CRCGN013_HEPG2_24H:J04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dimethoxybenzidine.2hcl 5.03 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

71 genes differentially expressed following the CRCGN013_HEPG2_24H:J04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 4.68718
JADE2 jade family PHD finger 2 4.2382
STIMATE STIM activating enhancer 4.1121
USP6NL USP6 N-terminal like 3.69194
KIFBP kinesin family binding protein 3.67308
LCN2 lipocalin 2 3.53395
NOSIP nitric oxide synthase interacting protein 3.52038
MICALL1 MICAL-like 1 3.36871
ADAT1 adenosine deaminase, tRNA-specific 1 3.05506
NOTCH1 notch 1 3.01459
MROH9 maestro heat-like repeat family member 9 2.56209
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.53612
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.50818
MCUR1 mitochondrial calcium uniporter regulator 1 2.46086
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.44793
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 2.40599
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.38096
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.31438
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 2.30222
NPHP1 nephronophthisis 1 (juvenile) 2.29716
EVL Enah/Vasp-like 2.25772
SCN11A sodium channel, voltage gated, type XI alpha subunit 2.25126
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.25041
PLA2R1 phospholipase A2 receptor 1, 180kDa 2.23247
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.21941
ASCL2 achaete-scute family bHLH transcription factor 2 2.19707
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.18777
ZNF589 zinc finger protein 589 2.17818
SPRYD7 SPRY domain containing 7 2.1423
ZNF682 zinc finger protein 682 2.13187
RFPL1 ret finger protein-like 1 2.13164
RNF170 ring finger protein 170 2.1245
CCDC144A coiled-coil domain containing 144A 2.12372
MAGEB4 melanoma antigen family B4 2.11299
KRT12 keratin 12, type I 2.09597
OR1E1 olfactory receptor, family 1, subfamily E, member 1 2.08618
SLC49A3 solute carrier family 49 member 3 2.08466
EXOC6B exocyst complex component 6B 2.0706
KRT20 keratin 20, type I 2.06734
OR2W1 olfactory receptor, family 2, subfamily W, member 1 2.06417
ZBP1 Z-DNA binding protein 1 2.0607
NIPSNAP3B nipsnap homolog 3B (C. elegans) 2.05869
MMP27 matrix metallopeptidase 27 2.05363
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 2.05325
CTAGE1 cutaneous T-cell lymphoma-associated antigen 1 2.04654
GLRA1 glycine receptor, alpha 1 2.04537
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10 2.02227
NPBWR2 neuropeptides B/W receptor 2 2.02087
ZBTB33 zinc finger and BTB domain containing 33 2.01486
RAVER2 ribonucleoprotein, PTB-binding 2 2.00469
ZNF674 zinc finger protein 674 2.00467
ACOXL acyl-CoA oxidase-like 2.00025

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.5513
GTPBP8 GTP-binding protein 8 (putative) -5.11703
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -5.11025
COG7 component of oligomeric golgi complex 7 -5.10861
TRIB3 tribbles pseudokinase 3 -4.78964
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.54992
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.35632
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.34791
MAP7 microtubule-associated protein 7 -3.02717
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.91357
OXA1L oxidase (cytochrome c) assembly 1-like -2.77271
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.72921
LOC124907782 dual specificity protein phosphatase 22 -2.62187
TLCD3A TLC domain containing 3A -2.56057
CCNB2 cyclin B2 -2.47463
TUBGCP4 tubulin, gamma complex associated protein 4 -2.27296
BBS4 Bardet-Biedl syndrome 4 -2.14986
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.09896
SFXN1 sideroflexin 1 -2.04059