| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 3-nitropropanoic acid 5.46 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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67 genes differentially expressed following the CRCGN013_HEPG2_24H:I09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 5.94055 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 4.56952 |
| MOK | MOK protein kinase | 4.52448 |
| CYCS | cytochrome c, somatic | 4.2324 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 4.15391 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 3.821 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 3.74813 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 3.68764 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 3.38455 |
| EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 | 3.20093 |
| DIPK1A | divergent protein kinase domain 1A | 3.09092 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 2.86331 |
| CNOT7 | CCR4-NOT transcription complex, subunit 7 | 2.53963 |
| PRSS53 | protease, serine, 53 | 2.46329 |
| TBP | TATA box binding protein | 2.43858 |
| RIOK2 | RIO kinase 2 | 2.30589 |
| LAG3 | lymphocyte-activation gene 3 | 2.29923 |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 2.29451 |
| CEP57 | centrosomal protein 57kDa | 2.29398 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | 2.28802 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.26594 |
| VDAC1 | voltage-dependent anion channel 1 | 2.21742 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 2.19557 |
| HLTF | helicase-like transcription factor | 2.11153 |
| GALNT12 | polypeptide N-acetylgalactosaminyltransferase 12 | 2.07287 |
| PRPF39 | pre-mRNA processing factor 39 | 2.06789 |
| SLC22A14 | solute carrier family 22, member 14 | 2.04656 |
| PALS1 | protein associated with LIN7 1, MAGUK p55 family member | 2.02276 |
| PLS1 | plastin 1 | 2.01967 |
| ALDH9A1 | aldehyde dehydrogenase 9 family, member A1 | 2.00192 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ADI1 | acireductone dioxygenase 1 | -7.31697 |
| CCNB2 | cyclin B2 | -6.39716 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -6.17362 |
| YME1L1 | YME1-like 1 ATPase | -5.47685 |
| CHMP4B | charged multivesicular body protein 4B | -4.39097 |
| FASTKD5 | FAST kinase domains 5 | -4.01157 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -3.93543 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.8972 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -3.81913 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -3.71645 |
| DNM1L | dynamin 1-like | -3.7093 |
| GDF15 | growth differentiation factor 15 | -3.66062 |
| MRPS2 | mitochondrial ribosomal protein S2 | -3.57545 |
| DSG2 | desmoglein 2 | -3.51433 |
| KDM3A | lysine (K)-specific demethylase 3A | -3.44459 |
| CCNB1 | cyclin B1 | -3.27871 |
| LDHD | lactate dehydrogenase D | -3.27578 |
| TLR4 | toll-like receptor 4 | -3.03481 |
| MEST | mesoderm specific transcript | -3.01546 |
| PIK3R4 | phosphoinositide-3-kinase, regulatory subunit 4 | -2.96668 |
| FGFR4 | fibroblast growth factor receptor 4 | -2.93431 |
| RGS2 | regulator of G-protein signaling 2 | -2.90414 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | -2.89882 |
| TOR1A | torsin family 1, member A (torsin A) | -2.76205 |
| DUSP11 | dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) | -2.71625 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.68818 |
| FLRT3 | fibronectin leucine rich transmembrane protein 3 | -2.52664 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -2.40558 |
| THSD4 | thrombospondin, type I, domain containing 4 | -2.39619 |
| PLEKHF2 | pleckstrin homology domain containing, family F (with FYVE domain) member 2 | -2.32382 |
| CAB39 | calcium binding protein 39 | -2.32001 |
| KCNK3 | potassium channel, two pore domain subfamily K, member 3 | -2.22305 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -2.22122 |
| YARS2 | tyrosyl-tRNA synthetase 2, mitochondrial | -2.20158 |
| LOC124907782 | dual specificity protein phosphatase 22 | -2.05787 |
| TXNDC9 | thioredoxin domain containing 9 | -2.02207 |
| PPP1R26 | protein phosphatase 1, regulatory subunit 26 | -2.00501 |
