CRCGN013_HEPG2_24H:I16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,4-dimethyl-5h-pyrido[4,3-b]indol-3-amine acetate 2.58 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

223 genes differentially expressed following the CRCGN013_HEPG2_24H:I16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 10.0
CDPF1 cysteine-rich, DPF motif domain containing 1 10.0
CNPY3 canopy FGF signaling regulator 3 9.26434
INPP1 inositol polyphosphate-1-phosphatase 6.21534
IER3 immediate early response 3 5.7562
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 5.03895
DDB2 damage-specific DNA binding protein 2, 48kDa 4.79107
TUBB6 tubulin, beta 6 class V 4.44504
IKZF1 IKAROS family zinc finger 1 (Ikaros) 4.00987
FOSL1 FOS-like antigen 1 3.94781
MICALL1 MICAL-like 1 3.63551
PNKP polynucleotide kinase 3'-phosphatase 3.31229
EGR1 early growth response 1 3.2839
IL4R interleukin 4 receptor 3.16947
MAMLD1 mastermind-like domain containing 1 3.09636
BLCAP bladder cancer associated protein 3.08188
PRKCQ protein kinase C, theta 3.06504
ASCC3 activating signal cointegrator 1 complex subunit 3 3.0413
DUSP6 dual specificity phosphatase 6 3.02416
IGFBP3 insulin-like growth factor binding protein 3 2.99448
TIMP2 TIMP metallopeptidase inhibitor 2 2.94972
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.9178
EPHB2 EPH receptor B2 2.82223
S100A4 S100 calcium binding protein A4 2.80456
CIAO3 cytosolic iron-sulfur assembly component 3 2.8014
CEP57 centrosomal protein 57kDa 2.57305
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.57153
SQSTM1 sequestosome 1 2.5586
AEN apoptosis enhancing nuclease 2.54869
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.49911
SOX4 SRY (sex determining region Y)-box 4 2.46883
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.46096
ACOT9 acyl-CoA thioesterase 9 2.45556
CCP110 centriolar coiled coil protein 110kDa 2.42438
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.41079
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.36341
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.34984
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.3425
UBE2A ubiquitin-conjugating enzyme E2A 2.32977
ADRB2 adrenoceptor beta 2, surface 2.32621
UBQLN2 ubiquilin 2 2.26245
WDR44 WD repeat domain 44 2.23764
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.2169
CTSL cathepsin L 2.21037
WFS1 Wolfram syndrome 1 (wolframin) 2.20789
TRIB1 tribbles pseudokinase 1 2.19691
LSR lipolysis stimulated lipoprotein receptor 2.17859
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 2.16449
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 2.12807
CUL7 cullin 7 2.10404
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.08277
LIF leukemia inhibitory factor 2.07989
EIF6 eukaryotic translation initiation factor 6 2.07109
MYO18A myosin XVIIIA 2.07059
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 2.06418
TOMM34 translocase of outer mitochondrial membrane 34 2.04925
CCDC92 coiled-coil domain containing 92 2.03252
EPHA2 EPH receptor A2 2.02829

decreased expression

Symbol Name Standardized Value
ZW10 zw10 kinetochore protein -5.83227
GNAS GNAS complex locus -4.96421
CRELD2 cysteine-rich with EGF-like domains 2 -4.7248
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -4.69439
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.65783
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.51615
ISOC1 isochorismatase domain containing 1 -4.47313
ALDOC aldolase C, fructose-bisphosphate -4.3455
VDAC1 voltage-dependent anion channel 1 -4.16996
FGFR4 fibroblast growth factor receptor 4 -3.89501
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -3.69336
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.60195
PECR peroxisomal trans-2-enoyl-CoA reductase -3.58776
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.49873
CCNB2 cyclin B2 -3.45773
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.45085
PRCP prolylcarboxypeptidase (angiotensinase C) -3.38911
MAPK13 mitogen-activated protein kinase 13 -3.35833
MRPS2 mitochondrial ribosomal protein S2 -3.32645
C2CD5 C2 calcium-dependent domain containing 5 -3.30892
LDHD lactate dehydrogenase D -3.18957
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.07903
PSRC1 proline/serine-rich coiled-coil 1 -3.07149
TCTN1 tectonic family member 1 -3.03709
MTNAP1 mitochondrial nucleoid associated protein 1 -3.00117
TM9SF3 transmembrane 9 superfamily member 3 -2.9936
CTSD cathepsin D -2.84558
PLK1 polo-like kinase 1 -2.82763
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic -2.79385
LBR lamin B receptor -2.73806
NUCB2 nucleobindin 2 -2.69484
SOAT2 sterol O-acyltransferase 2 -2.65007
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.62252
FAM117A family with sequence similarity 117, member A -2.61951
PCNA proliferating cell nuclear antigen -2.61912
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) -2.60788
ANKRD46 ankyrin repeat domain 46 -2.5627
SLC30A10 solute carrier family 30, member 10 -2.51783
RIDA reactive intermediate imine deaminase A homolog -2.49393
GSG1 germ cell associated 1 -2.43821
AURKB aurora kinase B -2.43625
ZNF37A zinc finger protein 37A -2.42357
MYEF2 myelin expression factor 2 -2.41182
PHF24 PHD finger protein 24 -2.39768
ANKRD7 ankyrin repeat domain 7 -2.3899
SYN3 synapsin III -2.37781
GRID2 glutamate receptor, ionotropic, delta 2 -2.37308
SQLE squalene epoxidase -2.3615
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma -2.35265
SCRG1 stimulator of chondrogenesis 1 -2.33741
CABP1 calcium binding protein 1 -2.33444
CYSLTR1 cysteinyl leukotriene receptor 1 -2.33045
PGAP3 post-GPI attachment to proteins 3 -2.31767
SCD stearoyl-CoA desaturase (delta-9-desaturase) -2.31618
THAP9 THAP domain containing 9 -2.31584
HOXD12 homeobox D12 -2.30867
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 -2.29184
MSMO1 methylsterol monooxygenase 1 -2.28122
ADI1 acireductone dioxygenase 1 -2.27864
LIPF lipase, gastric -2.26843
LDHAL6B lactate dehydrogenase A-like 6B -2.26163
TOP2A topoisomerase (DNA) II alpha 170kDa -2.25789
TRPC5 transient receptor potential cation channel, subfamily C, member 5 -2.25721
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 -2.24343
GPRC5B G protein-coupled receptor, class C, group 5, member B -2.2398
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 -2.23884
GK2 glycerol kinase 2 -2.23669
ZNF749 zinc finger protein 749 -2.2361
GRIA1 glutamate receptor, ionotropic, AMPA 1 -2.23229
CCR6 chemokine (C-C motif) receptor 6 -2.23124
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 -2.22636
TEX13A testis expressed 13A -2.22567
SYCP1 synaptonemal complex protein 1 -2.22457
MVD mevalonate (diphospho) decarboxylase -2.22137
OR7C1 olfactory receptor, family 7, subfamily C, member 1 -2.21358
LGMN legumain -2.20879
DGKE diacylglycerol kinase, epsilon 64kDa -2.19042
MROH9 maestro heat-like repeat family member 9 -2.18877
FHL2 four and a half LIM domains 2 -2.18468
PRKN parkin RBR E3 ubiquitin protein ligase -2.18351
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.18186
JPH3 junctophilin 3 -2.18099
LOC122539214 Zinc finger protein LOC122539214 -2.1804
ZNF132 zinc finger protein 132 -2.17962
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A -2.17697
CDH20 cadherin 20, type 2 -2.17603
POU1F1 POU class 1 homeobox 1 -2.16943
KDM4D lysine (K)-specific demethylase 4D -2.16859
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.16857
RPS5 ribosomal protein S5 -2.16656
IMPG1 interphotoreceptor matrix proteoglycan 1 -2.16536
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 -2.16222
TLL1 tolloid-like 1 -2.15638
AMELX amelogenin, X-linked -2.15467
FLT1 fms-related tyrosine kinase 1 -2.15302
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.14644
SPRYD7 SPRY domain containing 7 -2.14624
BCL2L11 BCL2-like 11 (apoptosis facilitator) -2.14491
QTRT1 queuine tRNA-ribosyltransferase 1 -2.13949
GMCL1 germ cell-less, spermatogenesis associated 1 -2.13561
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 -2.13468
EPHA5 EPH receptor A5 -2.13387
NACA2 nascent polypeptide-associated complex alpha subunit 2 -2.13223
NR1H4 nuclear receptor subfamily 1, group H, member 4 -2.12733
KIAA1549L KIAA1549-like -2.12466
ATRNL1 attractin-like 1 -2.12297
TSSK2 testis-specific serine kinase 2 -2.1195
PAPOLB poly(A) polymerase beta (testis specific) -2.1161
NPHP1 nephronophthisis 1 (juvenile) -2.11567
TGFB3 transforming growth factor, beta 3 -2.11316
STMN3 stathmin-like 3 -2.11191
UBQLN3 ubiquilin 3 -2.11141
DIAPH3 diaphanous-related formin 3 -2.10919
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.10635
SLC6A16 solute carrier family 6, member 16 -2.10549
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.10414
ACP2 acid phosphatase 2, lysosomal -2.1033
ZNF334 zinc finger protein 334 -2.10179
ZNF16 zinc finger protein 16 -2.09986
PROS1 protein S (alpha) -2.09977
ZNF549 zinc finger protein 549 -2.09767
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa -2.09745
C5AR2 complement component 5a receptor 2 -2.09205
JTB jumping translocation breakpoint -2.09202
ZNF471 zinc finger protein 471 -2.08539
PLD3 phospholipase D family, member 3 -2.084
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 -2.07897
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 -2.07895
MORC1 MORC family CW-type zinc finger 1 -2.07566
EIF5 eukaryotic translation initiation factor 5 -2.07413
EMC2 ER membrane protein complex subunit 2 -2.07285
MCF2 MCF.2 cell line derived transforming sequence -2.07255
EPPIN epididymal peptidase inhibitor -2.07214
TRPC3 transient receptor potential cation channel, subfamily C, member 3 -2.0721
BRDT bromodomain, testis-specific -2.06653
PGK2 phosphoglycerate kinase 2 -2.06553
RNF17 ring finger protein 17 -2.0652
PYCR3 pyrroline-5-carboxylate reductase 3 -2.064
DERA deoxyribose-phosphate aldolase (putative) -2.06112
RAVER2 ribonucleoprotein, PTB-binding 2 -2.05867
NPAP1 nuclear pore associated protein 1 -2.05851
MAPK10 mitogen-activated protein kinase 10 -2.05761
SPHK2 sphingosine kinase 2 -2.05719
SLCO5A1 solute carrier organic anion transporter family, member 5A1 -2.05549
MGAT4C MGAT4 family, member C -2.05257
HTN3 histatin 3 -2.0495
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25 -2.0444
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -2.04371
ZNF492 zinc finger protein 492 -2.04195
PPIAL4H peptidylprolyl isomerase A like 4H -2.04097
CCNB1 cyclin B1 -2.03963
SCG3 secretogranin III -2.03895
FZD8 frizzled class receptor 8 -2.03853
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11 -2.03378
CADPS2 Ca++-dependent secretion activator 2 -2.03193
TBC1D22B TBC1 domain family, member 22B -2.03038
GJA5 gap junction protein, alpha 5, 40kDa -2.02571
DHCR7 7-dehydrocholesterol reductase -2.02395
SOX1 SRY (sex determining region Y)-box 1 -2.02311
DCC DCC netrin 1 receptor -2.02235
KPNA5 karyopherin alpha 5 (importin alpha 6) -2.02149
ZNF221 zinc finger protein 221 -2.01978
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 -2.01102
ZNF835 zinc finger protein 835 -2.0029
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit -2.00285