CRCGN013_HEPG2_24H:K14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMBA 19.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

171 genes differentially expressed following the CRCGN013_HEPG2_24H:K14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 6.52519
ABHD4 abhydrolase domain containing 4 6.48681
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.38611
CNPY3 canopy FGF signaling regulator 3 5.72447
INPP1 inositol polyphosphate-1-phosphatase 5.45834
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 5.3465
GATA3 GATA binding protein 3 5.14325
TXNRD1 thioredoxin reductase 1 4.89531
TUBB6 tubulin, beta 6 class V 4.77851
CYCS cytochrome c, somatic 4.70749
DDB2 damage-specific DNA binding protein 2, 48kDa 4.58621
MICALL1 MICAL-like 1 4.53123
BLCAP bladder cancer associated protein 4.34478
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.2738
KIFBP kinesin family binding protein 4.222
SQSTM1 sequestosome 1 4.00093
FOSL1 FOS-like antigen 1 3.95274
LRP10 low density lipoprotein receptor-related protein 10 3.91905
KEAP1 kelch-like ECH-associated protein 1 3.80666
UBQLN2 ubiquilin 2 3.79013
GPC1 glypican 1 3.7573
BACE2 beta-site APP-cleaving enzyme 2 3.65783
CCL2 chemokine (C-C motif) ligand 2 3.65482
RPP38 ribonuclease P/MRP 38kDa subunit 3.65041
VAT1 vesicle amine transport 1 3.48032
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.26683
EPHB2 EPH receptor B2 3.18288
MAP7D1 MAP7 domain containing 1 3.14707
CCDC85B coiled-coil domain containing 85B 3.1166
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.09453
CTSL cathepsin L 3.09297
SQOR sulfide quinone oxidoreductase 3.06724
KLHL21 kelch-like family member 21 3.05383
SSBP2 single-stranded DNA binding protein 2 2.93176
HSPA1A heat shock 70kDa protein 1A 2.92498
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.83755
IER3 immediate early response 3 2.83488
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.79052
MAST2 microtubule associated serine/threonine kinase 2 2.72694
DUSP14 dual specificity phosphatase 14 2.6819
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.66194
CIAO3 cytosolic iron-sulfur assembly component 3 2.66182
XPC xeroderma pigmentosum, complementation group C 2.65146
ZFP36 ZFP36 ring finger protein 2.63162
ATP11B ATPase, class VI, type 11B 2.58089
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.47755
PLK3 polo-like kinase 3 2.46894
CASC3 cancer susceptibility candidate 3 2.39314
DDIT4 DNA-damage-inducible transcript 4 2.38005
CCDC86 coiled-coil domain containing 86 2.36911
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.35668
TIAM1 T-cell lymphoma invasion and metastasis 1 2.33271
PHLDA3 pleckstrin homology-like domain, family A, member 3 2.31708
IL4R interleukin 4 receptor 2.31511
GARS1 glycyl-tRNA synthetase 1 2.30439
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.27955
IP6K2 inositol hexakisphosphate kinase 2 2.26082
GATA2 GATA binding protein 2 2.25726
PEX11A peroxisomal biogenesis factor 11 alpha 2.24454
LSR lipolysis stimulated lipoprotein receptor 2.23095
RNF220 ring finger protein 220 2.22177
MISP mitotic spindle positioning 2.21497
RPRD2 regulation of nuclear pre-mRNA domain containing 2 2.21381
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 2.2077
AEN apoptosis enhancing nuclease 2.20411
DIPK1A divergent protein kinase domain 1A 2.19285
ATG9A autophagy related 9A 2.1796
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.17857
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) 2.16057
PRR15L proline rich 15-like 2.15483
NPDC1 neural proliferation, differentiation and control, 1 2.12701
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.12378
ADGRG1 adhesion G protein-coupled receptor G1 2.10336
PRKCQ protein kinase C, theta 2.09867
TP53I3 tumor protein p53 inducible protein 3 2.07841
PCDHB11 protocadherin beta 11 2.07384
FBXO2 F-box protein 2 2.07287
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.06065
GPX7 glutathione peroxidase 7 2.05825
ZNF423 zinc finger protein 423 2.04959
HLA-DRA major histocompatibility complex, class II, DR alpha 2.01299
CXCR4 chemokine (C-X-C motif) receptor 4 2.00262

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -7.96101
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -6.53645
ADI1 acireductone dioxygenase 1 -6.15978
CCNB2 cyclin B2 -5.82329
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.47167
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.95461
FGFR4 fibroblast growth factor receptor 4 -3.72725
RFC2 replication factor C (activator 1) 2, 40kDa -3.70077
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.51158
PSRC1 proline/serine-rich coiled-coil 1 -3.4952
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.48006
PTPRK protein tyrosine phosphatase, receptor type, K -3.46753
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.43143
ISOC1 isochorismatase domain containing 1 -3.41429
EXT1 exostosin glycosyltransferase 1 -3.37834
MSRA methionine sulfoxide reductase A -3.3092
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.26133
ANO10 anoctamin 10 -3.26083
ICAM3 intercellular adhesion molecule 3 -3.05026
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.02177
YME1L1 YME1-like 1 ATPase -3.00743
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 -2.94491
ENOPH1 enolase-phosphatase 1 -2.94469
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.91116
HMG20B high mobility group 20B -2.90297
ALDOC aldolase C, fructose-bisphosphate -2.87392
NR1H4 nuclear receptor subfamily 1, group H, member 4 -2.86154
ITGB1BP1 integrin beta 1 binding protein 1 -2.81497
USP6NL USP6 N-terminal like -2.7731
C5 complement component 5 -2.7731
MNAT1 MNAT CDK-activating kinase assembly factor 1 -2.6627
PGM1 phosphoglucomutase 1 -2.64148
SPAG4 sperm associated antigen 4 -2.60968
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.58456
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.57418
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.55036
PLK1 polo-like kinase 1 -2.53579
DERA deoxyribose-phosphate aldolase (putative) -2.53559
PCNA proliferating cell nuclear antigen -2.51503
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.4747
KLHDC2 kelch domain containing 2 -2.45799
PLS1 plastin 1 -2.44996
RHOBTB1 Rho-related BTB domain containing 1 -2.44659
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.43816
GNAS GNAS complex locus -2.43139
RSU1 Ras suppressor protein 1 -2.42154
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -2.40873
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.40389
SOAT2 sterol O-acyltransferase 2 -2.38429
CNKSR2 connector enhancer of kinase suppressor of Ras 2 -2.37213
EGF epidermal growth factor -2.36744
ETFA electron-transfer-flavoprotein, alpha polypeptide -2.36474
HMGA2 high mobility group AT-hook 2 -2.36226
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.35
CCKBR cholecystokinin B receptor -2.33763
MOCS2 molybdenum cofactor synthesis 2 -2.30077
INHA inhibin, alpha -2.27651
ZNF586 zinc finger protein 586 -2.2533
PROS1 protein S (alpha) -2.25037
PDIA6 protein disulfide isomerase family A, member 6 -2.21329
AURKB aurora kinase B -2.18933
OR7C1 olfactory receptor, family 7, subfamily C, member 1 -2.18478
VTI1B vesicle transport through interaction with t-SNAREs 1B -2.1815
ZMIZ1 zinc finger, MIZ-type containing 1 -2.16857
THEM6 thioesterase superfamily member 6 -2.16249
MAP2K1 mitogen-activated protein kinase kinase 1 -2.16169
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -2.16005
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.15974
ITGA1 integrin, alpha 1 -2.15903
PUM2 pumilio RNA-binding family member 2 -2.15757
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.14906
DENND2D DENN/MADD domain containing 2D -2.14356
PHF24 PHD finger protein 24 -2.1414
CABP1 calcium binding protein 1 -2.13819
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.11825
NPTX1 neuronal pentraxin I -2.10975
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -2.10776
GLRX5 glutaredoxin 5 -2.08709
OXR1 oxidation resistance 1 -2.08077
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) -2.0785
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.07814
ATF6 activating transcription factor 6 -2.04673
ZNF274 zinc finger protein 274 -2.03075
SMIM10L1 small integral membrane protein 10 like 1 -2.03026
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -2.02929
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.02234
ECH1 enoyl CoA hydratase 1, peroxisomal -2.02087
HEATR1 HEAT repeat containing 1 -2.0187