CRCGN013_HEPG2_24H:J08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n,n-dimethyl-n'-[3-(trifluoromethyl)phenyl]urea 10.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

105 genes differentially expressed following the CRCGN013_HEPG2_24H:J08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPP1R13B protein phosphatase 1, regulatory subunit 13B 5.63271
MYLK myosin light chain kinase 4.9726
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.7762
LCN2 lipocalin 2 4.67178
STK10 serine/threonine kinase 10 4.60794
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.55589
ADGRE5 adhesion G protein-coupled receptor E5 4.53536
RXYLT1 ribitol xylosyltransferase 1 3.75294
CEP57 centrosomal protein 57kDa 3.63498
FZD7 frizzled class receptor 7 3.44782
PFKL phosphofructokinase, liver 3.23754
BAMBI BMP and activin membrane-bound inhibitor 3.14125
TESK1 testis-specific kinase 1 3.09198
NOSIP nitric oxide synthase interacting protein 3.00054
JADE2 jade family PHD finger 2 2.9642
TMEM109 transmembrane protein 109 2.83756
PLSCR3 phospholipid scramblase 3 2.78488
CYCS cytochrome c, somatic 2.60694
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.53157
KIF18A kinesin family member 18A 2.47045
HIKESHI heat shock protein nuclear import factor hikeshi 2.43127
MOGAT1 monoacylglycerol O-acyltransferase 1 2.4235
SKA1 spindle and kinetochore associated complex subunit 1 2.40429
SPC25 SPC25, NDC80 kinetochore complex component 2.34779
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.33743
LRP10 low density lipoprotein receptor-related protein 10 2.31332
LOC102724560 cystathionine beta-synthase 2.25904
HLA-DRA major histocompatibility complex, class II, DR alpha 2.25693
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 2.24034
UST uronyl-2-sulfotransferase 2.2357
CNPY3 canopy FGF signaling regulator 3 2.18658
ZNF200 zinc finger protein 200 2.18427
YEATS2 YEATS domain containing 2 2.1671
TBP TATA box binding protein 2.15771
SATB1 SATB homeobox 1 2.15729
MATN2 matrilin 2 2.11473
YEATS4 YEATS domain containing 4 2.11142
ANAPC10 anaphase promoting complex subunit 10 2.08443
IL1B interleukin 1, beta 2.07681
CENPQ centromere protein Q 2.06681
EHD4 EH-domain containing 4 2.05526
NEIL3 nei endonuclease VIII-like 3 (E. coli) 2.05298
SNAI2 snail family zinc finger 2 2.0245
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2 2.01536
CRIPT cysteine-rich PDZ-binding protein 2.01288
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa 2.01248
ZNF227 zinc finger protein 227 2.00823

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -7.48046
GNAS GNAS complex locus -7.00519
PCNA proliferating cell nuclear antigen -5.78857
CDC20 cell division cycle 20 -5.58476
CHMP4B charged multivesicular body protein 4B -5.22348
ZNF586 zinc finger protein 586 -4.68208
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.59846
TRAPPC3 trafficking protein particle complex 3 -4.57619
YME1L1 YME1-like 1 ATPase -4.33664
LDHD lactate dehydrogenase D -4.24613
TLCD3A TLC domain containing 3A -4.13871
MAPK13 mitogen-activated protein kinase 13 -3.85911
VDAC1 voltage-dependent anion channel 1 -3.72763
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.57524
MAP7 microtubule-associated protein 7 -3.48001
OXA1L oxidase (cytochrome c) assembly 1-like -3.41879
SLC35F2 solute carrier family 35, member F2 -3.36141
HEATR1 HEAT repeat containing 1 -3.02498
TXNDC9 thioredoxin domain containing 9 -3.0245
CCP110 centriolar coiled coil protein 110kDa -3.01255
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.93544
UBE3C ubiquitin protein ligase E3C -2.9163
GDF15 growth differentiation factor 15 -2.89227
SQSTM1 sequestosome 1 -2.61725
CAB39 calcium binding protein 39 -2.58369
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.56444
TXNRD1 thioredoxin reductase 1 -2.47912
DUSP13A dual specificity phosphatase 13A -2.39634
TJP2 tight junction protein 2 -2.32543
KLK2 kallikrein-related peptidase 2 -2.31695
PYGL phosphorylase, glycogen, liver -2.31617
RPL34 ribosomal protein L34 -2.30518
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.30493
CAV3 caveolin 3 -2.2912
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) -2.28113
S100A6 S100 calcium binding protein A6 -2.25841
FAM222B family with sequence similarity 222, member B -2.24045
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.23428
ETFB electron-transfer-flavoprotein, beta polypeptide -2.22865
CD177 CD177 molecule -2.2125
BLTP2 bridge-like lipid transfer protein family member 2 -2.20479
ACTN3 actinin, alpha 3 (gene/pseudogene) -2.19256
DNALI1 dynein, axonemal, light intermediate chain 1 -2.16058
NALF1 NALCN channel auxiliary factor 1 -2.15977
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -2.11242
LTF lactotransferrin -2.10859
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) -2.10195
STEAP4 STEAP family member 4 -2.10028
LDB3 LIM domain binding 3 -2.09408
ST14 suppression of tumorigenicity 14 (colon carcinoma) -2.09353
TGM4 transglutaminase 4 -2.08605
SYN1 synapsin I -2.05064
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -2.03651
TUBA1C tubulin, alpha 1c -2.03408
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 -2.03369
SCN10A sodium channel, voltage gated, type X alpha subunit -2.03223
IFNA13 interferon, alpha 13 -2.02541
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 -2.00624