CRCGN013_HEPG2_24H:I22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1h-1,2,3-benzotriazole 2.62 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

29 genes differentially expressed following the CRCGN013_HEPG2_24H:I22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GSTZ1 glutathione S-transferase zeta 1 4.78198
SQOR sulfide quinone oxidoreductase 4.67385
CEP57 centrosomal protein 57kDa 4.12303
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.65271
SNAP25 synaptosomal-associated protein, 25kDa 3.10709
GPER1 G protein-coupled estrogen receptor 1 3.08318
VGLL4 vestigial-like family member 4 2.8373
CYB561 cytochrome b561 2.41526
TBP TATA box binding protein 2.19035
CHN1 chimerin 1 2.18286
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 2.12978
HSPA1A heat shock 70kDa protein 1A 2.08965

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.82337
PCNA proliferating cell nuclear antigen -5.13168
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.60077
TRIB3 tribbles pseudokinase 3 -4.52648
GNAS GNAS complex locus -4.21111
FGFR4 fibroblast growth factor receptor 4 -3.93945
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.56104
GDF15 growth differentiation factor 15 -3.35993
MAPK13 mitogen-activated protein kinase 13 -3.07018
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.0358
CCNB2 cyclin B2 -2.90899
MACF1 microtubule-actin crosslinking factor 1 -2.87153
NGRN neugrin, neurite outgrowth associated -2.86637
APOE apolipoprotein E -2.17479
HLA-DMA major histocompatibility complex, class II, DM alpha -2.13207
PRPF4 pre-mRNA processing factor 4 -2.1015
RGS2 regulator of G-protein signaling 2 -2.03778