CRCGN013_HEPG2_24H:L12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-chloro-4'-aminodiphenylether 1.23 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

47 genes differentially expressed following the CRCGN013_HEPG2_24H:L12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.07967
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.52683
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.37727
MAMLD1 mastermind-like domain containing 1 3.31617
DIPK1A divergent protein kinase domain 1A 3.25958
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 3.16651
NOTCH1 notch 1 3.15584
ADAT1 adenosine deaminase, tRNA-specific 1 2.94049
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.83623
ZNF589 zinc finger protein 589 2.75926
E2F2 E2F transcription factor 2 2.66031
BAMBI BMP and activin membrane-bound inhibitor 2.6454
EGF epidermal growth factor 2.63091
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.62402
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.53787
CSK c-src tyrosine kinase 2.51628
CCNH cyclin H 2.50386
CCDC85B coiled-coil domain containing 85B 2.50322
OXCT1 3-oxoacid CoA transferase 1 2.46658
MOK MOK protein kinase 2.39622
RRAGA Ras-related GTP binding A 2.3485
CCL2 chemokine (C-C motif) ligand 2 2.30005
ZFYVE26 zinc finger, FYVE domain containing 26 2.15017
LCN2 lipocalin 2 2.10672
DAAM1 dishevelled associated activator of morphogenesis 1 2.0939
FPGS folylpolyglutamate synthase 2.03393
SFTPB surfactant protein B 2.01763

decreased expression

Symbol Name Standardized Value
UBE3C ubiquitin protein ligase E3C -4.98921
ZNF586 zinc finger protein 586 -4.57607
CDC20 cell division cycle 20 -4.01958
CAB39 calcium binding protein 39 -4.01913
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.82806
ADI1 acireductone dioxygenase 1 -3.57367
SLC35F2 solute carrier family 35, member F2 -2.85187
TCTN1 tectonic family member 1 -2.83895
TLR4 toll-like receptor 4 -2.65272
COG2 component of oligomeric golgi complex 2 -2.54909
TEX10 testis expressed 10 -2.52366
IFRD2 interferon-related developmental regulator 2 -2.47943
TM9SF3 transmembrane 9 superfamily member 3 -2.46928
RGS2 regulator of G-protein signaling 2 -2.4686
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) -2.20887
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.1862
NGRN neugrin, neurite outgrowth associated -2.1564
RPS5 ribosomal protein S5 -2.15461
CCNB2 cyclin B2 -2.11314
STXBP2 syntaxin binding protein 2 -2.04564