenance complex component 3 2.65002
SFTPB surfactant protein B 2.50817
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.46487
RRAGA Ras-related GTP binding A 2.43159
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.33373
NOSIP nitric oxide synthase interacting protein 2.30723
FCHO1 FCH domain only 1 2.26912
GSTZ1 glutathione S-transferase zeta 1 2.23677
GPER1 G protein-coupled estrogen receptor 1 2.19097
SSBP2 single-stranded DNA binding protein 2 2.18101
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.14522
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 2.13175
ADRA2C adrenoceptor alpha 2C 2.10972
PENK proenkephalin 2.0774
CHEK2 checkpoint kinase 2 2.06491
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.06457
TBXA2R thromboxane A2 receptor 2.05917
SAYSD1 SAYSVFN motif domain containing 1 2.01224

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -9.97903
LDHD lactate dehydrogenase D -6.79999
SLC35F2 solute carrier family 35, member F2 -5.64843
YME1L1 YME1-like 1 ATPase -5.33648
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.22656
THAP11 THAP domain containing 11 -4.20845
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.93627
NGRN neugrin, neurite outgrowth associated -3.89487
PCNA proliferating cell nuclear antigen -3.85686
ZDHHC6 zinc finger, DHHC-type containing 6 -3.78011
ADI1 acireductone dioxygenase 1 -3.77861
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.69788
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.63929
CCDC86 coiled-coil domain containing 86 -3.57893
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.5323
CHMP4B charged multivesicular body protein 4B -3.23436
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.13965
ZNF586 zinc finger protein 586 -3.07122
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.96686
TXNDC9 thioredoxin domain containing 9 -2.94598
GTPBP8 GTP-binding protein 8 (putative) -2.80584
MAPK13 mitogen-activated protein kinase 13 -2.79181
ZW10 zw10 kinetochore protein -2.69972
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.65176
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.62786
NVL nuclear VCP-like -2.55433
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.51952
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) -2.43253
TRIB3 tribbles pseudokinase 3 -2.33831
KIF21B kinesin family member 21B -2.31747
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.2414
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.229
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.16739
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.12993
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.12021
TRIAP1 TP53 regulated inhibitor of apoptosis 1 -2.10575