CRCGN013_HEPG2_24H:J24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description CH-223191 0.66 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

51 genes differentially expressed following the CRCGN013_HEPG2_24H:J24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STK10 serine/threonine kinase 10 8.60932
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.8168
SNAP25 synaptosomal-associated protein, 25kDa 3.97329
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.70647
LCN2 lipocalin 2 3.64074
PPARG peroxisome proliferator-activated receptor gamma 3.52831
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.46293
RAB11FIP1 RAB11 family interacting protein 1 (class I) 3.20853
COPS7A COP9 signalosome subunit 7A 2.8835
MAP7 microtubule-associated protein 7 2.88246
PLSCR3 phospholipid scramblase 3 2.83138
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.68798
CEMIP2 cell migration inducing hyaluronidase 2 2.5427
CCNF cyclin F 2.52872
TSLIG3A tRNA splicing ligase complex subunit 3A 2.47932
MARCKS myristoylated alanine-rich protein kinase C substrate 2.36013
PLXNC1 plexin C1 2.35641
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.34764
GPATCH8 G patch domain containing 8 2.30297
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.22326
ZNF318 zinc finger protein 318 2.2206
CPZ carboxypeptidase Z 2.17202
INPP5F inositol polyphosphate-5-phosphatase F 2.13613
CSH2 chorionic somatomammotropin hormone 2 2.13161
MTCL1 microtubule crosslinking factor 1 2.10511
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.09124
SCGN secretagogin, EF-hand calcium binding protein 2.07551
COQ3 coenzyme Q3 methyltransferase 2.04919
RIN3 Ras and Rab interactor 3 2.04637
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 2.0337
S100A1 S100 calcium binding protein A1 2.01005

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -8.54325
GNAS GNAS complex locus -6.31781
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.13332
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.04585
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.75939
CCNB2 cyclin B2 -3.57938
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -3.56675
CCDC86 coiled-coil domain containing 86 -3.52611
UGDH UDP-glucose 6-dehydrogenase -3.51647
GDF15 growth differentiation factor 15 -3.28026
EIF5 eukaryotic translation initiation factor 5 -3.12908
IFRD2 interferon-related developmental regulator 2 -2.78735
FLNB filamin B, beta -2.50571
REEP5 receptor accessory protein 5 -2.50475
FBXL12 F-box and leucine-rich repeat protein 12 -2.29544
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -2.15502
NRIP1 nuclear receptor interacting protein 1 -2.15495
CHEK1 checkpoint kinase 1 -2.06749
LOC114841035 uncharacterized LOC114841035 -2.0528
GRPEL1 GrpE-like 1, mitochondrial (E. coli) -2.00131