CRCGN013_HEPG2_24H:J06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dimethoxybenzidine.2hcl 1.26 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN013_HEPG2_24H:J06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHN1 chimerin 1 6.65152
EPHB2 EPH receptor B2 5.03289
LCN2 lipocalin 2 5.0
RPL39L ribosomal protein L39-like 4.92809
ADRB2 adrenoceptor beta 2, surface 4.8274
SNAP25 synaptosomal-associated protein, 25kDa 4.72689
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.49308
FZD7 frizzled class receptor 7 4.3942
ADAM10 ADAM metallopeptidase domain 10 4.10531
PLSCR1 phospholipid scramblase 1 3.86685
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.56094
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.42603
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.42486
GARRE1 granule associated Rac and RHOG effector 1 3.42152
CEP57 centrosomal protein 57kDa 3.34151
CBR3 carbonyl reductase 3 3.30246
EPHA3 EPH receptor A3 3.17536
TGFB3 transforming growth factor, beta 3 3.1159
PLS1 plastin 1 2.7867
VGLL4 vestigial-like family member 4 2.70316
JADE2 jade family PHD finger 2 2.5125
IFITM1 interferon induced transmembrane protein 1 2.47014
DIPK1A divergent protein kinase domain 1A 2.43286
PMM2 phosphomannomutase 2 2.41446
STK10 serine/threonine kinase 10 2.411
NPDC1 neural proliferation, differentiation and control, 1 2.36422
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa 2.36007
CHODL chondrolectin 2.30366
TREM1 triggering receptor expressed on myeloid cells 1 2.27227
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.20792
DHDDS dehydrodolichyl diphosphate synthase 2.1758
CASP1 caspase 1, apoptosis-related cysteine peptidase 2.15134
ANO10 anoctamin 10 2.11197
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 2.09942
DCN decorin 2.06166
LINC02762 long intergenic non-protein coding RNA 2762 2.05183
HLA-DRA major histocompatibility complex, class II, DR alpha 2.01865

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -5.4034
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.70312
GNAS GNAS complex locus -3.65288
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.29649
FASTKD5 FAST kinase domains 5 -2.78678
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.65461
DERA deoxyribose-phosphate aldolase (putative) -2.63389
CAB39 calcium binding protein 39 -2.56264
LDHD lactate dehydrogenase D -2.54871
MVP major vault protein -2.49614
SPAG4 sperm associated antigen 4 -2.48804
NRIP1 nuclear receptor interacting protein 1 -2.45319
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -2.40491
RGS2 regulator of G-protein signaling 2 -2.3137
EPS8 epidermal growth factor receptor pathway substrate 8 -2.20781
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.20354
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.15486
GSTA1 glutathione S-transferase alpha 1 -2.1124
MST1R macrophage stimulating 1 receptor -2.10406
SH2D4A SH2 domain containing 4A -2.08861
RAB5C RAB5C, member RAS oncogene family -2.08318
PER1 period circadian clock 1 -2.00337