CRCGN013_HEPG2_24H:K18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMBA 1.24 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

53 genes differentially expressed following the CRCGN013_HEPG2_24H:K18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CARMIL1 capping protein regulator and myosin 1 linker 1 5.89172
TIAM1 T-cell lymphoma invasion and metastasis 1 4.68019
CDPF1 cysteine-rich, DPF motif domain containing 1 4.46699
SQOR sulfide quinone oxidoreductase 4.21861
MAP7 microtubule-associated protein 7 4.15236
PRR15L proline rich 15-like 3.98384
PPARG peroxisome proliferator-activated receptor gamma 3.87963
GPATCH8 G patch domain containing 8 3.78062
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.5513
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.53036
DYNLT3 dynein, light chain, Tctex-type 3 3.51534
GPER1 G protein-coupled estrogen receptor 1 3.49252
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.39178
CCL2 chemokine (C-C motif) ligand 2 3.23407
TREM1 triggering receptor expressed on myeloid cells 1 3.18685
KIFBP kinesin family binding protein 3.13787
ZFP36 ZFP36 ring finger protein 3.12416
STAP2 signal transducing adaptor family member 2 3.11218
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.90318
NOSIP nitric oxide synthase interacting protein 2.75958
LCN2 lipocalin 2 2.70796
CNPY3 canopy FGF signaling regulator 3 2.46855
ADAT1 adenosine deaminase, tRNA-specific 1 2.37184
ATP11B ATPase, class VI, type 11B 2.30302
ABHD4 abhydrolase domain containing 4 2.25082
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.19768
DDB2 damage-specific DNA binding protein 2, 48kDa 2.19324
MCF2L MCF.2 cell line derived transforming sequence-like 2.18433
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.13442
LRP10 low density lipoprotein receptor-related protein 10 2.12236
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.04221

decreased expression

Symbol Name Standardized Value
ARID5B AT rich interactive domain 5B (MRF1-like) -3.66329
MRPS2 mitochondrial ribosomal protein S2 -3.51677
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.3632
CD320 CD320 molecule -3.29761
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.27738
CRELD2 cysteine-rich with EGF-like domains 2 -3.25231
PCNA proliferating cell nuclear antigen -3.0149
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.9928
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.71337
CTSD cathepsin D -2.69763
RPS5 ribosomal protein S5 -2.64404
RFC2 replication factor C (activator 1) 2, 40kDa -2.64383
KDM3A lysine (K)-specific demethylase 3A -2.42237
LOC124907782 dual specificity protein phosphatase 22 -2.36561
HMG20B high mobility group 20B -2.34697
PDZD2 PDZ domain containing 2 -2.31823
MAPK13 mitogen-activated protein kinase 13 -2.26001
WDR7 WD repeat domain 7 -2.22454
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.15952
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.07514
EGF epidermal growth factor -2.06398
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 -2.05879