CRCGN013_HEPG2_24H:L08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-chloro-4'-aminodiphenylether 19.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

74 genes differentially expressed following the CRCGN013_HEPG2_24H:L08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.87366
LCN2 lipocalin 2 6.41462
GPER1 G protein-coupled estrogen receptor 1 4.75888
LRP10 low density lipoprotein receptor-related protein 10 4.38567
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.28641
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.24047
MOK MOK protein kinase 4.0889
E2F2 E2F transcription factor 2 3.65546
ABHD4 abhydrolase domain containing 4 3.59511
HLA-DMA major histocompatibility complex, class II, DM alpha 3.49963
CHN1 chimerin 1 3.48511
ADRB2 adrenoceptor beta 2, surface 3.38449
EPHA3 EPH receptor A3 3.36229
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 3.06706
UBE2L6 ubiquitin-conjugating enzyme E2L 6 3.0161
TRIB3 tribbles pseudokinase 3 2.98139
GATA2 GATA binding protein 2 2.92679
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.92177
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.90658
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.89196
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.88858
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.78813
CDC45 cell division cycle 45 2.75486
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.74764
SSBP2 single-stranded DNA binding protein 2 2.70191
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.64406
H2BC12 H2B clustered histone 12 2.62071
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.5734
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.51828
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.39038
HLA-DRA major histocompatibility complex, class II, DR alpha 2.36017
SFTPB surfactant protein B 2.33342
PHGDH phosphoglycerate dehydrogenase 2.26638
RAB3D RAB3D, member RAS oncogene family 2.20478
EGF epidermal growth factor 2.18715
MINDY1 MINDY lysine 48 deubiquitinase 1 2.17692
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.14771
SCGB1D1 secretoglobin, family 1D, member 1 2.124
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.07337
RIC8A RIC8 guanine nucleotide exchange factor A 2.06198
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.04005

decreased expression

Symbol Name Standardized Value
TLCD3A TLC domain containing 3A -7.32047
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -7.12292
CDC20 cell division cycle 20 -4.7118
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.90537
ADI1 acireductone dioxygenase 1 -3.78353
DNM1L dynamin 1-like -3.66371
FASTKD5 FAST kinase domains 5 -3.45976
TNIP1 TNFAIP3 interacting protein 1 -3.44554
OXA1L oxidase (cytochrome c) assembly 1-like -3.39825
PCNA proliferating cell nuclear antigen -3.37582
ZNF274 zinc finger protein 274 -3.3228
TMEM109 transmembrane protein 109 -3.11147
RPS5 ribosomal protein S5 -2.79103
MELK maternal embryonic leucine zipper kinase -2.7349
CCP110 centriolar coiled coil protein 110kDa -2.67954
SMNDC1 survival motor neuron domain containing 1 -2.66842
CCNB2 cyclin B2 -2.61004
CDK1 cyclin-dependent kinase 1 -2.52104
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.50797
FGFR4 fibroblast growth factor receptor 4 -2.42838
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.40929
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha -2.39677
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.36449
FOSL1 FOS-like antigen 1 -2.35683
IER3 immediate early response 3 -2.26978
MAPK13 mitogen-activated protein kinase 13 -2.15748
GNAS GNAS complex locus -2.1348
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -2.12725
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.10721
CD320 CD320 molecule -2.10063
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.08266
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.06317
HMG20B high mobility group 20B -2.00008