CRCGN013_HEPG2_24H:I06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description aroclor 1260 1.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

116 genes differentially expressed following the CRCGN013_HEPG2_24H:I06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PEX11A peroxisomal biogenesis factor 11 alpha 6.63119
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 6.12113
STK10 serine/threonine kinase 10 5.47428
RPP38 ribonuclease P/MRP 38kDa subunit 5.40777
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 5.35649
AMDHD2 amidohydrolase domain containing 2 5.33814
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.95015
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.91476
CARMIL1 capping protein regulator and myosin 1 linker 1 4.81179
E2F2 E2F transcription factor 2 4.79623
STIMATE STIM activating enhancer 4.76584
SYNE2 spectrin repeat containing, nuclear envelope 2 4.70135
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.60242
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.1362
HDGFL3 HDGF like 3 4.08493
LOC122526780 uncharacterized LOC122526780 3.84037
HLA-DRA major histocompatibility complex, class II, DR alpha 3.59476
STXBP2 syntaxin binding protein 2 3.511
ANO1 anoctamin 1, calcium activated chloride channel 3.48354
CIAO3 cytosolic iron-sulfur assembly component 3 3.43196
CHMP6 charged multivesicular body protein 6 3.38022
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.3237
TBXA2R thromboxane A2 receptor 3.20006
INTS3 integrator complex subunit 3 3.09081
NSDHL NAD(P) dependent steroid dehydrogenase-like 3.01864
FZD7 frizzled class receptor 7 3.01618
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.95203
CLDN14 claudin 14 2.87857
HOXD13 homeobox D13 2.82167
MCUR1 mitochondrial calcium uniporter regulator 1 2.82149
GINS3 GINS complex subunit 3 (Psf3 homolog) 2.76467
PLAC1 placenta-specific 1 2.72266
LINS1 lines homolog 1 2.64623
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.58613
PHKG2 phosphorylase kinase, gamma 2 (testis) 2.57716
SOX1 SRY (sex determining region Y)-box 1 2.55963
TTC23 tetratricopeptide repeat domain 23 2.54145
SSTR5 somatostatin receptor 5 2.48395
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 2.44141
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 2.40744
AUNIP aurora kinase A and ninein interacting protein 2.40003
VAMP5 vesicle-associated membrane protein 5 2.34524
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 2.32321
MICALL1 MICAL-like 1 2.30465
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.29516
PRICKLE3 prickle homolog 3 (Drosophila) 2.28917
PRPF18 pre-mRNA processing factor 18 2.25577
MMP15 matrix metallopeptidase 15 (membrane-inserted) 2.25407
MYOM1 myomesin 1 2.25361
PSPN persephin 2.23591
GDE1 glycerophosphodiester phosphodiesterase 1 2.23005
MTNAP1 mitochondrial nucleoid associated protein 1 2.22256
SOCS2 suppressor of cytokine signaling 2 2.21953
RPP40 ribonuclease P/MRP 40kDa subunit 2.21362
NPTXR neuronal pentraxin receptor 2.20612
SRRD SRR1 domain containing 2.20183
RBM42 RNA binding motif protein 42 2.19891
HSFX2 heat shock transcription factor family, X linked 2 2.18614
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 2.18328
PARPBP PARP1 binding protein 2.15297
UBFD1 ubiquitin family domain containing 1 2.11992
ADRA1D adrenoceptor alpha 1D 2.11168
NOSIP nitric oxide synthase interacting protein 2.10967
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) 2.09556
FAAP24 FA core complex associated protein 24 2.09056
NPPB natriuretic peptide B 2.08297
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 2.08234
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 2.07954
PAX3 paired box 3 2.07882
CCL5 chemokine (C-C motif) ligand 5 2.07584
OASL 2'-5'-oligoadenylate synthetase-like 2.07489
ZFYVE21 zinc finger, FYVE domain containing 21 2.07096
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.06633
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 2.05998
RBP3 retinol binding protein 3, interstitial 2.05339
GRIA4 glutamate receptor, ionotropic, AMPA 4 2.04797
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.04645
MCM3 minichromosome maintenance complex component 3 2.03901
PAX9 paired box 9 2.03501
HAMP hepcidin antimicrobial peptide 2.03497
HOXD12 homeobox D12 2.03496
ERCC6L excision repair cross-complementation group 6-like 2.02731
TREH trehalase (brush-border membrane glycoprotein) 2.02582
GPKOW G patch domain and KOW motifs 2.01982
NTNG2 netrin G2 2.00397

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -6.09585
PCNA proliferating cell nuclear antigen -5.84641
RPN1 ribophorin I -5.06533
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.5633
OXA1L oxidase (cytochrome c) assembly 1-like -4.5243
CHMP4B charged multivesicular body protein 4B -4.18916
ZNF586 zinc finger protein 586 -4.01339
RHEB Ras homolog enriched in brain -3.94179
VAT1 vesicle amine transport 1 -3.89864
MAP7 microtubule-associated protein 7 -3.6507
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.62672
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.59787
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.85779
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.8564
CFAP298 cilia and flagella associated protein 298 -2.54603
CCNB2 cyclin B2 -2.4764
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.44672
ZIM3 zinc finger, imprinted 3 -2.41671
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.41341
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.38859
NRIP1 nuclear receptor interacting protein 1 -2.32442
VDAC1 voltage-dependent anion channel 1 -2.23965
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 -2.22838
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.22715
CD1B CD1b molecule -2.16305
IST1 increased sodium tolerance 1 homolog (yeast) -2.13878
GNAS GNAS complex locus -2.1176
PLCD1 phospholipase C, delta 1 -2.0504
RGCC regulator of cell cycle -2.0178
IFNGR1 interferon gamma receptor 1 -2.01359
SAFB scaffold attachment factor B -2.00096