CRCGN013_HEPG2_24H:K16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMBA 4.95 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

57 genes differentially expressed following the CRCGN013_HEPG2_24H:K16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 9.29667
LCN2 lipocalin 2 5.10088
C2CD2 C2 calcium-dependent domain containing 2 4.58216
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.02583
NOSIP nitric oxide synthase interacting protein 3.8967
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.62048
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.4631
CARMIL1 capping protein regulator and myosin 1 linker 1 3.46143
PNKP polynucleotide kinase 3'-phosphatase 3.40187
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.38502
SNAP25 synaptosomal-associated protein, 25kDa 3.35109
TUBB6 tubulin, beta 6 class V 2.88701
ABHD4 abhydrolase domain containing 4 2.81751
DDB2 damage-specific DNA binding protein 2, 48kDa 2.75944
SFTPB surfactant protein B 2.73861
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.73298
KAT6A K(lysine) acetyltransferase 6A 2.66409
TXNRD1 thioredoxin reductase 1 2.61719
CBR3 carbonyl reductase 3 2.49682
CCL2 chemokine (C-C motif) ligand 2 2.36663
DIPK1A divergent protein kinase domain 1A 2.30631
ALOX15 arachidonate 15-lipoxygenase 2.25236
EGF epidermal growth factor 2.21627
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.18289
FOSL1 FOS-like antigen 1 2.16848
MLF1 myeloid leukemia factor 1 2.15865
CTDNEP1 CTD nuclear envelope phosphatase 1 2.14795
RALY RALY heterogeneous nuclear ribonucleoprotein 2.1439
CTSL cathepsin L 2.11978
CCP110 centriolar coiled coil protein 110kDa 2.11843
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.08478
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.06646
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.03039
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.01426

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.19483
ZW10 zw10 kinetochore protein -4.96858
TRIB3 tribbles pseudokinase 3 -4.09139
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.98634
ZDHHC6 zinc finger, DHHC-type containing 6 -3.85249
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.61647
DNM1L dynamin 1-like -3.44778
ZNF586 zinc finger protein 586 -3.406
MRPS16 mitochondrial ribosomal protein S16 -3.30218
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.22616
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.9567
TCTN1 tectonic family member 1 -2.86342
NGRN neugrin, neurite outgrowth associated -2.77831
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.76946
LDHD lactate dehydrogenase D -2.73461
TLCD3A TLC domain containing 3A -2.61233
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.58475
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.51564
MAPK13 mitogen-activated protein kinase 13 -2.30301
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.2367
HAT1 histone acetyltransferase 1 -2.23385
FGFR4 fibroblast growth factor receptor 4 -2.19659
MNAT1 MNAT CDK-activating kinase assembly factor 1 -2.14274