CRCGN013_HEPG2_24H:J12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n,n-dimethyl-n'-[3-(trifluoromethyl)phenyl]urea 0.63 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN013_HEPG2_24H:J12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RPP38 ribonuclease P/MRP 38kDa subunit 3.64463
CXCL2 chemokine (C-X-C motif) ligand 2 3.57526
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.53663
NOTCH1 notch 1 3.3176
UBQLN2 ubiquilin 2 3.21044
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 3.14856
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.53409
HSPA14 heat shock 70kDa protein 14 2.51876
CDPF1 cysteine-rich, DPF motif domain containing 1 2.51619
TCEA2 transcription elongation factor A (SII), 2 2.48452
KDM5A lysine (K)-specific demethylase 5A 2.45783
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.32532
EGF epidermal growth factor 2.21993
BAX BCL2-associated X protein 2.20508
EVL Enah/Vasp-like 2.18686
CHN1 chimerin 1 2.15513
GARRE1 granule associated Rac and RHOG effector 1 2.14677
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.13924
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.02242

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.16391
PCNA proliferating cell nuclear antigen -5.36039
ACOT9 acyl-CoA thioesterase 9 -3.93868
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.77835
FASTKD5 FAST kinase domains 5 -3.73465
ZNF586 zinc finger protein 586 -3.61178
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.36779
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.3401
PLK1 polo-like kinase 1 -3.31352
DNM1L dynamin 1-like -3.25521
BLCAP bladder cancer associated protein -3.17854
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.15986
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.01278
SLC35F2 solute carrier family 35, member F2 -2.57335
GRN granulin -2.55258
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.4965
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.45521
TXNRD1 thioredoxin reductase 1 -2.27406
GNAS GNAS complex locus -2.24907
NGRN neugrin, neurite outgrowth associated -2.16371