CRCGN013_HEPG2_24H:J20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description CH-223191 10.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

111 genes differentially expressed following the CRCGN013_HEPG2_24H:J20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 10.0
CIAO3 cytosolic iron-sulfur assembly component 3 7.07996
PNKP polynucleotide kinase 3'-phosphatase 5.29388
PPARG peroxisome proliferator-activated receptor gamma 4.22969
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 4.0258
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.99387
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.88439
NOTCH1 notch 1 3.68622
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.41983
DYNLT3 dynein, light chain, Tctex-type 3 3.31411
LCN2 lipocalin 2 2.92786
KLHL9 kelch-like family member 9 2.88564
SSBP2 single-stranded DNA binding protein 2 2.88467
PFKL phosphofructokinase, liver 2.74922
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.70005
MUC13 mucin 13, cell surface associated 2.62711
RAB21 RAB21, member RAS oncogene family 2.61093
SPRED2 sprouty-related, EVH1 domain containing 2 2.55895
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.54618
RBP3 retinol binding protein 3, interstitial 2.53998
GPER1 G protein-coupled estrogen receptor 1 2.5145
JADE2 jade family PHD finger 2 2.51352
LGALS4 lectin, galactoside-binding, soluble, 4 2.49142
TDRD12 tudor domain containing 12 2.48369
CCNH cyclin H 2.45673
GUCY2C guanylate cyclase 2C 2.4479
LSR lipolysis stimulated lipoprotein receptor 2.42329
SULF1 sulfatase 1 2.37655
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 2.33388
ANO3 anoctamin 3 2.32953
INPP1 inositol polyphosphate-1-phosphatase 2.28722
IHH indian hedgehog 2.28131
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.27351
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.27332
HR hair growth associated 2.26447
VIL1 villin 1 2.24397
DLX6 distal-less homeobox 6 2.24323
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 2.23191
FRMD1 FERM domain containing 1 2.22203
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.22196
HEYL hes-related family bHLH transcription factor with YRPW motif-like 2.21626
TCL1B T-cell leukemia/lymphoma 1B 2.21502
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 2.2029
ANKRD40CL ANKRD40 C-terminal like 2.20265
RNF186 ring finger protein 186 2.20025
GUCA2A guanylate cyclase activator 2A (guanylin) 2.19837
JUP junction plakoglobin 2.19236
KDM5A lysine (K)-specific demethylase 5A 2.17956
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 2.17223
MEP1A meprin A, alpha (PABA peptide hydrolase) 2.15155
RAB40C RAB40C, member RAS oncogene family 2.14793
RFX2 regulatory factor X, 2 (influences HLA class II expression) 2.14706
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.14561
EPS8L3 EPS8-like 3 2.13866
MYO1A myosin IA 2.13633
TRIM15 tripartite motif containing 15 2.12938
ZNF324B zinc finger protein 324B 2.12412
FABP1 fatty acid binding protein 1, liver 2.12077
GPX2 glutathione peroxidase 2 2.11831
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 2.11448
CAMKV CaM kinase-like vesicle-associated 2.11353
CDC45 cell division cycle 45 2.09872
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 2.09518
CCDC134 coiled-coil domain containing 134 2.09078
HPCA hippocalcin 2.09051
GIPC2 GIPC PDZ domain containing family, member 2 2.08805
PALM paralemmin 2.07345
TPSD1 tryptase delta 1 2.07249
TM4SF20 transmembrane 4 L six family member 20 2.07021
PLCH2 phospholipase C, eta 2 2.06742
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 2.06716
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 2.0567
SP3 Sp3 transcription factor 2.04074
AMN amnion associated transmembrane protein 2.0266
WASHC3 WASH complex subunit 3 2.02203
GATA2 GATA binding protein 2 2.00721
LPAR2 lysophosphatidic acid receptor 2 2.00414

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -7.61773
ZNF274 zinc finger protein 274 -5.40768
NUP85 nucleoporin 85kDa -4.67692
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.57634
NT5DC2 5'-nucleotidase domain containing 2 -3.59968
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.49913
ETFB electron-transfer-flavoprotein, beta polypeptide -3.40233
MRPS2 mitochondrial ribosomal protein S2 -3.30368
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.23628
OXA1L oxidase (cytochrome c) assembly 1-like -3.17195
ILK integrin-linked kinase -3.12911
CDK6 cyclin-dependent kinase 6 -3.00164
AURKB aurora kinase B -2.71535
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.70087
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.60694
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.51398
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.51305
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.48081
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.4187
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.41753
KCTD2 potassium channel tetramerization domain containing 2 -2.31325
LY86 lymphocyte antigen 86 -2.28458
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.26843
HMG20B high mobility group 20B -2.26084
CCNB2 cyclin B2 -2.22792
UBE3C ubiquitin protein ligase E3C -2.18945
PSRC1 proline/serine-rich coiled-coil 1 -2.17087
KIF14 kinesin family member 14 -2.13326
MRPS7 mitochondrial ribosomal protein S7 -2.10916
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.10359
JPT1 Jupiter microtubule associated homolog 1 -2.07366
IER5 immediate early response 5 -2.06967
BCL6 B-cell CLL/lymphoma 6 -2.04206
PLK1 polo-like kinase 1 -2.02117