| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 4-chloro-4'-aminodiphenylether 39.2 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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111 genes differentially expressed following the CRCGN013_HEPG2_24H:L07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GPER1 | G protein-coupled estrogen receptor 1 | 5.04716 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 4.61048 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | 3.99996 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 3.93732 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 3.82342 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 3.71874 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 3.65655 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.62053 |
| UBQLN2 | ubiquilin 2 | 3.61652 |
| ATP11B | ATPase, class VI, type 11B | 3.52218 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 3.41342 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 3.33204 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.28286 |
| UGDH | UDP-glucose 6-dehydrogenase | 3.17453 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 3.17055 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 3.13802 |
| ABHD4 | abhydrolase domain containing 4 | 3.11525 |
| NUCB2 | nucleobindin 2 | 3.09788 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 | 3.01343 |
| CBR1 | carbonyl reductase 1 | 2.94175 |
| PARP2 | poly (ADP-ribose) polymerase 2 | 2.91893 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 2.91634 |
| DDIT4 | DNA-damage-inducible transcript 4 | 2.90175 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 2.8996 |
| TRIB3 | tribbles pseudokinase 3 | 2.70952 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 2.65052 |
| KLHL9 | kelch-like family member 9 | 2.56646 |
| MTERF3 | mitochondrial transcription termination factor 3 | 2.48339 |
| SNX7 | sorting nexin 7 | 2.34414 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 2.33954 |
| PHGDH | phosphoglycerate dehydrogenase | 2.32504 |
| CYCS | cytochrome c, somatic | 2.30097 |
| DECR1 | 2,4-dienoyl CoA reductase 1, mitochondrial | 2.29762 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 2.27744 |
| SLC41A3 | solute carrier family 41, member 3 | 2.23158 |
| CEBPZ | CCAAT/enhancer binding protein (C/EBP), zeta | 2.19457 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | 2.18562 |
| GPATCH8 | G patch domain containing 8 | 2.16505 |
| EGF | epidermal growth factor | 2.14801 |
| SSBP2 | single-stranded DNA binding protein 2 | 2.13951 |
| PRR15L | proline rich 15-like | 2.112 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | 2.10226 |
| EIF2B3 | eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa | 2.10195 |
| SLC35B1 | solute carrier family 35, member B1 | 2.05824 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 2.05803 |
| TRIM2 | tripartite motif containing 2 | 2.05369 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 2.05167 |
| STAP2 | signal transducing adaptor family member 2 | 2.03337 |
| FOXO4 | forkhead box O4 | 2.03102 |
| ADAT1 | adenosine deaminase, tRNA-specific 1 | 2.0278 |
| MYBPC1 | myosin binding protein C, slow type | 2.01696 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 2.00894 |
| ATP6V0B | ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b | 2.0081 |
| PIGB | phosphatidylinositol glycan anchor biosynthesis, class B | 2.00696 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -8.49211 |
| GNAS | GNAS complex locus | -7.54104 |
| KDM3A | lysine (K)-specific demethylase 3A | -6.62732 |
| YME1L1 | YME1-like 1 ATPase | -4.99539 |
| ZNF586 | zinc finger protein 586 | -4.60132 |
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | -4.06022 |
| LAP3 | leucine aminopeptidase 3 | -3.71821 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -3.70743 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -3.68466 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -3.53927 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -3.46833 |
| PCNA | proliferating cell nuclear antigen | -3.46545 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -3.45908 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -3.33908 |
| CDC20 | cell division cycle 20 | -3.31196 |
| ZNF274 | zinc finger protein 274 | -3.24377 |
| FHL2 | four and a half LIM domains 2 | -3.23778 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -3.23509 |
| MELK | maternal embryonic leucine zipper kinase | -3.2044 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -3.15567 |
| IER3 | immediate early response 3 | -3.08155 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -3.04669 |
| TLCD3A | TLC domain containing 3A | -3.01732 |
| PLK1 | polo-like kinase 1 | -3.00687 |
| TCERG1 | transcription elongation regulator 1 | -2.99066 |
| SNX11 | sorting nexin 11 | -2.98378 |
| GOLT1B | golgi transport 1B | -2.95664 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -2.89986 |
| LBR | lamin B receptor | -2.88588 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -2.81067 |
| CCNB2 | cyclin B2 | -2.7679 |
| AURKB | aurora kinase B | -2.72129 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -2.70514 |
| PGAM4 | phosphoglycerate mutase family member 4 | -2.63626 |
| NLK | nemo-like kinase | -2.60106 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -2.44823 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -2.39226 |
| DUSP6 | dual specificity phosphatase 6 | -2.38927 |
| PDGFC | platelet derived growth factor C | -2.38069 |
| WASHC4 | WASH complex subunit 4 | -2.37916 |
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | -2.3696 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -2.31594 |
| CXADR | coxsackie virus and adenovirus receptor | -2.28192 |
| EGR1 | early growth response 1 | -2.27252 |
| CCNA2 | cyclin A2 | -2.23706 |
| GRB2 | growth factor receptor-bound protein 2 | -2.22735 |
| LIMD2 | LIM domain containing 2 | -2.22415 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -2.1996 |
| USP6NL | USP6 N-terminal like | -2.13555 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.08769 |
| CHMP4B | charged multivesicular body protein 4B | -2.087 |
| ALDOC | aldolase C, fructose-bisphosphate | -2.08267 |
| KIFC1 | kinesin family member C1 | -2.04891 |
| SNRPG | small nuclear ribonucleoprotein polypeptide G | -2.02922 |
| STMN1 | stathmin 1 | -2.02506 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | -2.0073 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | -2.00557 |
