| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 1,4-dimethyl-5h-pyrido[4,3-b]indol-3-amine acetate 1.29 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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59 genes differentially expressed following the CRCGN013_HEPG2_24H:I17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 10.0 |
| LCN2 | lipocalin 2 | 5.9256 |
| CNPY3 | canopy FGF signaling regulator 3 | 4.74048 |
| PPARG | peroxisome proliferator-activated receptor gamma | 3.90008 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 3.4825 |
| INPP1 | inositol polyphosphate-1-phosphatase | 3.40204 |
| CCNA1 | cyclin A1 | 3.25773 |
| IER3 | immediate early response 3 | 3.02414 |
| KIFBP | kinesin family binding protein | 2.98096 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 2.91123 |
| INTS3 | integrator complex subunit 3 | 2.75219 |
| ABHD6 | abhydrolase domain containing 6 | 2.60364 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 2.58423 |
| PARP2 | poly (ADP-ribose) polymerase 2 | 2.56662 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 2.55458 |
| TUBB6 | tubulin, beta 6 class V | 2.49437 |
| MAP7 | microtubule-associated protein 7 | 2.3214 |
| ACOT9 | acyl-CoA thioesterase 9 | 2.2828 |
| GPATCH8 | G patch domain containing 8 | 2.267 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit | 2.26131 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 2.2584 |
| TBP | TATA box binding protein | 2.24729 |
| SSBP2 | single-stranded DNA binding protein 2 | 2.22461 |
| DRAP1 | DR1-associated protein 1 (negative cofactor 2 alpha) | 2.18817 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 2.16493 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 2.16015 |
| SDHB | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | 2.13559 |
| SHOC2 | soc-2 suppressor of clear homolog (C. elegans) | 2.07319 |
| ADAT1 | adenosine deaminase, tRNA-specific 1 | 2.04787 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZW10 | zw10 kinetochore protein | -5.20868 |
| CCNB1 | cyclin B1 | -4.47596 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -4.38382 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -4.21075 |
| ADI1 | acireductone dioxygenase 1 | -3.68112 |
| CD320 | CD320 molecule | -3.64939 |
| TENT4A | terminal nucleotidyltransferase 4A | -3.57796 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -3.5036 |
| LDHD | lactate dehydrogenase D | -3.48236 |
| FGFR4 | fibroblast growth factor receptor 4 | -3.3586 |
| KDM3A | lysine (K)-specific demethylase 3A | -3.09233 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -3.04056 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -2.99321 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -2.93711 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -2.90664 |
| GDPD5 | glycerophosphodiester phosphodiesterase domain containing 5 | -2.70042 |
| EGF | epidermal growth factor | -2.69455 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -2.57435 |
| TLR4 | toll-like receptor 4 | -2.51427 |
| SLC35B1 | solute carrier family 35, member B1 | -2.50678 |
| ALDOC | aldolase C, fructose-bisphosphate | -2.48731 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | -2.41203 |
| ANKRD10 | ankyrin repeat domain 10 | -2.34222 |
| DERA | deoxyribose-phosphate aldolase (putative) | -2.32096 |
| PRCP | prolylcarboxypeptidase (angiotensinase C) | -2.21133 |
| FHL2 | four and a half LIM domains 2 | -2.13136 |
| DENND2D | DENN/MADD domain containing 2D | -2.06753 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -2.05942 |
| ICE1 | interactor of little elongation complex ELL subunit 1 | -2.05002 |
| CCNB2 | cyclin B2 | -2.00554 |
