CRCGN013_HEPG2_24H:L11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-chloro-4'-aminodiphenylether 2.45 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN013_HEPG2_24H:L11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHN1 chimerin 1 7.28286
MYLK myosin light chain kinase 4.98011
UBQLN2 ubiquilin 2 4.89233
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.62635
LCN2 lipocalin 2 4.5562
NPDC1 neural proliferation, differentiation and control, 1 3.87308
HOXA10 homeobox A10 3.8711
EAPP E2F-associated phosphoprotein 3.82457
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.61078
SNCA synuclein, alpha (non A4 component of amyloid precursor) 3.3124
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.85836
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.47567
MTERF3 mitochondrial transcription termination factor 3 2.47099
CYCS cytochrome c, somatic 2.4152
CYB561 cytochrome b561 2.39525
NOSIP nitric oxide synthase interacting protein 2.36576
GADD45A growth arrest and DNA-damage-inducible, alpha 2.28666
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.08627
FOS FBJ murine osteosarcoma viral oncogene homolog 2.04712
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.0127

decreased expression

Symbol Name Standardized Value
RPS4Y1 ribosomal protein S4, Y-linked 1 -5.0
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.93944
DSG2 desmoglein 2 -4.8123
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.60927
TLCD3A TLC domain containing 3A -4.54936
ZNF586 zinc finger protein 586 -4.48548
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.18011
CCNB2 cyclin B2 -3.79322
CDC20 cell division cycle 20 -3.73158
LDHD lactate dehydrogenase D -3.54897
PCNA proliferating cell nuclear antigen -3.49598
ZW10 zw10 kinetochore protein -3.20478
SLC35F2 solute carrier family 35, member F2 -3.05714
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.89987
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.65832
ICAM3 intercellular adhesion molecule 3 -2.5775
CCNB1 cyclin B1 -2.22484
LGALS4 lectin, galactoside-binding, soluble, 4 -2.09274
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.00563