CRCGN013_HEPG2_24H:J09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n,n-dimethyl-n'-[3-(trifluoromethyl)phenyl]urea 5.02 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

35 genes differentially expressed following the CRCGN013_HEPG2_24H:J09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 6.20679
GFOD1 glucose-fructose oxidoreductase domain containing 1 4.59892
EGF epidermal growth factor 3.95434
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.60488
TBP TATA box binding protein 3.49651
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.06053
UBQLN2 ubiquilin 2 3.04158
PRR15L proline rich 15-like 2.95727
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.74911
CDPF1 cysteine-rich, DPF motif domain containing 1 2.74263
BAMBI BMP and activin membrane-bound inhibitor 2.73439
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.68467
CHN1 chimerin 1 2.62763
PEX11A peroxisomal biogenesis factor 11 alpha 2.4359
CYB561 cytochrome b561 2.39034
ADAT1 adenosine deaminase, tRNA-specific 1 2.29594
GSTZ1 glutathione S-transferase zeta 1 2.21893
PLSCR3 phospholipid scramblase 3 2.21807

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.18704
PCNA proliferating cell nuclear antigen -5.27611
NT5DC2 5'-nucleotidase domain containing 2 -4.62032
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.49898
RFC2 replication factor C (activator 1) 2, 40kDa -4.48017
CCNB1 cyclin B1 -4.39712
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.33667
OXA1L oxidase (cytochrome c) assembly 1-like -3.78444
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.70388
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.3204
TLCD3A TLC domain containing 3A -3.25138
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.81712
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.42313
TLR4 toll-like receptor 4 -2.25225
WASHC4 WASH complex subunit 4 -2.0554
TXNDC9 thioredoxin domain containing 9 -2.04164
IL19 interleukin 19 -2.01885