CRCGN013_HEPG2_24H:J10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n,n-dimethyl-n'-[3-(trifluoromethyl)phenyl]urea 2.51 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

53 genes differentially expressed following the CRCGN013_HEPG2_24H:J10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADRB2 adrenoceptor beta 2, surface 5.51725
MCOLN1 mucolipin 1 5.48979
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 5.3543
UBQLN2 ubiquilin 2 4.71551
CIAO3 cytosolic iron-sulfur assembly component 3 4.59496
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 4.5892
SQOR sulfide quinone oxidoreductase 4.37516
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.00089
EVL Enah/Vasp-like 3.94021
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.85849
CARMIL1 capping protein regulator and myosin 1 linker 1 3.85429
FZD7 frizzled class receptor 7 3.8396
LOC122526780 uncharacterized LOC122526780 3.82768
KLHL21 kelch-like family member 21 3.72851
ABHD6 abhydrolase domain containing 6 3.7202
PPARG peroxisome proliferator-activated receptor gamma 3.71797
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.70825
SSBP2 single-stranded DNA binding protein 2 3.41001
RPP38 ribonuclease P/MRP 38kDa subunit 3.36328
LCN2 lipocalin 2 3.35668
ADAT1 adenosine deaminase, tRNA-specific 1 3.04722
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.7917
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.76001
RRAGA Ras-related GTP binding A 2.64556
TIAM1 T-cell lymphoma invasion and metastasis 1 2.62981
ZNF589 zinc finger protein 589 2.3178
SNX7 sorting nexin 7 2.2218
CRTAP cartilage associated protein 2.1947
NEK11 NIMA-related kinase 11 2.16732
SMYD5 SMYD family member 5 2.11418
NR1H3 nuclear receptor subfamily 1, group H, member 3 2.06967
EPN2 epsin 2 2.06199
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 2.03746

decreased expression

Symbol Name Standardized Value
TUBB6 tubulin, beta 6 class V -5.42058
CCNB2 cyclin B2 -4.8004
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -4.78946
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.08382
LDHD lactate dehydrogenase D -4.07491
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.00059
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.93671
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.75286
CCNB1 cyclin B1 -3.7495
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.04768
MAPK13 mitogen-activated protein kinase 13 -2.8872
TRAPPC6A trafficking protein particle complex 6A -2.75678
OXA1L oxidase (cytochrome c) assembly 1-like -2.7417
SNX11 sorting nexin 11 -2.51076
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.38214
RFC2 replication factor C (activator 1) 2, 40kDa -2.19265
ZMIZ1 zinc finger, MIZ-type containing 1 -2.15887
PUM1 pumilio RNA-binding family member 1 -2.10388
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -2.03576
HLX H2.0-like homeobox -2.01003