| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 3,3'-dimethoxybenzidine.2hcl 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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56 genes differentially expressed following the CRCGN013_HEPG2_24H:J01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CHMP6 | charged multivesicular body protein 6 | 6.56763 |
| CHN1 | chimerin 1 | 5.25363 |
| SSBP2 | single-stranded DNA binding protein 2 | 4.68303 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 3.62301 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 3.52301 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 3.49594 |
| MSRA | methionine sulfoxide reductase A | 3.43765 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 3.24375 |
| TRIB3 | tribbles pseudokinase 3 | 3.21639 |
| ADRB2 | adrenoceptor beta 2, surface | 3.13534 |
| RRAGA | Ras-related GTP binding A | 3.11008 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 3.06896 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.93139 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 2.89381 |
| CCL2 | chemokine (C-C motif) ligand 2 | 2.73872 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 2.51481 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 2.39862 |
| DNMT3A | DNA (cytosine-5-)-methyltransferase 3 alpha | 2.38686 |
| SNX7 | sorting nexin 7 | 2.26811 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 2.24223 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 2.18894 |
| SFTPB | surfactant protein B | 2.17324 |
| DDIT4 | DNA-damage-inducible transcript 4 | 2.1539 |
| MYLK | myosin light chain kinase | 2.15128 |
| TPD52L2 | tumor protein D52-like 2 | 2.11822 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 2.0442 |
| MKNK1 | MAP kinase interacting serine/threonine kinase 1 | 2.02668 |
| UGDH | UDP-glucose 6-dehydrogenase | 2.01586 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 2.01424 |
| SKIC2 | SKI2 subunit of superkiller complex | 2.0031 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LDHD | lactate dehydrogenase D | -10.0 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -5.66074 |
| CDC20 | cell division cycle 20 | -4.40071 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -3.91805 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -3.6964 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -3.4838 |
| ZNF274 | zinc finger protein 274 | -3.32232 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.18063 |
| CD320 | CD320 molecule | -3.16924 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -3.13001 |
| ADI1 | acireductone dioxygenase 1 | -2.90171 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -2.83829 |
| PCNA | proliferating cell nuclear antigen | -2.63974 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -2.51006 |
| CRYZ | crystallin, zeta (quinone reductase) | -2.50095 |
| RGS2 | regulator of G-protein signaling 2 | -2.34462 |
| HLTF | helicase-like transcription factor | -2.20426 |
| TCTN1 | tectonic family member 1 | -2.20032 |
| GNAS | GNAS complex locus | -2.17774 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -2.13113 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -2.10334 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -2.06919 |
| TNK1 | tyrosine kinase, non-receptor, 1 | -2.06566 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.02913 |
| ICAM3 | intercellular adhesion molecule 3 | -2.00576 |
| PRSS22 | protease, serine, 22 | -2.00527 |
