CRCGN013_HEPG2_24H:L03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description p-nitroaniline 9.95 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

304 genes differentially expressed following the CRCGN013_HEPG2_24H:L03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 10.0
EPHB2 EPH receptor B2 9.87459
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 6.5741
HLA-DMA major histocompatibility complex, class II, DM alpha 6.3042
TATDN2 TatD DNase domain containing 2 5.35145
SNAP25 synaptosomal-associated protein, 25kDa 4.99047
MOK MOK protein kinase 4.9267
MSRA methionine sulfoxide reductase A 4.6946
GATA3 GATA binding protein 3 4.65922
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.573
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.54045
MYLK myosin light chain kinase 4.4141
SLC22A14 solute carrier family 22, member 14 3.8832
HOXA10 homeobox A10 3.85625
CYCS cytochrome c, somatic 3.85075
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.62738
FCHO1 FCH domain only 1 3.62685
STXBP2 syntaxin binding protein 2 3.5794
HLA-DRA major histocompatibility complex, class II, DR alpha 3.4675
GSTZ1 glutathione S-transferase zeta 1 3.44445
TBP TATA box binding protein 3.29455
JADE2 jade family PHD finger 2 3.2392
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 3.1503
CLDN11 claudin 11 3.09295
GCGR glucagon receptor 3.0786
HOXA7 homeobox A7 3.03705
GRIP2 glutamate receptor interacting protein 2 3.01025
IL13 interleukin 13 2.98965
IGFLR1 IGF-like family receptor 1 2.86725
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.86215
SCRN1 secernin 1 2.8477
PDLIM1 PDZ and LIM domain 1 2.835
F7 coagulation factor VII (serum prothrombin conversion accelerator) 2.83015
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.8207
RAD54L2 RAD54-like 2 (S. cerevisiae) 2.81275
BCL9 B-cell CLL/lymphoma 9 2.81155
PRR3 proline rich 3 2.805
TECR trans-2,3-enoyl-CoA reductase 2.7423
LPO lactoperoxidase 2.73285
CPNE7 copine VII 2.6806
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 2.6537
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 2.638
PICK1 protein interacting with PRKCA 1 2.6379
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene) 2.6374
ACO1 aconitase 1, soluble 2.63535
SH3BP1 SH3-domain binding protein 1 2.63015
MAP6D1 MAP6 domain containing 1 2.57855
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C 2.5713
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 2.55685
IQGAP1 IQ motif containing GTPase activating protein 1 2.55143
ZNF142 zinc finger protein 142 2.5512
SLC12A9 solute carrier family 12, member 9 2.5446
SLC75A1 solute carrier family 75 member 1 2.5299
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 2.52675
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 2.5172
GDF2 growth differentiation factor 2 2.51225
CD3E CD3e molecule, epsilon (CD3-TCR complex) 2.50155
CDX1 caudal type homeobox 1 2.4983
PCBP4 poly(rC) binding protein 4 2.49165
TPSG1 tryptase gamma 1 2.48545
CCL2 chemokine (C-C motif) ligand 2 2.46635
ANKZF1 ankyrin repeat and zinc finger domain containing 1 2.45555
DENND1C DENN/MADD domain containing 1C 2.45085
CLCNKA chloride channel, voltage-sensitive Ka 2.44745
LHX5 LIM homeobox 5 2.4443
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.4377
CNTN2 contactin 2 (axonal) 2.42815
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 2.4278
PMPCA peptidase (mitochondrial processing) alpha 2.42405
PCSK7 proprotein convertase subtilisin/kexin type 7 2.41945
CDHR1 cadherin-related family member 1 2.41355
ALG12 ALG12, alpha-1,6-mannosyltransferase 2.40325
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 2.3898
CLK4 CDC-like kinase 4 2.3861
SYT2 synaptotagmin II 2.37755
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 2.37575
MRPS22 mitochondrial ribosomal protein S22 2.3696
CD40LG CD40 ligand 2.36945
AMPD3 adenosine monophosphate deaminase 3 2.35722
PKD2L1 polycystic kidney disease 2-like 1 2.3522
PGLYRP4 peptidoglycan recognition protein 4 2.35035
ZNF384 zinc finger protein 384 2.34865
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma 2.33095
KRTAP5-2 keratin associated protein 5-2 2.3276
FBXO31 F-box protein 31 2.3186
ZSCAN9 zinc finger and SCAN domain containing 9 2.31845
BATF basic leucine zipper transcription factor, ATF-like 2.3107
AQP6 aquaporin 6, kidney specific 2.30928
RECQL4 RecQ protein-like 4 2.30485
UQCRB ubiquinol-cytochrome c reductase binding protein 2.29308
SFMBT1 Scm-like with four mbt domains 1 2.28895
COL11A2 collagen, type XI, alpha 2 2.28872
FMNL1 formin-like 1 2.28735
GDF5 growth differentiation factor 5 2.2777
GGCT gamma-glutamylcyclotransferase 2.27685
ECD ecdysoneless homolog (Drosophila) 2.27455
EVL Enah/Vasp-like 2.2731
DPF3 D4, zinc and double PHD fingers, family 3 2.2729
RHBG Rh family, B glycoprotein (gene/pseudogene) 2.26995
ABHD10 abhydrolase domain containing 10 2.269
PRB4 proline-rich protein BstNI subfamily 4 2.26655
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 2.2622
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 2.2549
MVB12B multivesicular body subunit 12B 2.25255
ESRRG estrogen-related receptor gamma 2.2443
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.2423
UBOX5 U-box domain containing 5 2.23927
SYNGR1 synaptogyrin 1 2.23845
INO80D INO80 complex subunit D 2.2353
MAP3K14 mitogen-activated protein kinase kinase kinase 14 2.22975
CIC capicua transcriptional repressor 2.2242
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2.22195
RBM7 RNA binding motif protein 7 2.2201
EPHB3 EPH receptor B3 2.21532
FOXH1 forkhead box H1 2.2148
FZD2 frizzled class receptor 2 2.2146
FES FES proto-oncogene, tyrosine kinase 2.21225
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) 2.21035
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene) 2.20775
NELFA negative elongation factor complex member A 2.20697
IGF2 insulin-like growth factor 2 2.19353
RCE1 Ras converting CAAX endopeptidase 1 2.1916
CDH15 cadherin 15, type 1, M-cadherin (myotubule) 2.18855
SFRP5 secreted frizzled-related protein 5 2.1856
COL6A2 collagen, type VI, alpha 2 2.18512
PPP1R16B protein phosphatase 1, regulatory subunit 16B 2.18403
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 2.18295
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 2.18087
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2 2.18002
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 2.1772
CEND1 cell cycle exit and neuronal differentiation 1 2.16975
INPP5J inositol polyphosphate-5-phosphatase J 2.1662
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.166
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2.1642
MYOD1 myogenic differentiation 1 2.15805
FXYD1 FXYD domain containing ion transport regulator 1 2.15745
DRP2 dystrophin related protein 2 2.1563
ARSF arylsulfatase F 2.1523
PRPF39 pre-mRNA processing factor 39 2.14945
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.13932
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.13885
KCNK7 potassium channel, two pore domain subfamily K, member 7 2.13045
CRH corticotropin releasing hormone 2.12803
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 2.12575
COL18A1 collagen, type XVIII, alpha 1 2.1238
TSPOAP1 TSPO associated protein 1 2.12375
CCNF cyclin F 2.12368
GMPPA GDP-mannose pyrophosphorylase A 2.11435
CRYGC crystallin, gamma C 2.1065
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2.1063
UNC93B1 unc-93 homolog B1 (C. elegans) 2.10085
ADAP1 ArfGAP with dual PH domains 1 2.09943
PLAGL1 pleiomorphic adenoma gene-like 1 2.09753
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 2.09608
NTF3 neurotrophin 3 2.09595
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 2.08855
EFNA3 ephrin-A3 2.0883
MED4 mediator complex subunit 4 2.08705
AIRE autoimmune regulator 2.085
ALG3 ALG3, alpha-1,3- mannosyltransferase 2.08405
GRHPR glyoxylate reductase/hydroxypyruvate reductase 2.08297
TDP1 tyrosyl-DNA phosphodiesterase 1 2.0808
CD5L CD5 molecule-like 2.07945
AQP5 aquaporin 5 2.0781
ZNF692 zinc finger protein 692 2.07795
TUBA8 tubulin, alpha 8 2.07505
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 2.0641
MATN1 matrilin 1, cartilage matrix protein 2.06113
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 2.0544
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 2.05135
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 2.0513
HSF4 heat shock transcription factor 4 2.0447
PRB2 proline-rich protein BstNI subfamily 2 2.04327
EGF epidermal growth factor 2.0402
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 2.0386
ZNF76 zinc finger protein 76 2.03575
RDH8 retinol dehydrogenase 8 (all-trans) 2.03555
GAK cyclin G associated kinase 2.0353
MMP17 matrix metallopeptidase 17 (membrane-inserted) 2.034
CLINT1 clathrin interactor 1 2.0334
KLRB1 killer cell lectin-like receptor subfamily B, member 1 2.03215
CD53 CD53 molecule 2.03135
CNTFR ciliary neurotrophic factor receptor 2.03085
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 2.02805
TRH thyrotropin-releasing hormone 2.0183
LRP3 low density lipoprotein receptor-related protein 3 2.0154
GPR27 G protein-coupled receptor 27 2.01445
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 2.01175
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 2.0105
CAPN1 calpain 1, (mu/I) large subunit 2.0097
IL16 interleukin 16 2.00957
OLFM4 olfactomedin 4 2.006
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7 2.0044
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 2.00253
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 2.0014
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 2.0012

decreased expression

Symbol Name Standardized Value
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -10.0
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -8.14715
CRK v-crk avian sarcoma virus CT10 oncogene homolog -6.7888
NGRN neugrin, neurite outgrowth associated -6.5707
CCNB1 cyclin B1 -5.81145
VAT1 vesicle amine transport 1 -5.43255
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -4.84845
DNM1L dynamin 1-like -4.7994
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -4.74632
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.7106
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.69415
ITGB1BP1 integrin beta 1 binding protein 1 -4.45075
CDC20 cell division cycle 20 -4.3391
KDM3A lysine (K)-specific demethylase 3A -4.27735
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.2371
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.861
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase -3.6779
TLR4 toll-like receptor 4 -3.5367
FASTKD5 FAST kinase domains 5 -3.4854
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 -3.36815
PTPRK protein tyrosine phosphatase, receptor type, K -3.3397
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -3.20173
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type -3.12745
CHIC2 cysteine-rich hydrophobic domain 2 -3.12585
ERC2 ELKS/RAB6-interacting/CAST family member 2 -3.03351
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -3.01955
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 -2.9693
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein -2.90585
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 -2.90185
TLCD3A TLC domain containing 3A -2.89755
UBE3C ubiquitin protein ligase E3C -2.88005
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.85907
CTNND1 catenin (cadherin-associated protein), delta 1 -2.85048
SNX11 sorting nexin 11 -2.81227
BFAR bifunctional apoptosis regulator -2.75815
VANGL1 VANGL planar cell polarity protein 1 -2.75045
RBMS1 RNA binding motif, single stranded interacting protein 1 -2.73554
SASH1 SAM and SH3 domain containing 1 -2.71375
RRAGC Ras-related GTP binding C -2.70975
TXNDC9 thioredoxin domain containing 9 -2.65795
WDR13 WD repeat domain 13 -2.58045
ZNF140 zinc finger protein 140 -2.5519
NLGN4X neuroligin 4, X-linked -2.53805
PHACTR1 phosphatase and actin regulator 1 -2.5326
EFL1 elongation factor like GTPase 1 -2.52345
MSH6 mutS homolog 6 -2.5209
KLF11 Kruppel-like factor 11 -2.4756
KIAA0319L KIAA0319-like -2.4615
RPA4 replication protein A4, 30kDa -2.4464
CXCL2 chemokine (C-X-C motif) ligand 2 -2.43625
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) -2.42775
ZNF257 zinc finger protein 257 -2.40995
MNT MAX network transcriptional repressor -2.4052
NR1H3 nuclear receptor subfamily 1, group H, member 3 -2.38785
GLOD4 glyoxalase domain containing 4 -2.3854
PRKCZ protein kinase C, zeta -2.36945
ENTREP1 endosomal transmembrane epsin interactor 1 -2.36905
RYR2 ryanodine receptor 2 (cardiac) -2.35633
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 -2.34955
RAD17 RAD17 homolog (S. pombe) -2.33483
CALCRL calcitonin receptor-like -2.3239
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 -2.32385
TM7SF3 transmembrane 7 superfamily member 3 -2.3133
SOWAHC sosondowah ankyrin repeat domain family member C -2.31195
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 -2.30335
MSH2 mutS homolog 2 -2.30315
MARK1 MAP/microtubule affinity-regulating kinase 1 -2.2984
DGKI diacylglycerol kinase, iota -2.29725
FFAR2 free fatty acid receptor 2 -2.29125
SKIC3 SKI3 subunit of superkiller complex -2.2782
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa -2.26455
GNS glucosamine (N-acetyl)-6-sulfatase -2.26172
PARN poly(A)-specific ribonuclease -2.23245
ANO3 anoctamin 3 -2.2317
HIKESHI heat shock protein nuclear import factor hikeshi -2.2245
MAGT1 magnesium transporter 1 -2.22025
SREK1IP1 SREK1-interacting protein 1 -2.21925
ACOX1 acyl-CoA oxidase 1, palmitoyl -2.21885
TRIM23 tripartite motif containing 23 -2.21597
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -2.20485
MRPL58 mitochondrial ribosomal protein L58 -2.20005
PELI1 pellino E3 ubiquitin protein ligase 1 -2.1943
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa -2.1836
KIF4A kinesin family member 4A -2.17645
SERF1A small EDRK-rich factor 1A (telomeric) -2.1608
TFCP2 transcription factor CP2 -2.14932
SOAT2 sterol O-acyltransferase 2 -2.14582
MRTFB myocardin related transcription factor B -2.1422
PCSK5 proprotein convertase subtilisin/kexin type 5 -2.14018
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.1292
OCLN occludin -2.1166
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 -2.1141
MAP2K5 mitogen-activated protein kinase kinase 5 -2.09133
ZFAND5 zinc finger, AN1-type domain 5 -2.09072
DAND5 DAN domain family member 5, BMP antagonist -2.08515
NR2C2 nuclear receptor subfamily 2, group C, member 2 -2.07595
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) -2.06672
NSG1 neuron specific gene family member 1 -2.06317
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) -2.0623
SPRR1B small proline-rich protein 1B -2.0609
PCYOX1 prenylcysteine oxidase 1 -2.0593
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 -2.0568
SLC38A2 solute carrier family 38, member 2 -2.0534
NME6 NME/NM23 nucleoside diphosphate kinase 6 -2.03925
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2 -2.03765
TXK TXK tyrosine kinase -2.0329
CYB5A cytochrome b5 type A (microsomal) -2.01933
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 -2.0064