CRCGN013_HEPG2_24H:J13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN013_HEPG2_24H:J13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 9.87155
ATP11B ATPase, class VI, type 11B 5.9658
LCN2 lipocalin 2 4.86987
SQOR sulfide quinone oxidoreductase 4.5545
EPHB2 EPH receptor B2 3.60137
TBC1D31 TBC1 domain family, member 31 3.38473
PLSCR3 phospholipid scramblase 3 3.12339
NOTCH1 notch 1 3.07551
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.93003
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.80817
HDGFL3 HDGF like 3 2.71797
GSTZ1 glutathione S-transferase zeta 1 2.70008
TBP TATA box binding protein 2.55982
CBR3 carbonyl reductase 3 2.43202
BAD BCL2-associated agonist of cell death 2.2974
BACE1 beta-site APP-cleaving enzyme 1 2.22587
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.22331
LOC122526780 uncharacterized LOC122526780 2.09008
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.04552
RPIA ribose 5-phosphate isomerase A 2.01802

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -5.24918
NUP85 nucleoporin 85kDa -4.36175
DUSP6 dual specificity phosphatase 6 -4.0222
LDHD lactate dehydrogenase D -4.01331
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.93268
TSPAN4 tetraspanin 4 -3.77522
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.63562
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.28974
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.14941
ILK integrin-linked kinase -3.05561
PEG10 paternally expressed 10 -2.92262
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.85225
MRPS7 mitochondrial ribosomal protein S7 -2.83259
PLK1 polo-like kinase 1 -2.81682
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.73804
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.73239
CCNB1 cyclin B1 -2.73175
PCNA proliferating cell nuclear antigen -2.69185
ADI1 acireductone dioxygenase 1 -2.68824
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.64158
OXA1L oxidase (cytochrome c) assembly 1-like -2.595
DSG2 desmoglein 2 -2.58973
CHMP4B charged multivesicular body protein 4B -2.54165
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.38166
CLDN5 claudin 5 -2.31547
GNAS GNAS complex locus -2.26461
BRINP1 bone morphogenetic protein/retinoic acid inducible neural-specific 1 -2.25979
VAT1 vesicle amine transport 1 -2.25784
ZNF586 zinc finger protein 586 -2.2572
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 -2.18198
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.18021
CCNB2 cyclin B2 -2.15307
MTREX Mtr4 exosome RNA helicase -2.15061
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.14491
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.14372
EIF5 eukaryotic translation initiation factor 5 -2.1181
CLCN5 chloride channel, voltage-sensitive 5 -2.10971
SAP30BP SAP30 binding protein -2.08777
TM9SF3 transmembrane 9 superfamily member 3 -2.06234
HOXC10 homeobox C10 -2.03523