CRCGN013_HEPG2_24H:I23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1h-1,2,3-benzotriazole 1.31 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

76 genes differentially expressed following the CRCGN013_HEPG2_24H:I23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 7.724
CBR3 carbonyl reductase 3 7.59802
GPER1 G protein-coupled estrogen receptor 1 6.91696
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 6.22313
C2CD2 C2 calcium-dependent domain containing 2 5.61323
MAMLD1 mastermind-like domain containing 1 5.37084
NOTCH1 notch 1 5.18437
STAP2 signal transducing adaptor family member 2 5.14496
ADRB2 adrenoceptor beta 2, surface 5.08966
FOXO4 forkhead box O4 5.00326
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.71084
CIAO3 cytosolic iron-sulfur assembly component 3 4.69795
PRR15L proline rich 15-like 4.55494
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.52395
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.15125
ATP11B ATPase, class VI, type 11B 3.99479
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.93411
MYLK myosin light chain kinase 3.25221
CHEK2 checkpoint kinase 2 3.117
TIAM1 T-cell lymphoma invasion and metastasis 1 3.09097
CCL2 chemokine (C-C motif) ligand 2 2.88347
TXNL4B thioredoxin-like 4B 2.80709
POF1B premature ovarian failure, 1B 2.75397
ARMC6 armadillo repeat containing 6 2.55788
TREM1 triggering receptor expressed on myeloid cells 1 2.46172
CHN1 chimerin 1 2.43801
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa 2.41336
LMO7 LIM domain 7 2.39682
ST20-MTHFS ST20-MTHFS readthrough 2.36308
PHEX phosphate regulating endopeptidase homolog, X-linked 2.31122
GAA glucosidase, alpha; acid 2.28045
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.27518
ZNG1A Zn regulated GTPase metalloprotein activator 1A 2.27328
NGF nerve growth factor (beta polypeptide) 2.26626
MPZL2 myelin protein zero-like 2 2.26191
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.2543
CNPY4 canopy FGF signaling regulator 4 2.24237
BEST1 bestrophin 1 2.21704
SNCG synuclein, gamma (breast cancer-specific protein 1) 2.21667
KIF20A kinesin family member 20A 2.21294
FAM110D family with sequence similarity 110, member D 2.19406
STEAP4 STEAP family member 4 2.16723
CCN6 cellular communication network factor 6 2.16523
KLHL9 kelch-like family member 9 2.15011
LPAR2 lysophosphatidic acid receptor 2 2.11643
VSTM4 V-set and transmembrane domain containing 4 2.10393
ANO1 anoctamin 1, calcium activated chloride channel 2.10204
SCN1A sodium channel, voltage gated, type I alpha subunit 2.07145
STXBP1 syntaxin binding protein 1 2.05435
TMEM243 transmembrane protein 243, mitochondrial 2.05059
ZNF646 zinc finger protein 646 2.02103

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -7.26823
CDC20 cell division cycle 20 -4.81102
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.51234
FABP5 fatty acid binding protein 5 (psoriasis-associated) -4.0901
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.08267
TM9SF3 transmembrane 9 superfamily member 3 -3.65929
GNAS GNAS complex locus -3.52259
UBE3C ubiquitin protein ligase E3C -2.98842
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.8565
RGS2 regulator of G-protein signaling 2 -2.71449
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.69708
DNM1L dynamin 1-like -2.48776
TRIB3 tribbles pseudokinase 3 -2.44977
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.4282
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.38425
ITGB1BP1 integrin beta 1 binding protein 1 -2.26738
THOC7 THO complex 7 -2.24813
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis) -2.24435
TBC1D10C TBC1 domain family, member 10C -2.17595
CHIC2 cysteine-rich hydrophobic domain 2 -2.10596
NRIP1 nuclear receptor interacting protein 1 -2.07374
HELZ helicase with zinc finger -2.06167
GLOD4 glyoxalase domain containing 4 -2.05859
NGRN neugrin, neurite outgrowth associated -2.02217
FAM3C family with sequence similarity 3, member C -2.00887