CRCGN013_HEPG2_24H:I19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1h-1,2,3-benzotriazole 20.99 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

154 genes differentially expressed following the CRCGN013_HEPG2_24H:I19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 10.0
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 7.14637
FCHO1 FCH domain only 1 6.59645
CCL2 chemokine (C-C motif) ligand 2 5.68647
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 5.67099
HLA-DMA major histocompatibility complex, class II, DM alpha 5.51069
RPL39L ribosomal protein L39-like 4.80052
LAGE3 L antigen family, member 3 4.65334
BACE2 beta-site APP-cleaving enzyme 2 4.43508
CHN1 chimerin 1 4.09946
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.09782
HLA-DRA major histocompatibility complex, class II, DR alpha 4.08376
DYNLT3 dynein, light chain, Tctex-type 3 4.02204
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.94356
MAP7 microtubule-associated protein 7 3.90568
CEP57 centrosomal protein 57kDa 3.58754
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 3.58601
TIAM1 T-cell lymphoma invasion and metastasis 1 3.41315
SYNE2 spectrin repeat containing, nuclear envelope 2 3.28633
INSIG1 insulin induced gene 1 3.28374
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 3.2506
MYLK myosin light chain kinase 3.10729
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.07495
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.96773
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.94125
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.89514
NUP133 nucleoporin 133kDa 2.84819
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.83972
CHMP6 charged multivesicular body protein 6 2.81861
IFI44L interferon-induced protein 44-like 2.79912
RBM7 RNA binding motif protein 7 2.76238
RIGI RNA sensor RIG-I 2.66689
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 2.66251
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.65501
LCN2 lipocalin 2 2.63493
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 2.63201
TRIM6-TRIM34 TRIM6-TRIM34 readthrough 2.61867
ZNF589 zinc finger protein 589 2.59812
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.55778
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.55202
OXCT1 3-oxoacid CoA transferase 1 2.52034
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.45258
GATA2 GATA binding protein 2 2.43056
TRIM21 tripartite motif containing 21 2.42639
PLSCR1 phospholipid scramblase 1 2.42605
LIMD1 LIM domains containing 1 2.41825
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta 2.37084
LGALS13 lectin, galactoside-binding, soluble, 13 2.3503
RSAD2 radical S-adenosyl methionine domain containing 2 2.35011
DLX5 distal-less homeobox 5 2.34187
ZNF510 zinc finger protein 510 2.33236
SPATA31A3 SPATA31 subfamily A, member 3 2.33014
IFI6 interferon, alpha-inducible protein 6 2.30815
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 2.30786
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 2.30698
IL19 interleukin 19 2.29846
CYCS cytochrome c, somatic 2.25451
USH1C Usher syndrome 1C (autosomal recessive, severe) 2.24505
RTP4 receptor (chemosensory) transporter protein 4 2.23516
PARP1 poly (ADP-ribose) polymerase 1 2.23147
IFI44 interferon-induced protein 44 2.18593
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 2.16801
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 2.1533
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.15222
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.15031
OR2H1 olfactory receptor, family 2, subfamily H, member 1 2.14671
ATRIP ATR interacting protein 2.14451
FGF1 fibroblast growth factor 1 (acidic) 2.14364
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 2.13058
MSI1 musashi RNA-binding protein 1 2.11856
MED17 mediator complex subunit 17 2.11767
EHMT1 euchromatic histone-lysine N-methyltransferase 1 2.11326
ONECUT2 one cut homeobox 2 2.08376
TPD52L2 tumor protein D52-like 2 2.0827
TMEM9B TMEM9 domain family, member B 2.08138
SAMD9 sterile alpha motif domain containing 9 2.07737
OXT oxytocin/neurophysin I prepropeptide 2.07285
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 2.07062
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.06425
PPIL6 peptidylprolyl isomerase (cyclophilin)-like 6 2.06409
IFI35 interferon-induced protein 35 2.06227
PEX11A peroxisomal biogenesis factor 11 alpha 2.06188
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 2.06116
NTM neurotrimin 2.05779
MIS18A MIS18 kinetochore protein A 2.05572
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 2.0555
SIRT3 sirtuin 3 2.0537
IFITM1 interferon induced transmembrane protein 1 2.05173
TFCP2L1 transcription factor CP2-like 1 2.04856
AOC1 amine oxidase, copper containing 1 2.0457
ACAN aggrecan 2.04271
INSL6 insulin-like 6 2.04182
NPY4R2 neuropeptide Y receptor Y4-2 2.04174
OASL 2'-5'-oligoadenylate synthetase-like 2.02926
RBMS3 RNA binding motif, single stranded interacting protein 3 2.02903
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 2.02878
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 2.02367
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 2.02223
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 2.01757
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 2.01506
GML glycosylphosphatidylinositol anchored molecule like 2.00643
OR7A17 olfactory receptor, family 7, subfamily A, member 17 2.00547

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -7.03806
HMG20B high mobility group 20B -5.21464
NGRN neugrin, neurite outgrowth associated -5.16235
CCDC86 coiled-coil domain containing 86 -4.36356
NUP85 nucleoporin 85kDa -4.3047
TNIP1 TNFAIP3 interacting protein 1 -4.01084
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.00639
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.91821
CAB39 calcium binding protein 39 -3.88317
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.66812
COG2 component of oligomeric golgi complex 2 -3.61469
CDC20 cell division cycle 20 -3.45706
THAP11 THAP domain containing 11 -3.2856
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.27429
RGS2 regulator of G-protein signaling 2 -3.268
COG4 component of oligomeric golgi complex 4 -3.10199
YME1L1 YME1-like 1 ATPase -3.04742
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.96244
RFC2 replication factor C (activator 1) 2, 40kDa -2.80578
TEX10 testis expressed 10 -2.75087
CHIC2 cysteine-rich hydrophobic domain 2 -2.60749
SIRT7 sirtuin 7 -2.44493
MUC6 mucin 6, oligomeric mucus/gel-forming -2.37193
MRPS7 mitochondrial ribosomal protein S7 -2.37031
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.34586
TSPAN14 tetraspanin 14 -2.32022
UBE2O ubiquitin-conjugating enzyme E2O -2.31472
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.29173
CHMP4B charged multivesicular body protein 4B -2.27777
WDR7 WD repeat domain 7 -2.27372
LDHD lactate dehydrogenase D -2.26397
FKBP14 FK506 binding protein 14, 22 kDa -2.25462
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 -2.24455
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.24251
SLC35F2 solute carrier family 35, member F2 -2.21423
CLDN1 claudin 1 -2.16877
HGS hepatocyte growth factor-regulated tyrosine kinase substrate -2.1638
KIF14 kinesin family member 14 -2.16345
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) -2.15072
CCL20 chemokine (C-C motif) ligand 20 -2.12057
EIF3B eukaryotic translation initiation factor 3, subunit B -2.11998
LRRC47 leucine rich repeat containing 47 -2.10505
UBE3C ubiquitin protein ligase E3C -2.09812
CRTAP cartilage associated protein -2.08241
SPATS2 spermatogenesis associated, serine-rich 2 -2.08114
H2AB2 H2A.B variant histone 2 -2.07756
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.06059
OSTM1 osteopetrosis associated transmembrane protein 1 -2.05485
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B -2.0417
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.04116
HSPA4L heat shock 70kDa protein 4-like -2.03459
SLC4A2 solute carrier family 4 (anion exchanger), member 2 -2.01205