CRCGN013_HEPG2_24H:L13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description emodin 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

501 genes differentially expressed following the CRCGN013_HEPG2_24H:L13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 7.68274
LCN2 lipocalin 2 7.475
ABHD4 abhydrolase domain containing 4 6.91457
FCHO1 FCH domain only 1 6.55862
STK10 serine/threonine kinase 10 6.02704
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 5.95032
CXCL2 chemokine (C-X-C motif) ligand 2 5.88516
ADRB2 adrenoceptor beta 2, surface 5.55923
LOXL1 lysyl oxidase-like 1 5.44466
TIAM1 T-cell lymphoma invasion and metastasis 1 5.42839
CCL2 chemokine (C-C motif) ligand 2 5.37374
RPL39L ribosomal protein L39-like 5.1708
MAMLD1 mastermind-like domain containing 1 5.10434
HMOX1 heme oxygenase 1 4.93243
LRP10 low density lipoprotein receptor-related protein 10 4.85429
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 4.42897
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.26287
KEAP1 kelch-like ECH-associated protein 1 4.23471
SSBP2 single-stranded DNA binding protein 2 4.21838
RAB21 RAB21, member RAS oncogene family 4.21562
IKZF1 IKAROS family zinc finger 1 (Ikaros) 4.20525
STAP2 signal transducing adaptor family member 2 4.18415
SQSTM1 sequestosome 1 4.17614
KIFBP kinesin family binding protein 4.14873
GRWD1 glutamate-rich WD repeat containing 1 4.14578
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.11548
CBR3 carbonyl reductase 3 4.09235
OXCT1 3-oxoacid CoA transferase 1 4.07602
OSMR oncostatin M receptor 3.99846
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.96371
C2CD2 C2 calcium-dependent domain containing 2 3.94341
CHMP6 charged multivesicular body protein 6 3.9387
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.76522
GRB10 growth factor receptor-bound protein 10 3.65102
C1QTNF3 C1q and tumor necrosis factor related protein 3 3.59395
TXNL4B thioredoxin-like 4B 3.58707
SYNE2 spectrin repeat containing, nuclear envelope 2 3.58185
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 3.56464
UGDH UDP-glucose 6-dehydrogenase 3.47983
ARL4C ADP-ribosylation factor-like 4C 3.45315
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.41617
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 3.40977
RAB4A RAB4A, member RAS oncogene family 3.39118
SIK3 SIK family kinase 3 3.38574
LOC122526780 uncharacterized LOC122526780 3.36949
SNAP25 synaptosomal-associated protein, 25kDa 3.35259
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 3.30347
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.29604
TRIB3 tribbles pseudokinase 3 3.29436
DYNLT3 dynein, light chain, Tctex-type 3 3.25437
RAP1GAP RAP1 GTPase activating protein 3.2523
E2F2 E2F transcription factor 2 3.24507
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 3.23356
ZNF354A zinc finger protein 354A 3.23141
KLRC1 killer cell lectin-like receptor subfamily C, member 1 3.22183
CGRRF1 cell growth regulator with ring finger domain 1 3.21445
HDGFL3 HDGF like 3 3.21311
DDIT4 DNA-damage-inducible transcript 4 3.18175
EPHA3 EPH receptor A3 3.1773
CSK c-src tyrosine kinase 3.17625
IL1B interleukin 1, beta 3.16017
DIPK1A divergent protein kinase domain 1A 3.13991
OSGIN1 oxidative stress induced growth inhibitor 1 3.11677
SCYL3 SCY1-like 3 (S. cerevisiae) 3.09439
RAB11FIP2 RAB11 family interacting protein 2 (class I) 3.07249
HEBP1 heme binding protein 1 3.06858
PEX11A peroxisomal biogenesis factor 11 alpha 3.04309
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 3.03083
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2 3.02585
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.01633
UBQLN2 ubiquilin 2 3.01551
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 2.99895
GSTZ1 glutathione S-transferase zeta 1 2.99862
BACE2 beta-site APP-cleaving enzyme 2 2.99783
LPAR2 lysophosphatidic acid receptor 2 2.98279
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.97249
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 2.92824
WWC3 WWC family member 3 2.91098
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.88088
KLRC3 killer cell lectin-like receptor subfamily C, member 3 2.88058
ZHX2 zinc fingers and homeoboxes 2 2.86444
NR0B1 nuclear receptor subfamily 0, group B, member 1 2.86249
ABHD6 abhydrolase domain containing 6 2.85472
RPP38 ribonuclease P/MRP 38kDa subunit 2.85204
TARS1 threonyl-tRNA synthetase 1 2.85121
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.8464
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 2.83129
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.82466
CBR1 carbonyl reductase 1 2.82332
COL11A1 collagen, type XI, alpha 1 2.81567
SPON1 spondin 1, extracellular matrix protein 2.79725
PLAAT4 phospholipase A and acyltransferase 4 2.78909
ARHGAP25 Rho GTPase activating protein 25 2.78054
DNM1 dynamin 1 2.77886
KLHL21 kelch-like family member 21 2.771
PSD3 pleckstrin and Sec7 domain containing 3 2.76718
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2.76051
CXCR4 chemokine (C-X-C motif) receptor 4 2.75079
APOA4 apolipoprotein A-IV 2.75022
CHN1 chimerin 1 2.74692
ACVR1 activin A receptor, type I 2.74616
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 2.74156
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.74155
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.71963
CAVIN3 caveolae associated protein 3 2.70967
TWSG1 twisted gastrulation BMP signaling modulator 1 2.69457
GHR growth hormone receptor 2.69415
TBPL1 TBP-like 1 2.69075
PRKCH protein kinase C, eta 2.68023
EPHB2 EPH receptor B2 2.6799
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 2.67485
RRAGA Ras-related GTP binding A 2.6698
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 2.65183
STAT4 signal transducer and activator of transcription 4 2.64584
ANO10 anoctamin 10 2.63141
NAP1L2 nucleosome assembly protein 1-like 2 2.61895
CAPN1 calpain 1, (mu/I) large subunit 2.60215
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.60184
REG1A regenerating islet-derived 1 alpha 2.60101
RAB31 RAB31, member RAS oncogene family 2.58613
ZFC3H1 zinc finger, C3H1-type containing 2.58463
COLGALT1 collagen beta(1-O)galactosyltransferase 1 2.58324
LPCAT3 lysophosphatidylcholine acyltransferase 3 2.576
UST uronyl-2-sulfotransferase 2.5617
RPGRIP1L RPGRIP1-like 2.55906
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 2.55238
TRIL TLR4 interactor with leucine-rich repeats 2.55138
PRND prion protein 2 (dublet) 2.54963
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 2.54785
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2.54051
PKN1 protein kinase N1 2.54039
DDR1 discoidin domain receptor tyrosine kinase 1 2.54031
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.53187
SLITRK2 SLIT and NTRK-like family, member 2 2.52951
SCN1A sodium channel, voltage gated, type I alpha subunit 2.52584
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 2.52572
MMP1 matrix metallopeptidase 1 2.52094
FKBP14 FK506 binding protein 14, 22 kDa 2.51722
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.51195
NLGN1 neuroligin 1 2.51019
STK32B serine/threonine kinase 32B 2.50063
DDA1 DET1 and DDB1 associated 1 2.47117
CAMTA2 calmodulin binding transcription activator 2 2.4693
BCR breakpoint cluster region 2.46883
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 2.46343
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.46224
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.45887
CCDC85B coiled-coil domain containing 85B 2.45416
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.4397
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.43215
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.42298
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.41637
CDC37L1 cell division cycle 37-like 1 2.41574
METTL18 methyltransferase like 18 2.40676
GPR45 G protein-coupled receptor 45 2.40651
CEMIP2 cell migration inducing hyaluronidase 2 2.40611
EFNA4 ephrin-A4 2.40538
DUSP6 dual specificity phosphatase 6 2.39126
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.39045
MTERF3 mitochondrial transcription termination factor 3 2.38558
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 2.38125
DNAL4 dynein, axonemal, light chain 4 2.3792
SYCP1 synaptonemal complex protein 1 2.37566
DPY19L1 dpy-19-like 1 (C. elegans) 2.37358
AADAC arylacetamide deacetylase 2.37111
CD40LG CD40 ligand 2.36416
GLI2 GLI family zinc finger 2 2.34721
SNX19 sorting nexin 19 2.34212
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.32828
JAK1 Janus kinase 1 2.32365
MEPCE methylphosphate capping enzyme 2.32356
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.32128
MN1 meningioma (disrupted in balanced translocation) 1 2.31822
SLC25A46 solute carrier family 25, member 46 2.31716
CDH22 cadherin 22, type 2 2.31281
BAD BCL2-associated agonist of cell death 2.30998
OPCML opioid binding protein/cell adhesion molecule-like 2.30996
PHF20L1 PHD finger protein 20-like 1 2.30648
LPIN2 lipin 2 2.30553
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 2.3022
PTPRE protein tyrosine phosphatase, receptor type, E 2.29698
NPTXR neuronal pentraxin receptor 2.29083
SPTA1 spectrin, alpha, erythrocytic 1 2.28593
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.2841
PAX2 paired box 2 2.27064
ELF4 E74-like factor 4 (ets domain transcription factor) 2.26876
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 2.26842
GCC1 GRIP and coiled-coil domain containing 1 2.25231
RNF25 ring finger protein 25 2.2509
EFS embryonal Fyn-associated substrate 2.24819
TNR tenascin R 2.24807
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.24331
LRRK1 leucine-rich repeat kinase 1 2.24046
PTPRK protein tyrosine phosphatase, receptor type, K 2.23945
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 2.23876
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.23875
CCNA1 cyclin A1 2.23837
HSPA13 heat shock protein 70kDa family, member 13 2.23493
CDCP1 CUB domain containing protein 1 2.23315
BRWD1 bromodomain and WD repeat domain containing 1 2.23062
CEP57 centrosomal protein 57kDa 2.22636
ULK1 unc-51 like autophagy activating kinase 1 2.21943
DMTN dematin actin binding protein 2.21616
FXYD5 FXYD domain containing ion transport regulator 5 2.21217
VPREB1 pre-B lymphocyte 1 2.21078
C1QL1 complement component 1, q subcomponent-like 1 2.21067
PTGES prostaglandin E synthase 2.20999
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 2.20879
TMEM100 transmembrane protein 100 2.20241
CBX6 chromobox homolog 6 2.20204
UNC13A unc-13 homolog A (C. elegans) 2.20184
SORCS3 sortilin-related VPS10 domain containing receptor 3 2.19864
PARP11 poly (ADP-ribose) polymerase family, member 11 2.19668
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 2.19201
IFNW1 interferon, omega 1 2.19116
GPR17 G protein-coupled receptor 17 2.1904
GYPE glycophorin E (MNS blood group) 2.18764
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2.1829
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 2.181
S1PR4 sphingosine-1-phosphate receptor 4 2.17832
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.17404
NTM neurotrimin 2.1679
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 2.16294
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.16139
MEP1B meprin A, beta 2.16097
GARS1 glycyl-tRNA synthetase 1 2.16074
PTN pleiotrophin 2.15937
XPO7 exportin 7 2.15839
EVI2A ecotropic viral integration site 2A 2.15737
CHODL chondrolectin 2.15665
THBS4 thrombospondin 4 2.15542
DOCK10 dedicator of cytokinesis 10 2.15212
PTPRM protein tyrosine phosphatase, receptor type, M 2.14771
TMEM19 transmembrane protein 19 2.13814
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.13723
ADAM12 ADAM metallopeptidase domain 12 2.13611
PEX2 peroxisomal biogenesis factor 2 2.13578
LIMD1 LIM domains containing 1 2.13443
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.13229
EAPP E2F-associated phosphoprotein 2.13179
PIM2 Pim-2 proto-oncogene, serine/threonine kinase 2.13101
PHKG2 phosphorylase kinase, gamma 2 (testis) 2.12806
SNAP91 synaptosomal-associated protein, 91kDa 2.12759
STXBP1 syntaxin binding protein 1 2.12646
BPGM 2,3-bisphosphoglycerate mutase 2.12619
PTPRG protein tyrosine phosphatase, receptor type, G 2.12353
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.1228
PCDHB16 protocadherin beta 16 2.12175
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.12156
JADE2 jade family PHD finger 2 2.11831
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 2.1176
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.11686
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 2.10868
VLDLR very low density lipoprotein receptor 2.10598
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 2.10207
WNT7B wingless-type MMTV integration site family, member 7B 2.10143
ETV1 ets variant 1 2.10028
BAALC brain and acute leukemia, cytoplasmic 2.09825
WNT2B wingless-type MMTV integration site family, member 2B 2.09459
UBE4A ubiquitination factor E4A 2.09361
MACIR macrophage immunometabolism regulator 2.09118
MAGEL2 melanoma antigen family L2 2.08964
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.08416
COL16A1 collagen, type XVI, alpha 1 2.08236
FRRS1L ferric-chelate reductase 1-like 2.07103
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 2.07095
CDPF1 cysteine-rich, DPF motif domain containing 1 2.07058
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 2.06903
THY1 Thy-1 cell surface antigen 2.06654
MUC1 mucin 1, cell surface associated 2.06604
FAM110B family with sequence similarity 110, member B 2.066
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.06559
MPDU1 mannose-P-dolichol utilization defect 1 2.06247
TLR3 toll-like receptor 3 2.06024
TASL TLR adaptor interacting with endolysosomal SLC15A4 2.05798
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent 2.04926
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 2.04824
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.04421
STEEP1 STING1 ER exit protein 1 2.0406
REG3A regenerating islet-derived 3 alpha 2.03954
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 2.03591
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.03572
DNM3 dynamin 3 2.03509
OMG oligodendrocyte myelin glycoprotein 2.03406
ENPEP glutamyl aminopeptidase (aminopeptidase A) 2.02624
LDOC1 leucine zipper, down-regulated in cancer 1 2.02312
SLC16A4 solute carrier family 16, member 4 2.02187
FOXE1 forkhead box E1 2.02089
PEX12 peroxisomal biogenesis factor 12 2.02043
TNIK TRAF2 and NCK interacting kinase 2.01929
CYTL1 cytokine-like 1 2.0175
VWA5A von Willebrand factor A domain containing 5A 2.01733
LSAMP limbic system-associated membrane protein 2.01676
BTBD8 BTB (POZ) domain containing 8 2.01584
NOX5 NADPH oxidase, EF-hand calcium binding domain 5 2.01107
VAMP4 vesicle-associated membrane protein 4 2.00811
ZNF783 zinc finger family member 783 2.00571
PAX8 paired box 8 2.00264

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.45141
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.89578
CASP3 caspase 3, apoptosis-related cysteine peptidase -5.35017
RPS5 ribosomal protein S5 -5.16705
DNM1L dynamin 1-like -5.11606
LOC124907782 dual specificity protein phosphatase 22 -5.11532
MELK maternal embryonic leucine zipper kinase -5.04646
PSRC1 proline/serine-rich coiled-coil 1 -5.00006
CDC20 cell division cycle 20 -4.90322
CCNB1 cyclin B1 -4.80491
B4GAT1 beta-1,4-glucuronyltransferase 1 -4.56653
AURKB aurora kinase B -4.52198
CCNA2 cyclin A2 -4.3348
PCCB propionyl CoA carboxylase, beta polypeptide -4.32962
PGAM4 phosphoglycerate mutase family member 4 -4.26687
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.17172
NUP85 nucleoporin 85kDa -4.11928
NGRN neugrin, neurite outgrowth associated -3.99487
S100A4 S100 calcium binding protein A4 -3.83649
ARFIP2 ADP-ribosylation factor interacting protein 2 -3.73462
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.72155
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.70217
GTPBP8 GTP-binding protein 8 (putative) -3.69721
UBE2C ubiquitin-conjugating enzyme E2C -3.68813
ILK integrin-linked kinase -3.63768
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.62378
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.59116
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.53264
CAB39 calcium binding protein 39 -3.53198
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -3.49533
HSPB1 heat shock 27kDa protein 1 -3.47411
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -3.42974
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -3.4231
TBC1D10C TBC1 domain family, member 10C -3.42081
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.41486
ZC3H7A zinc finger CCCH-type containing 7A -3.39094
PCNA proliferating cell nuclear antigen -3.36629
C5 complement component 5 -3.26881
SESN1 sestrin 1 -3.25644
GSTM2 glutathione S-transferase mu 2 (muscle) -3.25619
TCTN1 tectonic family member 1 -3.2501
BPHL biphenyl hydrolase-like (serine hydrolase) -3.24131
CRELD2 cysteine-rich with EGF-like domains 2 -3.23546
NCK1 NCK adaptor protein 1 -3.23024
OXA1L oxidase (cytochrome c) assembly 1-like -3.2283
FRS2 fibroblast growth factor receptor substrate 2 -3.21639
MRPS7 mitochondrial ribosomal protein S7 -3.15393
ACBD3 acyl-CoA binding domain containing 3 -3.1478
NLRP2B NLR family pyrin domain containing 2B -3.14295
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -3.09998
WASF3 WAS protein family, member 3 -3.09971
MYOC myocilin, trabecular meshwork inducible glucocorticoid response -3.09936
HADH hydroxyacyl-CoA dehydrogenase -3.08165
ATRAID all-trans retinoic acid-induced differentiation factor -3.07444
UBE3C ubiquitin protein ligase E3C -3.04426
PGM1 phosphoglucomutase 1 -3.04157
COG4 component of oligomeric golgi complex 4 -3.01339
MDH1 malate dehydrogenase 1, NAD (soluble) -3.01296
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.99445
PLK1 polo-like kinase 1 -2.98851
CDK1 cyclin-dependent kinase 1 -2.97195
FAF1 Fas (TNFRSF6) associated factor 1 -2.93763
JMJD6 jumonji domain containing 6 -2.91127
NOL11 nucleolar protein 11 -2.87309
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.8721
GTF2A2 general transcription factor IIA, 2, 12kDa -2.8491
DEXI Dexi homolog (mouse) -2.84859
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.8368
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -2.81102
DPH2 DPH2 homolog (S. cerevisiae) -2.79124
DNAAF5 dynein, axonemal, assembly factor 5 -2.79106
ZNF586 zinc finger protein 586 -2.78245
XPO4 exportin 4 -2.7731
PCID2 PCI domain containing 2 -2.76757
TUBB6 tubulin, beta 6 class V -2.75356
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.75225
RENBP renin binding protein -2.74135
OLFML2A olfactomedin-like 2A -2.72401
SNX11 sorting nexin 11 -2.7224
ALDOC aldolase C, fructose-bisphosphate -2.71484
TMEM214 transmembrane protein 214 -2.71047
MRPL39 mitochondrial ribosomal protein L39 -2.69786
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.68566
TOP2A topoisomerase (DNA) II alpha 170kDa -2.68241
VAT1 vesicle amine transport 1 -2.66975
SOAT2 sterol O-acyltransferase 2 -2.6683
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.65607
TMEM94 transmembrane protein 94 -2.62677
PRR7 proline rich 7 (synaptic) -2.58871
TM9SF2 transmembrane 9 superfamily member 2 -2.58201
NT5DC2 5'-nucleotidase domain containing 2 -2.57796
UBE3B ubiquitin protein ligase E3B -2.57389
PDCD6IP programmed cell death 6 interacting protein -2.56992
KHDC4 KH domain containing 4, pre-mRNA splicing factor -2.56073
LAP3 leucine aminopeptidase 3 -2.54479
CCDC86 coiled-coil domain containing 86 -2.53528
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -2.53002
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.525
ELAVL1 ELAV like RNA binding protein 1 -2.48867
LRPPRC leucine-rich pentatricopeptide repeat containing -2.47754
SIX3 SIX homeobox 3 -2.4752
MRPL23 mitochondrial ribosomal protein L23 -2.472
RCC1L RCC1 like -2.46232
KDM1A lysine (K)-specific demethylase 1A -2.46169
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa -2.44878
USP1 ubiquitin specific peptidase 1 -2.44184
BLCAP bladder cancer associated protein -2.43195
EIF4H eukaryotic translation initiation factor 4H -2.43059
ABT1 activator of basal transcription 1 -2.41981
FSTL3 follistatin-like 3 (secreted glycoprotein) -2.40831
SUMO4 small ubiquitin-like modifier 4 -2.39514
NFU1 NFU1 iron-sulfur cluster scaffold -2.39214
THOC1 THO complex 1 -2.38582
MOK MOK protein kinase -2.38294
C2CD5 C2 calcium-dependent domain containing 5 -2.3793
BIRC5 baculoviral IAP repeat containing 5 -2.36625
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.3589
STAMBP STAM binding protein -2.34249
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -2.33931
CRTAP cartilage associated protein -2.33637
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.32418
EIF2D eukaryotic translation initiation factor 2D -2.30382
ATP5PD ATP synthase peripheral stalk subunit d -2.30193
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.29325
CDCA3 cell division cycle associated 3 -2.28747
RFC2 replication factor C (activator 1) 2, 40kDa -2.28744
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.28738
RPL23A ribosomal protein L23a -2.2799
ZNF324 zinc finger protein 324 -2.2791
CCND3 cyclin D3 -2.27721
AKAP8 A kinase (PRKA) anchor protein 8 -2.27024
ACVR2B activin A receptor, type IIB -2.26868
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.26427
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.24391
ANAPC1 anaphase promoting complex subunit 1 -2.23584
CMTR1 cap methyltransferase 1 -2.22947
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) -2.22445
CTSH cathepsin H -2.22096
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.21215
SMG8 SMG8 nonsense mediated mRNA decay factor -2.20896
PHB1 prohibitin 1 -2.20785
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.20175
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.19722
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -2.19161
DHRS7B dehydrogenase/reductase (SDR family) member 7B -2.18915
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.1849
MAP2K1 mitogen-activated protein kinase kinase 1 -2.18475
RPS18 ribosomal protein S18 -2.18039
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.17898
TRIM31 tripartite motif containing 31 -2.17155
TMEM147 transmembrane protein 147 -2.17097
GABARAPL2 GABA(A) receptor-associated protein-like 2 -2.17039
DENND2D DENN/MADD domain containing 2D -2.1653
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 -2.16262
GRPEL1 GrpE-like 1, mitochondrial (E. coli) -2.15969
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI -2.15791
TMEM176B transmembrane protein 176B -2.14635
TRIP10 thyroid hormone receptor interactor 10 -2.14563
DDB2 damage-specific DNA binding protein 2, 48kDa -2.14468
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.14061
ATP5MC1 ATP synthase membrane subunit c locus 1 -2.1389
ELOVL2 ELOVL fatty acid elongase 2 -2.13395
TMEM11 transmembrane protein 11 -2.13202
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.12727
RPLP1 ribosomal protein, large, P1 -2.12659
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -2.12516
SLC66A2 solute carrier family 66 member 2 -2.12139
MTMR4 myotubularin related protein 4 -2.10913
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene) -2.103
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 -2.10006
PTCD3 pentatricopeptide repeat domain 3 -2.09062
RPL41 ribosomal protein L41 -2.08972
TMEM50A transmembrane protein 50A -2.089
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.08553
RFC3 replication factor C (activator 1) 3, 38kDa -2.08259
MKS1 Meckel syndrome, type 1 -2.08129
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -2.07989
TTC27 tetratricopeptide repeat domain 27 -2.07516
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.0676
IER5 immediate early response 5 -2.06562
PMPCA peptidase (mitochondrial processing) alpha -2.06059
LYPLA1 lysophospholipase I -2.05486
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.05443
MSX1 msh homeobox 1 -2.05189
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa -2.05053
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1 -2.04704
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) -2.04062
VSIG4 V-set and immunoglobulin domain containing 4 -2.0394
MRPL9 mitochondrial ribosomal protein L9 -2.03922
TFF3 trefoil factor 3 (intestinal) -2.02936
PLS3 plastin 3 -2.02579
COMMD1 copper metabolism (Murr1) domain containing 1 -2.01896
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.01746
NUP107 nucleoporin 107kDa -2.0173
ITGB1BP1 integrin beta 1 binding protein 1 -2.01602
TUBB4B tubulin, beta 4B class IVb -2.01414
RPS15 ribosomal protein S15 -2.01199
SELENOW selenoprotein W -2.01105
NANS N-acetylneuraminic acid synthase -2.00939
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit -2.0068
SYNGR2 synaptogyrin 2 -2.00248
UBA2 ubiquitin-like modifier activating enzyme 2 -2.00204
TRAP1 TNF receptor-associated protein 1 -2.00099