CRCGN013_HEPG2_24H:J03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dimethoxybenzidine.2hcl 10.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

94 genes differentially expressed following the CRCGN013_HEPG2_24H:J03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 8.56383
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.6448
CIAO3 cytosolic iron-sulfur assembly component 3 4.89726
PMM2 phosphomannomutase 2 4.76439
CXCL2 chemokine (C-X-C motif) ligand 2 4.47032
JADE2 jade family PHD finger 2 4.43916
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.17661
CDC45 cell division cycle 45 3.98974
HLA-DMA major histocompatibility complex, class II, DM alpha 3.82087
EVL Enah/Vasp-like 3.78781
LCN2 lipocalin 2 3.7377
BTK Bruton agammaglobulinemia tyrosine kinase 3.66566
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.63455
ADGRE5 adhesion G protein-coupled receptor E5 3.54385
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.48899
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 3.31302
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 3.10643
EGF epidermal growth factor 3.08512
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.88291
NFIL3 nuclear factor, interleukin 3 regulated 2.73403
ANO1 anoctamin 1, calcium activated chloride channel 2.65387
CCL2 chemokine (C-C motif) ligand 2 2.52939
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.51417
RIGI RNA sensor RIG-I 2.5059
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.45752
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.43814
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.43331
PRR15L proline rich 15-like 2.42875
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.41116
IFI44 interferon-induced protein 44 2.39243
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 2.3838
MX1 MX dynamin-like GTPase 1 2.38219
DGCR6L DiGeorge syndrome critical region gene 6-like 2.37935
IFI44L interferon-induced protein 44-like 2.36817
TESK1 testis-specific kinase 1 2.3511
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.3478
SH3D19 SH3 domain containing 19 2.2831
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.24362
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.24057
TBC1D31 TBC1 domain family, member 31 2.20725
RTP4 receptor (chemosensory) transporter protein 4 2.19102
ECD ecdysoneless homolog (Drosophila) 2.18521
HHEX hematopoietically expressed homeobox 2.17565
CD180 CD180 molecule 2.15997
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.11683
ZMYM1 zinc finger, MYM-type 1 2.10297
JAK2 Janus kinase 2 2.08772
RMI1 RecQ mediated genome instability 1 2.0596
MX2 MX dynamin-like GTPase 2 2.04823
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 2.04722
IL22RA1 interleukin 22 receptor, alpha 1 2.04155
CXCL3 chemokine (C-X-C motif) ligand 3 2.04016
NFE2L3 nuclear factor, erythroid 2-like 3 2.03496
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2.02772
RSAD2 radical S-adenosyl methionine domain containing 2 2.01471
OXCT1 3-oxoacid CoA transferase 1 2.01442
FMO1 flavin containing monooxygenase 1 2.00118
ZNF318 zinc finger protein 318 2.00055

decreased expression

Symbol Name Standardized Value
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -6.51461
SLC35F2 solute carrier family 35, member F2 -6.45227
GNAS GNAS complex locus -6.30727
CAB39 calcium binding protein 39 -5.15797
NGRN neugrin, neurite outgrowth associated -4.79807
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.78899
CCNB2 cyclin B2 -3.70908
CDC25B cell division cycle 25B -3.69362
RGS2 regulator of G-protein signaling 2 -3.68578
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.36084
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.32709
LDHD lactate dehydrogenase D -3.31418
FBXL12 F-box and leucine-rich repeat protein 12 -3.27106
HEATR1 HEAT repeat containing 1 -3.26207
AURKB aurora kinase B -3.20318
SCCPDH saccharopine dehydrogenase (putative) -3.116
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.85987
CRELD2 cysteine-rich with EGF-like domains 2 -2.81626
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.54839
TCTN1 tectonic family member 1 -2.4316
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.41684
AQP3 aquaporin 3 (Gill blood group) -2.34504
CRTAP cartilage associated protein -2.25091
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.22567
NPTN neuroplastin -2.20891
CUEDC2 CUE domain containing 2 -2.16589
RNF115 ring finger protein 115 -2.15675
FOXF1 forkhead box F1 -2.14277
MFAP4 microfibrillar-associated protein 4 -2.12678
TM2D3 TM2 domain containing 3 -2.08023
LYPLA1 lysophospholipase I -2.07925
ILK integrin-linked kinase -2.06308
RNF167 ring finger protein 167 -2.05526
USP6NL USP6 N-terminal like -2.04308
CD177 CD177 molecule -2.00454
LIMS2 LIM and senescent cell antigen-like domains 2 -2.00039