CRCGN013_HEPG2_24H:J02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dimethoxybenzidine.2hcl 20.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

58 genes differentially expressed following the CRCGN013_HEPG2_24H:J02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SSBP2 single-stranded DNA binding protein 2 4.93983
LCN2 lipocalin 2 4.34505
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.06139
MYLK myosin light chain kinase 4.0609
CHMP6 charged multivesicular body protein 6 3.8473
CCNA1 cyclin A1 3.7047
EPHB2 EPH receptor B2 3.5681
LAGE3 L antigen family, member 3 3.56221
CXCR4 chemokine (C-X-C motif) receptor 4 3.51467
GPER1 G protein-coupled estrogen receptor 1 3.51298
CIAO3 cytosolic iron-sulfur assembly component 3 3.4536
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.42269
SFTPB surfactant protein B 3.39065
ADRB2 adrenoceptor beta 2, surface 3.38333
NOTCH1 notch 1 3.3406
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.17755
CBR3 carbonyl reductase 3 3.14118
TCTA T-cell leukemia translocation altered 2.54562
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.46611
LHX1 LIM homeobox 1 2.45148
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.32765
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.26769
MECR mitochondrial trans-2-enoyl-CoA reductase 2.24283
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.23151
CYCS cytochrome c, somatic 2.21486
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 2.17949
RPL39L ribosomal protein L39-like 2.17482
CEP57 centrosomal protein 57kDa 2.16261
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.16114
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.12339
TREM1 triggering receptor expressed on myeloid cells 1 2.1048
DHDDS dehydrodolichyl diphosphate synthase 2.03311
LRP10 low density lipoprotein receptor-related protein 10 2.02371
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.01385
MMP1 matrix metallopeptidase 1 2.0026

decreased expression

Symbol Name Standardized Value
TLCD3A TLC domain containing 3A -6.65646
LDHD lactate dehydrogenase D -6.42057
C2CD5 C2 calcium-dependent domain containing 5 -4.38213
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.32877
GNAS GNAS complex locus -3.99116
CCP110 centriolar coiled coil protein 110kDa -3.9107
NCK1 NCK adaptor protein 1 -3.89326
CCNB2 cyclin B2 -3.44557
ISOC1 isochorismatase domain containing 1 -3.06279
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -2.71634
SLC35F2 solute carrier family 35, member F2 -2.67721
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.66314
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -2.65966
UGDH UDP-glucose 6-dehydrogenase -2.42772
EDN1 endothelin 1 -2.38521
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.31199
FBXL12 F-box and leucine-rich repeat protein 12 -2.29154
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.25825
TMEM109 transmembrane protein 109 -2.17714
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.17038
GLOD4 glyoxalase domain containing 4 -2.11886
DOCK1 dedicator of cytokinesis 1 -2.05605
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.0079