CRCGN013_HEPG2_24H:J19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description CH-223191 21.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

162 genes differentially expressed following the CRCGN013_HEPG2_24H:J19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 8.00877
C2CD2 C2 calcium-dependent domain containing 2 7.26349
CXCL2 chemokine (C-X-C motif) ligand 2 6.83573
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 6.43428
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.90437
CDC45 cell division cycle 45 5.52119
SSBP2 single-stranded DNA binding protein 2 5.23059
TRIB3 tribbles pseudokinase 3 5.12845
HLA-DRA major histocompatibility complex, class II, DR alpha 4.81572
INPP1 inositol polyphosphate-1-phosphatase 4.32469
PRKCH protein kinase C, eta 4.22031
MOK MOK protein kinase 3.94606
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.88831
STXBP1 syntaxin binding protein 1 3.87629
CNPY3 canopy FGF signaling regulator 3 3.84658
FCHO1 FCH domain only 1 3.77781
MAMLD1 mastermind-like domain containing 1 3.74333
CTSL cathepsin L 3.65263
GSTZ1 glutathione S-transferase zeta 1 3.53072
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.42609
SNAP25 synaptosomal-associated protein, 25kDa 3.30676
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.26781
CBR3 carbonyl reductase 3 3.2568
UBQLN2 ubiquilin 2 3.25052
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.13335
PLS1 plastin 1 3.13078
BZW2 basic leucine zipper and W2 domains 2 3.10602
HDGFL3 HDGF like 3 3.06644
ADRB2 adrenoceptor beta 2, surface 3.0482
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.98331
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.9435
HLA-DMA major histocompatibility complex, class II, DM alpha 2.89882
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.86082
TAC4 tachykinin 4 (hemokinin) 2.86014
LRP10 low density lipoprotein receptor-related protein 10 2.83159
VAT1 vesicle amine transport 1 2.77748
TBP TATA box binding protein 2.77274
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.76166
FBXO7 F-box protein 7 2.73885
CCL2 chemokine (C-C motif) ligand 2 2.72164
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.67769
STK10 serine/threonine kinase 10 2.56271
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.46042
ECD ecdysoneless homolog (Drosophila) 2.41317
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.38734
HLF hepatic leukemia factor 2.37885
MED15 mediator complex subunit 15 2.36175
SQSTM1 sequestosome 1 2.31863
IER3 immediate early response 3 2.30811
RBPMS RNA binding protein with multiple splicing 2.29011
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.27286
RBM15B RNA binding motif protein 15B 2.26192
IDE insulin-degrading enzyme 2.25205
TRAK2 trafficking protein, kinesin binding 2 2.24773
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 2.21854
E2F2 E2F transcription factor 2 2.20975
PEX11A peroxisomal biogenesis factor 11 alpha 2.20347
BRAF B-Raf proto-oncogene, serine/threonine kinase 2.17996
DMTN dematin actin binding protein 2.12866
TRIB1 tribbles pseudokinase 1 2.12823
PGAP6 post-GPI attachment to proteins 6 2.10518
TXNRD1 thioredoxin reductase 1 2.08489
LOC128125814 uncharacterized LOC128125814 2.08171
APOC1 apolipoprotein C-I 2.07575
STXBP2 syntaxin binding protein 2 2.06112
MX1 MX dynamin-like GTPase 1 2.06052
BAG2 BCL2-associated athanogene 2 2.03436
TSC22D1 TSC22 domain family, member 1 2.02216
NPY neuropeptide Y 2.00782
PRAF2 PRA1 domain family, member 2 2.00146

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -6.53073
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.84339
CCNB1 cyclin B1 -5.36475
FHL2 four and a half LIM domains 2 -4.29051
AURKB aurora kinase B -4.193
NGRN neugrin, neurite outgrowth associated -4.1642
HAT1 histone acetyltransferase 1 -4.0724
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.97044
TOP2A topoisomerase (DNA) II alpha 170kDa -3.92697
MELK maternal embryonic leucine zipper kinase -3.81899
TLCD3A TLC domain containing 3A -3.73204
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.57744
KDM3A lysine (K)-specific demethylase 3A -3.4456
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.42271
OXA1L oxidase (cytochrome c) assembly 1-like -3.32605
STMN1 stathmin 1 -3.31534
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -3.27868
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.25081
CHEK1 checkpoint kinase 1 -3.1302
RFC2 replication factor C (activator 1) 2, 40kDa -3.05761
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.04856
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -3.04801
PDLIM1 PDZ and LIM domain 1 -3.0273
NUP85 nucleoporin 85kDa -3.02623
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.96727
SESN1 sestrin 1 -2.92916
TBC1D10C TBC1 domain family, member 10C -2.92638
TCTN1 tectonic family member 1 -2.92344
BIRC5 baculoviral IAP repeat containing 5 -2.91992
PSRC1 proline/serine-rich coiled-coil 1 -2.88331
CCNA2 cyclin A2 -2.86521
PLK1 polo-like kinase 1 -2.85614
NFIL3 nuclear factor, interleukin 3 regulated -2.81192
TEX10 testis expressed 10 -2.76572
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.75222
ZNF274 zinc finger protein 274 -2.75009
FBXL12 F-box and leucine-rich repeat protein 12 -2.64458
PIH1D1 PIH1 domain containing 1 -2.63225
PGAM4 phosphoglycerate mutase family member 4 -2.59308
COA7 cytochrome c oxidase assembly factor 7 (putative) -2.57448
COG4 component of oligomeric golgi complex 4 -2.56042
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.5589
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 -2.53027
TXNDC9 thioredoxin domain containing 9 -2.52601
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.5247
CDC20 cell division cycle 20 -2.48221
CRABP1 cellular retinoic acid binding protein 1 -2.47659
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.47078
SPAG4 sperm associated antigen 4 -2.4594
CKAP2 cytoskeleton associated protein 2 -2.44212
TRMT61B tRNA methyltransferase 61B -2.36913
KIF11 kinesin family member 11 -2.36194
CLDN6 claudin 6 -2.36117
RPUSD2 RNA pseudouridylate synthase domain containing 2 -2.35649
STARD7 StAR-related lipid transfer (START) domain containing 7 -2.33537
RBM15 RNA binding motif protein 15 -2.32603
HMG20B high mobility group 20B -2.31458
KDM1A lysine (K)-specific demethylase 1A -2.31259
PIMREG PICALM interacting mitotic regulator -2.31182
VDAC1 voltage-dependent anion channel 1 -2.30056
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.30049
TRAPPC8 trafficking protein particle complex 8 -2.29378
LBR lamin B receptor -2.28572
CDK1 cyclin-dependent kinase 1 -2.27747
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.25626
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) -2.22342
TMEM109 transmembrane protein 109 -2.20795
ZC3H4 zinc finger CCCH-type containing 4 -2.18749
IL32 interleukin 32 -2.18543
COPS7A COP9 signalosome subunit 7A -2.16909
RGS2 regulator of G-protein signaling 2 -2.16852
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.1676
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.14443
POLR1G RNA polymerase I subunit G -2.14001
C5 complement component 5 -2.13095
TRIM31 tripartite motif containing 31 -2.1184
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.11795
INCENP inner centromere protein antigens 135/155kDa -2.1166
MUC6 mucin 6, oligomeric mucus/gel-forming -2.11497
TLR4 toll-like receptor 4 -2.10348
CDH12 cadherin 12, type 2 (N-cadherin 2) -2.06486
ZDHHC6 zinc finger, DHHC-type containing 6 -2.06249
UBE2C ubiquitin-conjugating enzyme E2C -2.06188
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.06139
ERCC6L excision repair cross-complementation group 6-like -2.05776
INTS3 integrator complex subunit 3 -2.04987
GLB1L2 galactosidase, beta 1-like 2 -2.0464
ZMIZ1 zinc finger, MIZ-type containing 1 -2.02864
MCM6 minichromosome maintenance complex component 6 -2.01533
BORA bora, aurora kinase A activator -2.0081
DIO3 deiodinase, iodothyronine, type III -2.00686
TOPBP1 topoisomerase (DNA) II binding protein 1 -2.00304