CRCGN013_HEPG2_24H:K22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenobarbital, sodium 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

29 genes differentially expressed following the CRCGN013_HEPG2_24H:K22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 5.10573
LCN2 lipocalin 2 4.6559
SSBP2 single-stranded DNA binding protein 2 3.15485
DIPK1A divergent protein kinase domain 1A 2.956
STIMATE STIM activating enhancer 2.56907
SQOR sulfide quinone oxidoreductase 2.32747
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.32418
CHN1 chimerin 1 2.30692
CCL2 chemokine (C-C motif) ligand 2 2.2172

decreased expression

Symbol Name Standardized Value
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -7.98548
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.94029
GNAS GNAS complex locus -5.25509
ZNF586 zinc finger protein 586 -4.39472
OXA1L oxidase (cytochrome c) assembly 1-like -4.14769
CCNB2 cyclin B2 -4.01188
RAB11FIP2 RAB11 family interacting protein 2 (class I) -3.96247
GDF15 growth differentiation factor 15 -3.49755
UGDH UDP-glucose 6-dehydrogenase -2.95397
DNM1L dynamin 1-like -2.93091
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.81265
GOLT1B golgi transport 1B -2.80436
TLCD3A TLC domain containing 3A -2.68199
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.36727
ITGB1BP1 integrin beta 1 binding protein 1 -2.30643
WASHC4 WASH complex subunit 4 -2.17369
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.0282
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -2.01175
NRIP1 nuclear receptor interacting protein 1 -2.00813
PGAM2 phosphoglycerate mutase 2 (muscle) -2.00073