CRCGN013_HEPG2_24H:I08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3-nitropropanoic acid 10.92 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

66 genes differentially expressed following the CRCGN013_HEPG2_24H:I08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 6.81959
MYLK myosin light chain kinase 5.22789
C2CD2 C2 calcium-dependent domain containing 2 4.84717
CHN1 chimerin 1 3.62814
KIF5C kinesin family member 5C 3.23509
CEP57 centrosomal protein 57kDa 3.12855
EAPP E2F-associated phosphoprotein 2.83432
JADE2 jade family PHD finger 2 2.78491
ANO1 anoctamin 1, calcium activated chloride channel 2.73692
UFM1 ubiquitin-fold modifier 1 2.6239
SSBP2 single-stranded DNA binding protein 2 2.58303
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.5323
DIPK1A divergent protein kinase domain 1A 2.52332
LSR lipolysis stimulated lipoprotein receptor 2.51644
PEX11A peroxisomal biogenesis factor 11 alpha 2.43332
BAMBI BMP and activin membrane-bound inhibitor 2.43243
PPARG peroxisome proliferator-activated receptor gamma 2.41575
MMP1 matrix metallopeptidase 1 2.3712
CEMIP2 cell migration inducing hyaluronidase 2 2.27349
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.26595
GATA3 GATA binding protein 3 2.17794
CBR3 carbonyl reductase 3 2.1732
FAM169A family with sequence similarity 169, member A 2.15345
MAP7 microtubule-associated protein 7 2.11645
SINHCAF SIN3-HDAC complex associated factor 2.10775
BAALC brain and acute leukemia, cytoplasmic 2.04161
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.025
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.00977
SMAGP small cell adhesion glycoprotein 2.007

decreased expression

Symbol Name Standardized Value
CHMP4B charged multivesicular body protein 4B -6.2628
GDF15 growth differentiation factor 15 -5.40242
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -5.2192
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.0
UGDH UDP-glucose 6-dehydrogenase -4.95079
PCNA proliferating cell nuclear antigen -4.94036
THAP11 THAP domain containing 11 -4.93832
TRIB3 tribbles pseudokinase 3 -4.68705
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -4.6824
OXA1L oxidase (cytochrome c) assembly 1-like -4.20946
ZMIZ1 zinc finger, MIZ-type containing 1 -4.19946
GNAS GNAS complex locus -3.77772
YME1L1 YME1-like 1 ATPase -3.7636
ZNF586 zinc finger protein 586 -3.63359
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.63088
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.03722
CCNB1 cyclin B1 -2.97446
STAT1 signal transducer and activator of transcription 1, 91kDa -2.92807
COG2 component of oligomeric golgi complex 2 -2.81097
LDHD lactate dehydrogenase D -2.67979
RGS2 regulator of G-protein signaling 2 -2.39719
BAHCC1 BAH domain and coiled-coil containing 1 -2.38587
FAM50A family with sequence similarity 50, member A -2.38032
FES FES proto-oncogene, tyrosine kinase -2.36355
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.25006
PHC1 polyhomeotic homolog 1 (Drosophila) -2.17669
ITGB1BP1 integrin beta 1 binding protein 1 -2.16256
MINDY3 MINDY lysine 48 deubiquitinase 3 -2.11244
PEG10 paternally expressed 10 -2.10076
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.10076
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.07917
SLC16A6 solute carrier family 16, member 6 -2.06049
AKTIP AKT interacting protein -2.05169
ZBTB25 zinc finger and BTB domain containing 25 -2.05043
KIN Kin17 DNA and RNA binding protein -2.03958
OCA2 oculocutaneous albinism II -2.03002
NTF3 neurotrophin 3 -2.02177