CRCGN013_HEPG2_24H:K05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o-phenylenediamine.2hcl 2.55 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

700 genes differentially expressed following the CRCGN013_HEPG2_24H:K05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 10.0
INPP1 inositol polyphosphate-1-phosphatase 9.50644
BLCAP bladder cancer associated protein 9.01624
LRP10 low density lipoprotein receptor-related protein 10 8.79999
DDB2 damage-specific DNA binding protein 2, 48kDa 8.60388
ABHD4 abhydrolase domain containing 4 7.56699
MICALL1 MICAL-like 1 7.53488
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 7.41412
TUBB6 tubulin, beta 6 class V 7.09041
CNPY3 canopy FGF signaling regulator 3 6.85457
KIFBP kinesin family binding protein 6.8269
MYLK myosin light chain kinase 6.6531
NR1H2 nuclear receptor subfamily 1, group H, member 2 6.1081
CCDC92 coiled-coil domain containing 92 5.87036
MINDY1 MINDY lysine 48 deubiquitinase 1 5.84915
GPC1 glypican 1 5.79576
DUSP14 dual specificity phosphatase 14 5.73075
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 5.64632
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 5.58072
ADGRG1 adhesion G protein-coupled receptor G1 5.49719
IL4R interleukin 4 receptor 5.43873
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 5.37094
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 5.22485
SKIC2 SKI2 subunit of superkiller complex 5.17132
STX1A syntaxin 1A (brain) 5.02759
FOXJ3 forkhead box J3 4.99351
ASCC3 activating signal cointegrator 1 complex subunit 3 4.84008
KHDC4 KH domain containing 4, pre-mRNA splicing factor 4.83931
IGFBP3 insulin-like growth factor binding protein 3 4.83685
PRKCQ protein kinase C, theta 4.80597
KEAP1 kelch-like ECH-associated protein 1 4.73913
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 4.36188
TXNRD1 thioredoxin reductase 1 4.23606
PNKP polynucleotide kinase 3'-phosphatase 4.23328
LSR lipolysis stimulated lipoprotein receptor 4.22711
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.20605
TOR1A torsin family 1, member A (torsin A) 4.12506
TIMP2 TIMP metallopeptidase inhibitor 2 4.11149
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.10011
MVP major vault protein 4.06233
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 3.98002
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 3.93279
NISCH nischarin 3.90467
KLHL21 kelch-like family member 21 3.88768
PHLDA3 pleckstrin homology-like domain, family A, member 3 3.85081
XPC xeroderma pigmentosum, complementation group C 3.8434
TERF2IP telomeric repeat binding factor 2, interacting protein 3.8411
PLK3 polo-like kinase 3 3.83724
MCOLN1 mucolipin 1 3.80161
PRAF2 PRA1 domain family, member 2 3.77121
CDC45 cell division cycle 45 3.709
GADD45A growth arrest and DNA-damage-inducible, alpha 3.70027
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 3.64557
CASC3 cancer susceptibility candidate 3 3.62549
AEN apoptosis enhancing nuclease 3.6164
DHRS7 dehydrogenase/reductase (SDR family) member 7 3.58311
CCND3 cyclin D3 3.57658
MAPK13 mitogen-activated protein kinase 13 3.53501
ULK1 unc-51 like autophagy activating kinase 1 3.5255
MAP7D1 MAP7 domain containing 1 3.49179
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 3.4585
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.40446
SQOR sulfide quinone oxidoreductase 3.38154
FOSL1 FOS-like antigen 1 3.37816
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.36633
ANKRD10 ankyrin repeat domain 10 3.34976
SETD1A SET domain containing 1A 3.34834
ATG9A autophagy related 9A 3.34643
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.32855
TIGAR TP53 induced glycolysis regulatory phosphatase 3.32238
PRKCD protein kinase C, delta 3.3184
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.30225
LCN2 lipocalin 2 3.30121
CYTH2 cytohesin 2 3.28157
ZNF219 zinc finger protein 219 3.27853
CIAO3 cytosolic iron-sulfur assembly component 3 3.24966
NOTCH1 notch 1 3.24655
IER3 immediate early response 3 3.24283
TBC1D31 TBC1 domain family, member 31 3.2156
COL7A1 collagen, type VII, alpha 1 3.20232
STIMATE STIM activating enhancer 3.19157
E2F2 E2F transcription factor 2 3.17561
SMAD3 SMAD family member 3 3.09797
TOMM34 translocase of outer mitochondrial membrane 34 3.08508
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 3.0487
SCPEP1 serine carboxypeptidase 1 3.02917
FDXR ferredoxin reductase 3.00303
AGAP4 ArfGAP with GTPase domain, ankyrin repeat and PH domain 4 2.96124
BAD BCL2-associated agonist of cell death 2.95984
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.92457
RABGGTA Rab geranylgeranyltransferase, alpha subunit 2.91746
KLHL36 kelch-like family member 36 2.91587
ADGRE5 adhesion G protein-coupled receptor E5 2.91451
DDR1 discoidin domain receptor tyrosine kinase 1 2.88343
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 2.8747
WDR73 WD repeat domain 73 2.87302
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated 2.86778
INTS3 integrator complex subunit 3 2.85507
PPARG peroxisome proliferator-activated receptor gamma 2.85173
PIGG phosphatidylinositol glycan anchor biosynthesis, class G 2.84747
RALB v-ral simian leukemia viral oncogene homolog B 2.84277
HSPA1A heat shock 70kDa protein 1A 2.84171
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 2.83795
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.83793
CLK3 CDC-like kinase 3 2.83338
SQSTM1 sequestosome 1 2.82601
CIC capicua transcriptional repressor 2.82246
GSDME gasdermin E 2.82028
RAP1GAP RAP1 GTPase activating protein 2.80109
RIN1 Ras and Rab interactor 1 2.79421
KDM5A lysine (K)-specific demethylase 5A 2.76022
LOC122526780 uncharacterized LOC122526780 2.75883
MBOAT7 membrane bound O-acyltransferase domain containing 7 2.73194
UNC13D unc-13 homolog D (C. elegans) 2.72758
NUP58 nucleoporin 58 2.72402
CLBA1 clathrin binding box of aftiphilin containing 1 2.72322
ALAS1 5'-aminolevulinate synthase 1 2.71343
CGRRF1 cell growth regulator with ring finger domain 1 2.71236
IL17RA interleukin 17 receptor A 2.71109
ATG2A autophagy related 2A 2.70288
GSAP gamma-secretase activating protein 2.70033
ERCC3 excision repair cross-complementation group 3 2.67072
BECN1 beclin 1, autophagy related 2.66272
TNIP1 TNFAIP3 interacting protein 1 2.6525
SGSH N-sulfoglucosamine sulfohydrolase 2.64998
OSGIN1 oxidative stress induced growth inhibitor 1 2.63455
RALGDS ral guanine nucleotide dissociation stimulator 2.63039
GAA glucosidase, alpha; acid 2.6223
MICALL2 MICAL-like 2 2.61736
SCAND1 SCAN domain containing 1 2.61667
LIF leukemia inhibitory factor 2.61284
PPIE peptidylprolyl isomerase E (cyclophilin E) 2.6077
ZNF79 zinc finger protein 79 2.60407
FOXO4 forkhead box O4 2.58257
TGFB1I1 transforming growth factor beta 1 induced transcript 1 2.57895
FUZ fuzzy planar cell polarity protein 2.56673
TP53I3 tumor protein p53 inducible protein 3 2.5618
E4F1 E4F transcription factor 1 2.55918
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 2.55883
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 2.55765
TRIT1 tRNA isopentenyltransferase 1 2.5558
ADGRD2 adhesion G protein-coupled receptor D2 2.55573
RNF25 ring finger protein 25 2.54413
RFX5 regulatory factor X, 5 (influences HLA class II expression) 2.54378
OFD1 oral-facial-digital syndrome 1 2.53502
LAMB3 laminin, beta 3 2.5328
FASN fatty acid synthase 2.53095
BBC3 BCL2 binding component 3 2.52538
CSRNP2 cysteine-serine-rich nuclear protein 2 2.52533
DUSP3 dual specificity phosphatase 3 2.5246
CHD8 chromodomain helicase DNA binding protein 8 2.52414
COL4A6 collagen, type IV, alpha 6 2.51065
FBRS fibrosin 2.50539
GBA1 glucosylceramidase beta 1 2.50473
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.50417
GATA2 GATA binding protein 2 2.50408
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 2.49695
POMT1 protein-O-mannosyltransferase 1 2.48971
DUSP6 dual specificity phosphatase 6 2.4871
TLE6 transducin-like enhancer of split 6 2.47846
TCF15 transcription factor 15 (basic helix-loop-helix) 2.47408
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 2.46723
PTPN6 protein tyrosine phosphatase, non-receptor type 6 2.45883
SUN2 Sad1 and UNC84 domain containing 2 2.45548
TRIM8 tripartite motif containing 8 2.45373
ARID5A AT rich interactive domain 5A (MRF1-like) 2.43218
GTPBP2 GTP binding protein 2 2.42702
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 2.42635
FHIP2B FHF complex subunit HOOK interacting protein 2B 2.42547
ATG4A autophagy related 4A, cysteine peptidase 2.41249
ESYT1 extended synaptotagmin-like protein 1 2.41007
SIN3B SIN3 transcription regulator family member B 2.40823
PORCN porcupine homolog (Drosophila) 2.40569
SCMH1 sex comb on midleg homolog 1 (Drosophila) 2.39959
IGF1R insulin-like growth factor 1 receptor 2.39845
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor 2.39289
PI4KB phosphatidylinositol 4-kinase, catalytic, beta 2.39167
NPDC1 neural proliferation, differentiation and control, 1 2.39034
CCNL2 cyclin L2 2.38992
PICK1 protein interacting with PRKCA 1 2.38988
FAM110D family with sequence similarity 110, member D 2.38792
PRKD2 protein kinase D2 2.38524
LRRC41 leucine rich repeat containing 41 2.3747
KLK2 kallikrein-related peptidase 2 2.37391
HBEGF heparin-binding EGF-like growth factor 2.36887
ANO1 anoctamin 1, calcium activated chloride channel 2.36278
ULBP2 UL16 binding protein 2 2.36194
MOSPD1 motile sperm domain containing 1 2.36174
ZNF212 zinc finger protein 212 2.35765
ACOT9 acyl-CoA thioesterase 9 2.35261
CDK5RAP1 CDK5 regulatory subunit associated protein 1 2.34629
IFT57 intraflagellar transport 57 2.34089
YY1AP1 YY1 associated protein 1 2.33796
TESK1 testis-specific kinase 1 2.33633
NPY neuropeptide Y 2.33573
TRADD TNFRSF1A-associated via death domain 2.33207
PROCR protein C receptor, endothelial 2.32737
PKM pyruvate kinase, muscle 2.32651
RNF40 ring finger protein 40, E3 ubiquitin protein ligase 2.31716
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa 2.31453
GRN granulin 2.31347
MON1B MON1 secretory trafficking family member B 2.31347
DOLK dolichol kinase 2.31147
ZMAT3 zinc finger, matrin-type 3 2.31075
LOC124904942 uncharacterized LOC124904942 2.30919
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 2.3088
VPS9D1 VPS9 domain containing 1 2.30859
TACC2 transforming, acidic coiled-coil containing protein 2 2.30827
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.30309
GIPC1 GIPC PDZ domain containing family, member 1 2.30205
THBS3 thrombospondin 3 2.30136
MOK MOK protein kinase 2.29208
KDM3A lysine (K)-specific demethylase 3A 2.28782
HDAC7 histone deacetylase 7 2.28412
YJU2B YJU2 splicing factor homolog B 2.28401
ADAT1 adenosine deaminase, tRNA-specific 1 2.28214
TRIP12 thyroid hormone receptor interactor 12 2.28001
CSNK1E casein kinase 1, epsilon 2.27949
SH3BP1 SH3-domain binding protein 1 2.27689
STOM stomatin 2.27314
ZBTB48 zinc finger and BTB domain containing 48 2.2729
LAMC2 laminin, gamma 2 2.26866
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 2.26671
ELAVL3 ELAV like neuron-specific RNA binding protein 3 2.26338
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 2.26056
BAZ1A bromodomain adjacent to zinc finger domain, 1A 2.25745
PHF1 PHD finger protein 1 2.25321
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 2.25234
DLL3 delta-like 3 (Drosophila) 2.25099
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 2.24603
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 2.24445
ANXA8L1 annexin A8-like 1 2.24372
THSD1 thrombospondin, type I, domain containing 1 2.24256
ADRB2 adrenoceptor beta 2, surface 2.23972
AMPD2 adenosine monophosphate deaminase 2 2.23838
VAT1 vesicle amine transport 1 2.23447
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 2.2337
CAMTA2 calmodulin binding transcription activator 2 2.23259
COL17A1 collagen, type XVII, alpha 1 2.23241
PCNP PEST proteolytic signal containing nuclear protein 2.2321
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 2.23137
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 2.23106
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 2.23014
IRF3 interferon regulatory factor 3 2.21845
BARX1 BARX homeobox 1 2.21223
CTSL cathepsin L 2.20755
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 2.20671
DNM2 dynamin 2 2.20267
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.20111
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 2.20095
HOXD11 homeobox D11 2.19919
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 2.19773
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.19627
KRT7 keratin 7, type II 2.1934
ALG12 ALG12, alpha-1,6-mannosyltransferase 2.19014
GPN2 GPN-loop GTPase 2 2.18953
GALE UDP-galactose-4-epimerase 2.18934
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 2.18353
KIFC3 kinesin family member C3 2.18332
SLC12A9 solute carrier family 12, member 9 2.18042
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 2.17958
MAP3K14 mitogen-activated protein kinase kinase kinase 14 2.17834
RCOR3 REST corepressor 3 2.17752
MBTPS1 membrane-bound transcription factor peptidase, site 1 2.17484
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2.17429
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.16557
COG7 component of oligomeric golgi complex 7 2.15913
GJB5 gap junction protein, beta 5, 31.1kDa 2.15801
TSC22D4 TSC22 domain family, member 4 2.15591
C1QL1 complement component 1, q subcomponent-like 1 2.15116
RTL10 retrotransposon Gag like 10 2.14645
DGKA diacylglycerol kinase, alpha 80kDa 2.14325
ZNF282 zinc finger protein 282 2.14277
MYOF myoferlin 2.13634
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 2.13175
CDIP1 cell death-inducing p53 target 1 2.12572
MAN2C1 mannosidase, alpha, class 2C, member 1 2.12464
NOP2 NOP2 nucleolar protein 2.12052
PXDC1 PX domain containing 1 2.11848
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 2.11471
DNM1L dynamin 1-like 2.11001
IGHMBP2 immunoglobulin mu binding protein 2 2.10941
CUL7 cullin 7 2.10526
VILL villin-like 2.10434
ZNF646 zinc finger protein 646 2.10352
FOXK2 forkhead box K2 2.09917
HSPB8 heat shock 22kDa protein 8 2.0965
POMT2 protein-O-mannosyltransferase 2 2.09604
CPNE7 copine VII 2.09102
TRAPPC14 trafficking protein particle complex subunit 14 2.08818
NPIPB5 nuclear pore complex interacting protein family, member B5 2.08459
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 2.08387
MACF1 microtubule-actin crosslinking factor 1 2.08257
RNPEP arginyl aminopeptidase (aminopeptidase B) 2.08045
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 2.07944
AQP3 aquaporin 3 (Gill blood group) 2.07924
PLCH2 phospholipase C, eta 2 2.07909
CORO7-PAM16 CORO7-PAM16 readthrough 2.07717
GOLGA8A golgin A8 family, member A 2.0764
CROT carnitine O-octanoyltransferase 2.07307
ERCC5 excision repair cross-complementation group 5 2.06958
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 2.06459
ERCC1 excision repair cross-complementation group 1 2.06403
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 2.06112
FSTL3 follistatin-like 3 (secreted glycoprotein) 2.05827
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 2.05788
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.05496
KCNK3 potassium channel, two pore domain subfamily K, member 3 2.05386
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 2.04946
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) 2.0492
TRIM11 tripartite motif containing 11 2.04896
LTK leukocyte receptor tyrosine kinase 2.04758
SLC35F6 solute carrier family 35, member F6 2.04751
NT5DC3 5'-nucleotidase domain containing 3 2.03493
SYNGR3 synaptogyrin 3 2.02697
SPEG SPEG complex locus 2.02556
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 2.02441
PYGB phosphorylase, glycogen; brain 2.02336
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 2.02248
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1 2.02094
PGAP6 post-GPI attachment to proteins 6 2.02067
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 2.02016
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 2.02014
GPR87 G protein-coupled receptor 87 2.01645
CPTP ceramide-1-phosphate transfer protein 2.01562
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 2.01467
NOSIP nitric oxide synthase interacting protein 2.01306
ITPKC inositol-trisphosphate 3-kinase C 2.01195
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 2.0112
TMBIM1 transmembrane BAX inhibitor motif containing 1 2.00608
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 2.00471

decreased expression

Symbol Name Standardized Value
C5 complement component 5 -9.13085
FGFR4 fibroblast growth factor receptor 4 -8.19612
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -7.87954
PSRC1 proline/serine-rich coiled-coil 1 -7.27932
PGM1 phosphoglucomutase 1 -6.87127
LDHD lactate dehydrogenase D -6.75452
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -6.30636
RPIA ribose 5-phosphate isomerase A -6.11772
AURKB aurora kinase B -6.11503
ISOC1 isochorismatase domain containing 1 -6.08448
CCNA2 cyclin A2 -5.82293
PROS1 protein S (alpha) -5.79021
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -5.768
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -5.63585
PYCR1 pyrroline-5-carboxylate reductase 1 -5.57237
STMN1 stathmin 1 -5.55566
PCCB propionyl CoA carboxylase, beta polypeptide -5.33719
ALDOC aldolase C, fructose-bisphosphate -5.19125
RSU1 Ras suppressor protein 1 -5.13367
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -5.10288
TCTN1 tectonic family member 1 -4.98294
PECR peroxisomal trans-2-enoyl-CoA reductase -4.94984
PLK1 polo-like kinase 1 -4.82871
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.82422
USP6NL USP6 N-terminal like -4.73984
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.67408
ZW10 zw10 kinetochore protein -4.6076
NIPSNAP1 nipsnap homolog 1 (C. elegans) -4.57581
SOAT2 sterol O-acyltransferase 2 -4.50565
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.48579
ENOPH1 enolase-phosphatase 1 -4.47
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.35862
MNAT1 MNAT CDK-activating kinase assembly factor 1 -4.35548
HMGA2 high mobility group AT-hook 2 -4.27519
HEATR1 HEAT repeat containing 1 -4.24787
LBR lamin B receptor -4.22814
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -4.21417
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.16814
BLMH bleomycin hydrolase -4.03585
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -4.0111
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.97318
PLS1 plastin 1 -3.97218
CDK4 cyclin-dependent kinase 4 -3.95923
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -3.95066
CDC20 cell division cycle 20 -3.86467
C2CD5 C2 calcium-dependent domain containing 5 -3.73105
UBE2C ubiquitin-conjugating enzyme E2C -3.7308
HADH hydroxyacyl-CoA dehydrogenase -3.73051
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.70856
ELP4 elongator acetyltransferase complex subunit 4 -3.65918
ANO10 anoctamin 10 -3.64778
A1CF APOBEC1 complementation factor -3.63069
PXMP2 peroxisomal membrane protein 2, 22kDa -3.61537
ILK integrin-linked kinase -3.58204
APOC3 apolipoprotein C-III -3.56399
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -3.50799
UGDH UDP-glucose 6-dehydrogenase -3.47555
DENND2D DENN/MADD domain containing 2D -3.4613
APOM apolipoprotein M -3.38082
MYC v-myc avian myelocytomatosis viral oncogene homolog -3.3683
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -3.36018
CASP3 caspase 3, apoptosis-related cysteine peptidase -3.35599
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -3.33553
AMBP alpha-1-microglobulin/bikunin precursor -3.32758
PDIA5 protein disulfide isomerase family A, member 5 -3.30651
BIRC5 baculoviral IAP repeat containing 5 -3.28959
NRIP1 nuclear receptor interacting protein 1 -3.27218
SEC61G Sec61 gamma subunit -3.26462
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 -3.26284
HPR haptoglobin-related protein -3.25528
APOH apolipoprotein H (beta-2-glycoprotein I) -3.23674
BZW2 basic leucine zipper and W2 domains 2 -3.22568
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.20485
TMEM97 transmembrane protein 97 -3.20082
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.19577
CPB2 carboxypeptidase B2 (plasma) -3.16967
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -3.16869
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -3.16827
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -3.15001
GCSH glycine cleavage system protein H (aminomethyl carrier) -3.1435
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -3.12757
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -3.12364
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 -3.10155
TM9SF3 transmembrane 9 superfamily member 3 -3.10105
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -3.09716
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 -3.07739
PTGES3 prostaglandin E synthase 3 (cytosolic) -3.07453
MIS18A MIS18 kinetochore protein A -3.05751
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.03357
NFIL3 nuclear factor, interleukin 3 regulated -3.03001
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.01573
NUCB2 nucleobindin 2 -3.00002
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 -2.99589
NT5DC2 5'-nucleotidase domain containing 2 -2.99299
CADPS2 Ca++-dependent secretion activator 2 -2.99246
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 -2.99138
COL3A1 collagen, type III, alpha 1 -2.97418
PLG plasminogen -2.96345
MAP7 microtubule-associated protein 7 -2.95202
MRPL12 mitochondrial ribosomal protein L12 -2.94701
ADH6 alcohol dehydrogenase 6 (class V) -2.94201
HDAC2 histone deacetylase 2 -2.93654
MTTP microsomal triglyceride transfer protein -2.9351
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -2.93426
ASGR1 asialoglycoprotein receptor 1 -2.92846
MRPS17 mitochondrial ribosomal protein S17 -2.9093
AHSG alpha-2-HS-glycoprotein -2.88969
ANXA7 annexin A7 -2.88085
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.85655
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -2.84815
PAH phenylalanine hydroxylase -2.84721
GLYAT glycine-N-acyltransferase -2.84066
PARP1 poly (ADP-ribose) polymerase 1 -2.82307
RFC2 replication factor C (activator 1) 2, 40kDa -2.82259
MBL2 mannose-binding lectin (protein C) 2, soluble -2.82216
HSPD1 heat shock 60kDa protein 1 (chaperonin) -2.81616
ENY2 enhancer of yellow 2 homolog (Drosophila) -2.80772
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.78095
HAT1 histone acetyltransferase 1 -2.77348
EBAG9 estrogen receptor binding site associated, antigen, 9 -2.76737
MRPS30 mitochondrial ribosomal protein S30 -2.75639
MSMO1 methylsterol monooxygenase 1 -2.75323
APOA1 apolipoprotein A-I -2.71935
F9 coagulation factor IX -2.71897
GAS2 growth arrest-specific 2 -2.71003
FABP1 fatty acid binding protein 1, liver -2.70852
ANAPC10 anaphase promoting complex subunit 10 -2.70729
DCN decorin -2.7028
HPD 4-hydroxyphenylpyruvate dioxygenase -2.69103
HSPE1 heat shock 10kDa protein 1 -2.68781
SLC30A10 solute carrier family 30, member 10 -2.68264
APOA2 apolipoprotein A-II -2.67624
ICAM3 intercellular adhesion molecule 3 -2.66832
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.65288
ORM2 orosomucoid 2 -2.6171
LIPC lipase, hepatic -2.61325
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.60521
ELAVL1 ELAV like RNA binding protein 1 -2.59981
FAM117A family with sequence similarity 117, member A -2.59113
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) -2.58292
AKR1D1 aldo-keto reductase family 1, member D1 -2.58122
GMDS GDP-mannose 4,6-dehydratase -2.57922
AGMAT agmatine ureohydrolase (agmatinase) -2.57565
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 -2.56344
FBF1 Fas (TNFRSF6) binding factor 1 -2.5538
CTNND2 catenin (cadherin-associated protein), delta 2 -2.54364
SRSF3 serine/arginine-rich splicing factor 3 -2.53947
GNAS GNAS complex locus -2.53499
MCTS1 malignant T cell amplified sequence 1 -2.52836
MSRA methionine sulfoxide reductase A -2.52362
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.5229
CAMKMT calmodulin-lysine N-methyltransferase -2.51078
CCNB1 cyclin B1 -2.50616
CETN3 centrin, EF-hand protein, 3 -2.50454
CDC6 cell division cycle 6 -2.50007
COPZ1 coatomer protein complex, subunit zeta 1 -2.49775
MPC1 mitochondrial pyruvate carrier 1 -2.49535
CFHR2 complement factor H-related 2 -2.49246
ADI1 acireductone dioxygenase 1 -2.49061
TUBB4A tubulin, beta 4A class IVa -2.4897
HPX hemopexin -2.48692
ZIC1 Zic family member 1 -2.4851
RPL36AL ribosomal protein L36a-like -2.48259
PGAM4 phosphoglycerate mutase family member 4 -2.4808
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 -2.47897
PDGFD platelet derived growth factor D -2.47763
PHKB phosphorylase kinase, beta -2.47146
MYL9 myosin, light chain 9, regulatory -2.47105
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 -2.46641
SPDEF SAM pointed domain containing ETS transcription factor -2.46351
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide -2.4602
COL1A2 collagen, type I, alpha 2 -2.45462
CTSK cathepsin K -2.45417
C8A complement component 8, alpha polypeptide -2.45271
MELK maternal embryonic leucine zipper kinase -2.44993
SLC17A2 solute carrier family 17, member 2 -2.44849
ALDH1B1 aldehyde dehydrogenase 1 family, member B1 -2.44563
ZNF835 zinc finger protein 835 -2.44189
DNAAF2 dynein, axonemal, assembly factor 2 -2.43971
EXTL2 exostosin-like glycosyltransferase 2 -2.43961
LOC112694756 uncharaterized LOC112694756 -2.42586
PIGR polymeric immunoglobulin receptor -2.42545
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) -2.41998
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 -2.41981
E2F5 E2F transcription factor 5, p130-binding -2.41795
NUP37 nucleoporin 37kDa -2.41732
FGA fibrinogen alpha chain -2.41519
RABGAP1L RAB GTPase activating protein 1-like -2.40264
SDAD1 SDA1 domain containing 1 -2.3926
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.3922
UXT ubiquitously-expressed, prefoldin-like chaperone -2.39093
MRPL39 mitochondrial ribosomal protein L39 -2.39043
UBE2N ubiquitin-conjugating enzyme E2N -2.38775
ANAPC15 anaphase promoting complex subunit 15 -2.38761
VTN vitronectin -2.38119
AMDHD2 amidohydrolase domain containing 2 -2.38093
LYRM1 LYR motif containing 1 -2.37981
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) -2.37867
RABL3 RAB, member of RAS oncogene family-like 3 -2.37622
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 -2.37134
TRPM3 transient receptor potential cation channel, subfamily M, member 3 -2.36678
SERP1 stress-associated endoplasmic reticulum protein 1 -2.36352
RIT2 Ras-like without CAAX 2 -2.3628
INCENP inner centromere protein antigens 135/155kDa -2.35892
TRIL TLR4 interactor with leucine-rich repeats -2.35812
LMNB1 lamin B1 -2.35783
UBP1 upstream binding protein 1 (LBP-1a) -2.35733
PPID peptidylprolyl isomerase D -2.35414
POLR1G RNA polymerase I subunit G -2.35364
NTAQ1 N-terminal glutamine amidase 1 -2.34666
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -2.34511
ERH enhancer of rudimentary homolog (Drosophila) -2.34076
EFHD1 EF-hand domain family, member D1 -2.33318
AP1AR adaptor-related protein complex 1 associated regulatory protein -2.33203
SAA4 serum amyloid A4, constitutive -2.329
USP1 ubiquitin specific peptidase 1 -2.32811
EPB41L4B erythrocyte membrane protein band 4.1 like 4B -2.32677
RPS5 ribosomal protein S5 -2.3212
CCDC85B coiled-coil domain containing 85B -2.31938
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.31934
MOCS2 molybdenum cofactor synthesis 2 -2.31785
AURKA aurora kinase A -2.30747
GAR1 GAR1 ribonucleoprotein -2.30634
TMEM176A transmembrane protein 176A -2.30405
RGS7 regulator of G-protein signaling 7 -2.30222
MARCKSL1 MARCKS-like 1 -2.30118
C4BPB complement component 4 binding protein, beta -2.29843
AGXT alanine-glyoxylate aminotransferase -2.29366
ATP7B ATPase, Cu++ transporting, beta polypeptide -2.29067
CHMP6 charged multivesicular body protein 6 -2.29041
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 -2.28957
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa -2.28492
LOC102724594 splicing factor U2AF 35 kDa subunit -2.28438
LUM lumican -2.2744
GMFB glia maturation factor, beta -2.2727
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 -2.27008
FLT3 fms-related tyrosine kinase 3 -2.2694
QDPR quinoid dihydropteridine reductase -2.26386
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 -2.25917
APIP APAF1 interacting protein -2.25585
RABEPK Rab9 effector protein with kelch motifs -2.25254
CHEK2 checkpoint kinase 2 -2.24996
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 -2.24921
SELE selectin E -2.24825
FGF1 fibroblast growth factor 1 (acidic) -2.23965
TTC3 tetratricopeptide repeat domain 3 -2.23886
C4BPA complement component 4 binding protein, alpha -2.23817
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) -2.23533
KHK ketohexokinase (fructokinase) -2.23181
CRIPTO3 cripto, EGF-CFC family member 3 -2.23179
FBXO5 F-box protein 5 -2.23144
MACROD1 MACRO domain containing 1 -2.22566
CRADD CASP2 and RIPK1 domain containing adaptor with death domain -2.22312
MYO10 myosin X -2.21838
XYLT1 xylosyltransferase I -2.21815
FOXN2 forkhead box N2 -2.21785
PCCA propionyl CoA carboxylase, alpha polypeptide -2.21438
PLSCR4 phospholipid scramblase 4 -2.21107
PCNA proliferating cell nuclear antigen -2.20881
TMX1 thioredoxin-related transmembrane protein 1 -2.20842
RIOK2 RIO kinase 2 -2.20458
GLDC glycine dehydrogenase (decarboxylating) -2.2028
EBNA1BP2 EBNA1 binding protein 2 -2.20165
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 -2.2012
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 -2.19936
ATL2 atlastin GTPase 2 -2.19791
MAN1A1 mannosidase, alpha, class 1A, member 1 -2.19592
HNRNPM heterogeneous nuclear ribonucleoprotein M -2.19505
WASF3 WAS protein family, member 3 -2.19314
GCA grancalcin, EF-hand calcium binding protein -2.19157
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -2.19152
CFHR5 complement factor H-related 5 -2.191
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 -2.18964
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 -2.18854
SNRPF small nuclear ribonucleoprotein polypeptide F -2.1873
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 -2.18539
DSCC1 DNA replication and sister chromatid cohesion 1 -2.1837
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -2.18252
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -2.18167
SPC25 SPC25, NDC80 kinetochore complex component -2.17559
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -2.17473
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa -2.17329
SDC2 syndecan 2 -2.17321
CDO1 cysteine dioxygenase type 1 -2.16557
CLIC4 chloride intracellular channel 4 -2.16549
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 -2.16154
SIDT1 SID1 transmembrane family, member 1 -2.16026
FZD7 frizzled class receptor 7 -2.15959
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.15742
FAM3C family with sequence similarity 3, member C -2.15454
PDZD8 PDZ domain containing 8 -2.15281
ASGR2 asialoglycoprotein receptor 2 -2.15221
TMED2 transmembrane emp24 domain trafficking protein 2 -2.15197
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -2.15102
LRRC15 leucine rich repeat containing 15 -2.1509
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -2.14715
SRSF9 serine/arginine-rich splicing factor 9 -2.14185
FKTN fukutin -2.13801
ALAD aminolevulinate dehydratase -2.13759
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.13682
SEPHS1 selenophosphate synthetase 1 -2.13485
RGN regucalcin -2.13174
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -2.13051
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1 -2.13029
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta -2.12949
COL6A3 collagen, type VI, alpha 3 -2.12829
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -2.12695
LOC124907782 dual specificity protein phosphatase 22 -2.1242
PUM3 pumilio RNA binding family member 3 -2.12174
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 -2.12083
TMA16 translation machinery associated 16 homolog (S. cerevisiae) -2.11318
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta -2.11302
ADTRP androgen-dependent TFPI-regulating protein -2.11261
USP46 ubiquitin specific peptidase 46 -2.11255
APCS amyloid P component, serum -2.1061
VCAM1 vascular cell adhesion molecule 1 -2.10538
GTF2A2 general transcription factor IIA, 2, 12kDa -2.10325
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) -2.10274
NTS neurotensin -2.10177
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -2.09928
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 -2.09597
GDI2 GDP dissociation inhibitor 2 -2.09322
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.09278
TF transferrin -2.09146
CBR1 carbonyl reductase 1 -2.09094
SFXN1 sideroflexin 1 -2.08766
EXT1 exostosin glycosyltransferase 1 -2.08738
GALK1 galactokinase 1 -2.08476
MSH6 mutS homolog 6 -2.08441
PDHX pyruvate dehydrogenase complex, component X -2.08428
BSPRY B-box and SPRY domain containing -2.08272
RBM3 RNA binding motif (RNP1, RRM) protein 3 -2.08236
MRPL19 mitochondrial ribosomal protein L19 -2.08144
TRAPPC3 trafficking protein particle complex 3 -2.0765
FBXL7 F-box and leucine-rich repeat protein 7 -2.07631
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H -2.07463
GFUS GDP-L-fucose synthase -2.07377
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.06702
PTBP3 polypyrimidine tract binding protein 3 -2.06686
PANK3 pantothenate kinase 3 -2.06107
LIN7C lin-7 homolog C (C. elegans) -2.0514
PI15 peptidase inhibitor 15 -2.04895
MAT1A methionine adenosyltransferase I, alpha -2.0483
GET1 guided entry of tail-anchored proteins factor 1 -2.04805
RUNDC3B RUN domain containing 3B -2.04747
ARF4 ADP-ribosylation factor 4 -2.04685
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.04653
OMD osteomodulin -2.04364
CELF2 CUGBP, Elav-like family member 2 -2.03949
GTF2H5 general transcription factor IIH, polypeptide 5 -2.03912
TOP2A topoisomerase (DNA) II alpha 170kDa -2.03822
SGPP1 sphingosine-1-phosphate phosphatase 1 -2.03613
APOE apolipoprotein E -2.03334
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 -2.03283
NOAZFP nucleolar atypical zinc finger -2.02866
RLIG1 RNA 5'-phosphate and 3'-OH ligase 1 -2.02521
LEPROT leptin receptor overlapping transcript -2.02487
VASH2 vasohibin 2 -2.02282
PRPF38B pre-mRNA processing factor 38B -2.01744
LZTFL1 leucine zipper transcription factor-like 1 -2.01616
RAB30 RAB30, member RAS oncogene family -2.01418
SPAG4 sperm associated antigen 4 -2.01395
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -2.01157
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) -2.01143
RAB8A RAB8A, member RAS oncogene family -2.01111
ANG angiogenin, ribonuclease, RNase A family, 5 -2.01109
MRPL48 mitochondrial ribosomal protein L48 -2.00772
MXRA8 matrix-remodelling associated 8 -2.00426
TBC1D16 TBC1 domain family, member 16 -2.00346